BACE1

BACE1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FKN, 1M4H, 1PY1, 1SGZ, 1TQF, 1UJJ, 1UJK, 1W50, 1W51, 1XN2, 1XN3, 1XS7, 1YM2, 1YM4, 2B8L, 2B8V, 2F3E, 2F3F, 2FDP, 2G94, 2HIZ, 2HM1, 2IQG, 2IRZ, 2IS0, 2NTR, 2OAH, 2OF0, 2OHK, 2OHL, 2OHM, 2OHN, 2OHP, 2OHQ, 2OHR, 2OHS, 2OHT, 2OHU, 2P4J, 2P83, 2P8H, 2PH6, 2PH8, 2Q11, 2Q15, 2QK5, 2QMD, 2QMF, 2QMG, 2QP8, 2QU2, 2QU3, 2QZK, 2QZL, 2VA5, 2VA6, 2VA7, 2VIE, 2VIJ, 2VIY, 2VIZ, 2VJ6, 2VJ7, 2VJ9, 2VKM, 2VNM, 2VNN, 2WEZ, 2WF0, 2WF1, 2WF2, 2WF3, 2WF4, 2WJO, 2XFI, 2XFJ, 2XFK, 2ZDZ, 2ZE1, 2ZHR, 2ZHS, 2ZHT, 2ZHU, 2ZHV, 2ZJH, 2ZJI, 2ZJJ, 2ZJK, 2ZJL, 2ZJM, 2ZJN, 3BRA, 3BUF, 3BUG, 3BUH, 3CIB, 3CIC, 3CID, 3CKP, 3CKR, 3DM6, 3DUY, 3DV1, 3DV5, 3EXO, 3FKT, 3H0B, 3HVG, 3HW1, 3I25, 3IGB, 3IN3, 3IN4, 3IND, 3INE, 3INF, 3INH, 3IVH, 3IVI, 3IXJ, 3IXK, 3KYR, 3L38, 3L3A, 3LHG, 3LNK, 3MSJ, 3MSK, 3MSL, 3N4L, 3NSH, 3OOZ, 3QI1, 3R1G, 3RSV, 3RTM, 3RVI, 3S2O, 3S7L, 3S7M, 3TPJ, 3TPL, 3TPP, 3TPR, 3UDH, 3UDJ, 3UDK, 3UDM, 3UDN, 3UDP, 3UDQ, 3UDR, 3UDY, 3UFL, 3UQP, 3UQR, 3UQU, 3UQW, 3UQX, 3VEU, 3VF3, 3VG1, 3VV6, 3VV7, 3ZMG, 3ZOV, 4ACU, 4ACX, 4AZY, 4B00, 4B05, 4B0Q, 4B1C, 4B1D, 4B1E, 4B70, 4B72, 4B77, 4B78, 4BEK, 4BFD, 4D83, 4D85, 4D88, 4D89, 4D8C, 4DH6, 4DI2, 4DJU, 4DJV, 4DJW, 4DJX, 4DJY, 4DPF, 4DPI, 4DUS, 4DV9, 4DVF, 4EWO, 4EXG, 4FCO, 4FGX, 4FM7, 4FM8, 4FRI, 4FRJ, 4FRK, 4FRS, 4FS4, 4FSE, 4FSL, 4GMI, 4H1E, 4H3F, 4H3G, 4H3I, 4H3J, 4HA5, 4HZT, 4I0E, 4I0F, 4I0G, 4I0H, 4I0J, 4I0Z, 4I10, 4I11, 4I12, 4I1C, 4J0T, 4J0V, 4J0Y, 4J0Z, 4J17, 4J1C, 4J1E, 4J1F, 4J1H, 4J1I, 4J1K, 4JOO, 4JP9, 4JPC, 4JPE, 4K8S, 4K9H, 4KE0, 4KE1, 3K5C, 3K5D, 3K5F, 3K5G, 3KMX, 3KMY, 3KN0, 3L58, 3L59, 3L5B, 3L5C, 3L5D, 3L5E, 3L5F, 3LPI, 3LPJ, 3LPK, 3OHF, 3OHH, 3PI5, 3QBH, 3R2F, 3RSX, 3RTH, 3RTN, 3RU1, 3SKF, 3SKG, 3U6A, 4GID, 4LXA, 4LXK, 4LXM, 3WB4, 3WB5, 4I0D, 4I0I, 4IVS, 4IVT, 4J0P, 4L7G, 4L7H, 4L7J, 4LC7, 4N00, 4PZW, 4PZX, 4R5N, 4R8Y, 4R91, 4R92, 4R93, 4R95, 4RCD, 4RCE, 4RCF, 4RRN, 4RRO, 4RRS, 4WY1, 4WY6, 4X2L, 4X7I, 4XKX, 4XXS, 4YBI, 4TRW, 4TRZ, 4ZSM, 4ZSP, 4ZSQ, 4ZSR, 4TRY, 4ZPF, 4ZPG, 5CLM, 5F01, 5EZZ, 5DQC, 5F00, 5EZX, 5HE7, 5HD0, 5HDX, 5HDV, 5HE5, 5HE4, 5HDU, 5HDZ, 5I3X, 5I3W, 5I3V, 5IE1, 5I3Y, 5ENK
Dynodwyr
Cyfenwau	BACE1, ASP2, BACE, HSPC104, beta-secretase 1
Dynodwyr allanol	OMIM: 604252 HomoloGene: 8014 GeneCards: BACE1
EC number	3.4.23.46
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • endopeptidase activity • amyloid-beta binding • beta-aspartyl-peptidase activity • GO:0001948, GO:0016582 protein binding • enzyme binding • hydrolase activity • GO:0070122 peptidase activity • aspartic-type endopeptidase activity Cydrannau o'r gell • multivesicular body • late endosome • endoplasmic reticulum lumen • bilen • Cellbilen • cell surface • axon • Reticwlwm endoplasmig • Golgi-associated vesicle lumen • endosome membrane • cytoplasmic vesicle membrane • GO:0016023 cytoplasmic vesicle • integral component of plasma membrane • membrane raft • Golgi apparatus • integral component of membrane • endosome • trans-Golgi network • lysosome • early endosome • synaptic vesicle • dendrite • soma • recycling endosome • hippocampal mossy fiber to CA3 synapse • presynapse Prosesau biolegol • GO:0044257 protein catabolic process • proteolysis • amyloid-beta metabolic process • membrane protein ectodomain proteolysis • modulation of chemical synaptic transmission • response to radiation • response to lead ion • positive regulation of neuron apoptotic process • detection of mechanical stimulus involved in sensory perception of pain • prepulse inhibition • cellular response to copper ion • cellular response to manganese ion • cellular response to amyloid-beta • regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23621	n/a
Ensembl	ENSG00000186318	n/a
UniProt	P56817	n/a
RefSeq (mRNA)	NM_138973 NM_001207048 NM_001207049 NM_012104 NM_138971 NM_138972	n/a
RefSeq (protein)	NP_001193977 NP_001193978 NP_036236 NP_620427 NP_620428 NP_620429 NP_036236.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BACE1 yw BACE1 a elwir hefyd yn Beta-secretase 1 a Beta-site APP-cleaving enzyme 1, isoform CRA_d (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q23.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BACE1.

• ASP2
• BACE
• HSPC104

• "Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1. ". Neurobiol Aging. 2017. PMID 28946017.
• "Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization. ". J Biol Chem. 2017. PMID 28637867.
• "Serum Starvation Induces BACE1 Processing and Secretion. ". Curr Alzheimer Res. 2017. PMID 27784219.
• "Inhibitory activities of major anthraquinones and other constituents from Cassia obtusifolia against β-secretase and cholinesterases. ". J Ethnopharmacol. 2016. PMID 27321278.
• "BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides.". J Ethnopharmacol. 2016. PMID 27275774.