REXO4

REXO4
Identifikatori
Aliasi	REXO4
Vanjski ID-jevi	OMIM: 602930 MGI: 2684957 HomoloGene: 133948 GeneCards: REXO4
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	133,418,096 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	26,854,398 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • nuclease activity; • exonuclease activity; • hydrolase activity; • nucleic acid binding; • vezivanje sa RNK; • single-stranded DNA binding; • GO:0001105 transcription coactivator activity; • endonuclease activity; • 3'-5' exonuclease activity;
Ćelijska komponenta	• Jedarce; • jedro; • nuclear speck;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • nucleic acid phosphodiester bond hydrolysis; • DNA catabolic process, endonucleolytic; • DNA catabolic process, exonucleolytic; • rRNA processing; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	57109
	227656
	ENSG00000280706; ENSG00000148300
	ENSMUSG00000052406
	Q9GZR2
	Q6PAQ4
	NM_001279349; NM_001279350; NM_001279351; NM_020385
	NM_207234; NM_001362876
	NP_001266278; NP_001266279; NP_001266280; NP_065118
	NP_997117; NP_001349805
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

RNK-egzonukleaza 4 je enzim koji je kod ljudi kodiran genom REXO4.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 422 aminokiseline, а molekulska težina 46.672 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGKAKVPASK	RAPSSPVAKP	GPVKTLTRKK	NKKKKRFWKS	KAREVSKKPA
SGPGAVVRPP	KAPEDFSQNW	KALQEWLLKQ	KSQAPEKPLV	ISQMGSKKKP
KIIQQNKKET	SPQVKGEEMP	AGKDQEASRG	SVPSGSKMDR	RAPVPRTKAS
GTEHNKKGTK	ERTNGDIVPE	RGDIEHKKRK	AKEAAPAPPT	EEDIWFDDVD
PADIEAAIGP	EAAKIARKQL	GQSEGSVSLS	LVKEQAFGGL	TRALALDCEM
VGVGPKGEES	MAARVSIVNQ	YGKCVYDKYV	KPTEPVTDYR	TAVSGIRPEN
LKQGEELEVV	QKEVAEMLKG	RILVGHALHN	DLKVLFLDHP	KKKIRDTQKY
KPFKSQVKSG	RPSLRLLSEK	ILGLQVQQAE	HCSIQDAQAA	MRLYVMVKKE
WESMARDRRP	LLTAPDHCSD	DA

Reference

^ ^a ^b ^c ENSG00000148300 GRCh38: Ensembl release 89: ENSG00000280706, ENSG00000148300 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052406 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kwiatkowska J, Slomski R, Jozwiak S, Short MP, Kwiatkowski DJ (Nov 1997). "Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1". Genomics. 44 (3): 350–4. doi:10.1006/geno.1997.4874. PMID 9325058.
^ "Entrez Gene: REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)".
^ "UniProt, Q9GZR2". Pristupljeno 11. 9. 2021.

Dopunska literatura

Montano MM, Wittmann BM, Bianco NR (2000). "Identification and characterization of a novel factor that regulates quinone reductase gene transcriptional activity". J. Biol. Chem. 275 (44): 34306–13. doi:10.1074/jbc.M003880200. PMID 10908561.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

Vanjski linkovi

[refGRCh38Ensembl-1] ENSG00000148300 GRCh38: Ensembl release 89: ENSG00000280706, ENSG00000148300 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052406 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9325058-5] Kwiatkowska J, Slomski R, Jozwiak S, Short MP, Kwiatkowski DJ (Nov 1997). "Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1". Genomics. 44 (3): 350–4. doi:10.1006/geno.1997.4874. PMID 9325058.

[entrez-6] "Entrez Gene: REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)".

[UniProt-7] "UniProt, Q9GZR2". Pristupljeno 11. 9. 2021.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak