SMAP1

SMAP1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2CRR
Identifikatori
Aliasi	SMAP1
Vanjski ID-jevi	OMIM: 611372 MGI: 2138261 HomoloGene: 134676 GeneCards: SMAP1
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	70,862,011 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	23,961,398 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• clathrin binding; • vezivanje iona metala; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity;
Ćelijska komponenta	• citoplazma; • ćelijska membrana; • membrana;
Biološki proces	• GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • regulation of clathrin-dependent endocytosis; • positive regulation of erythrocyte differentiation;
	Izvori:Amigo / QuickGO
Ortolozi
	60682
	98366
	ENSG00000112305
	ENSMUSG00000026155
	Q8IYB5
	Q91VZ6
	NM_001044305; NM_001281439; NM_001281440; NM_021940
	NM_001290683; NM_028534; NM_001357395
	NP_001037770; NP_001268368; NP_001268369; NP_068759
	NP_001277612; NP_082810; NP_001344324
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Stromski membranski pridruženi protein 1 je protein koji je kod ljudi kodiran genom SMAP1.^[5]^[6]^[7]

Protein kodiran ovim genom sličan je mišjem proteinu 1 povezanom sa stromskom membranom. Ova sličnost sugerira da je ovaj ljudski genski proizvod također tip II membranski glikoprotein uključen u eritropoetsku stimulacijsku aktivnost stromnih ćelija. Alternativna prerada rezultira u više varijanti transkripta koje kodiraju različite izoforme.^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 467 aminokiselina, а molekulska težina 50.386 Da.^[8]

10	20	30	40	50
MATRSCREKA	QKLNEQHQLI	LSKLLREEDN	KYCADCEAKG	PRWASWNIGV
FICIRCAGIH	RNLGVHISRV	KSVNLDQWTA	EQIQCMQDMG	NTKARLLYEA
NLPENFRRPQ	TDQAVEFFIR	DKYEKKKYYD	KNAIAITNIS	SSDAPLQPLV
SSPSLQAAVD	KNKLEKEKEK	KKEEKKREKE	PEKPAKPLTA	EKLQKKDQQL
EPKKSTSPKK	AAEPTVDLLG	LDGPAVAPVT	NGNTTVPPLN	DDLDIFGPMI
SNPLPATVMP	PAQGTPSAPA	AATLSTVTSG	DLDLFTEQTT	KSEEVAKKQL
SKDSILSLYG	TGTIQQQSTP	GVFMGPTNIP	FTSQAPAAFQ	GFPSMGVPVP
AAPGLIGNVM	GQSPSMMVGM	PMPNGFMGNA	QTGVMPLPQN	VVGPQGGMVG
QMGAPQSKFG	LPQAQQPQWS	LSQMNQQMAG	MSISSATPTA	GFGQPSSTTA
GWSGSSSGQT	LSTQLWK

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112305 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026155 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sato Y, Hong HN, Yanai N, Obinata M (Sep 1998). "Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment". J Biochem. 124 (1): 209–16. doi:10.1093/oxfordjournals.jbchem.a022082. PMID 9644265.
^ Marcos I, Borrego S, Rodriguez de Cordoba S, Galan JJ, Antinolo G (Jul 2002). "Cloning, characterization and chromosome mapping of the human SMAP1 gene". Gene. 292 (1–2): 167–71. doi:10.1016/S0378-1119(02)00645-5. PMID 12119110.
^ ^a ^b "SMAP1 small ArfGAP 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Pristupljeno 7. 5. 2021.
^ "UniProt, Q8IYB5". Pristupljeno 27. 8. 2021.

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tanabe K, Torii T, Natsume W, et al. (2005). "A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis". Mol. Biol. Cell. 16 (4): 1617–28. doi:10.1091/mbc.E04-08-0683. PMC 1073646. PMID 15659652.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Barragan I, Marcos I, Borrego S, Antiñolo G (2006). "Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa". Int. J. Mol. Med. 16 (6): 1163–7. doi:10.3892/ijmm.16.6.1163. PMID 16273301.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112305 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026155 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9644265-5] Sato Y, Hong HN, Yanai N, Obinata M (Sep 1998). "Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment". J Biochem. 124 (1): 209–16. doi:10.1093/oxfordjournals.jbchem.a022082. PMID 9644265.

[pmid12119110-6] Marcos I, Borrego S, Rodriguez de Cordoba S, Galan JJ, Antinolo G (Jul 2002). "Cloning, characterization and chromosome mapping of the human SMAP1 gene". Gene. 292 (1–2): 167–71. doi:10.1016/S0378-1119(02)00645-5. PMID 12119110.

[:0-7] "SMAP1 small ArfGAP 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Pristupljeno 7. 5. 2021.

[UniProt-8] "UniProt, Q8IYB5". Pristupljeno 27. 8. 2021.

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