AKR1A1

AKR1A1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2ALR
Dynodwyr
Cyfenwau	AKR1A1, ALDR1, ALR, ARM, DD3, HEL-S-6, Aldo-keto reductase family 1, member A1, aldo-keto reductase family 1, member A1 (aldehyde reductase), aldo-keto reductase family 1 member A1
Dynodwyr allanol	OMIM: 103830 HomoloGene: 74565 GeneCards: AKR1A1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • alditol:NADP+ 1-oxidoreductase activity • electron transfer activity • oxidoreductase activity • alcohol dehydrogenase (NADP+) activity • GO:0001948, GO:0016582 protein binding • aldo-keto reductase (NADP) activity • L-glucuronate reductase activity • glucuronolactone reductase activity • NAD-retinol dehydrogenase activity • allyl-alcohol dehydrogenase activity Cydrannau o'r gell • cytosol • extracellular exosome • apical plasma membrane • extracellular space • synapse • cytoplasm • Cellbilen • bilen Prosesau biolegol • cellular aldehyde metabolic process • aldehyde catabolic process • D-glucuronate catabolic process • L-ascorbic acid biosynthetic process • glutathione derivative biosynthetic process • glucuronate catabolic process to xylulose 5-phosphate • glucose metabolic process • electron transport chain • cellular detoxification of aldehyde • daunorubicin metabolic process • doxorubicin metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10327	n/a
Ensembl	ENSG00000117448	n/a
UniProt	P14550	n/a
RefSeq (mRNA)	NM_001202413 NM_001202414 NM_006066 NM_153326	n/a
RefSeq (protein)	NP_001189342 NP_001189343 NP_006057 NP_697021	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AKR1A1 yw AKR1A1 a elwir hefyd yn Aldo-keto reductase family 1 member A1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p34.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AKR1A1.

• "Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications. ". Acta Crystallogr D Biol Crystallogr. 1994. PMID 15299353.
• "Characterization of the human aldehyde reductase gene and promoter. ". Genomics. 1999. PMID 10486210.
• "[Effect of AKR1A1 knock-down on H2;O2; and 4-hydroxynonenal-induced cytotoxicity in human 1321N1 astrocytoma cells]. ". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013. PMID 23643085.
• "The role of aldehyde reductase AKR1A1 in the metabolism of γ-hydroxybutyrate in 1321N1 human astrocytoma cells. ". Chem Biol Interact. 2011. PMID 21276435.
• "The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism.". Biochim Biophys Acta. 2005. PMID 15769597.