SLC9A4

SLC9A4
Identifikatori
Aliasi	SLC9A4
Vanjski ID-jevi	OMIM: 600531 MGI: 105074 HomoloGene: 72232 GeneCards: SLC9A4
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	102,533,972 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	40,669,885 bp
Ontologija gena
Molekularna funkcija	• solute:proton antiporter activity; • antiporter activity; • sodium:proton antiporter activity; • potassium:proton antiporter activity;
Ćelijska komponenta	• integral component of membrane; • basolateral plasma membrane; • apical plasma membrane; • membrana; • ćelijska membrana;
Biološki proces	• gastric acid secretion; • proton transmembrane transport; • epithelial cell development; • cation transport; • ion transport; • regulation of pH; • sodium ion transport; • regulation of intracellular pH; • sodium ion import across plasma membrane; • potassium ion transmembrane transport; • transmembrane transport; • anion transmembrane transport;
	Izvori:Amigo / QuickGO
Ortolozi
	389015
	110895
	ENSG00000180251
	ENSMUSG00000026065
	Q6AI14
	Q8BUE1
	NM_001011552
	NM_177084
	NP_001011552
	NP_796058
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Niskofinitetni natrij-glukozni kotransporter, znan i kao natrij/glukoza kotransporter 3 (SGLT3) ili član 4 poriodice 5 rastvornih nosača (SLC5A4) jest protein koji je kod ljudi kodiran genom SLC5A4 sa hromosoma 2.^[5]^[6]^[7] Funkcionira kao senzor šećera.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 659 aminokiselina, a molekulska težina 72.456 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MASTVSPSTI	AETPEPPPLS	DHIRNAADIS	VIVIYFLVVM	AVGLWAMLKT
NRGTIGGFFL	AGRDMAWWPM	GASLFASNIG	SNHYVGLAGT	GAASGVATVT
FEWTSSVMLL	ILGWIFVPIY	IKSGVMTMPE	YLKKRFGGER	LQVYLSILSL
FICVVLLISA	DIFAGAIFIK	LALGLDLYLA	IFILLAMTAV	YTTTGGLASV
IYTDTLQTII	MLIGSFILMG	FAFNEVGGYE	SFTEKYVNAT	PSVVEGDNLT
ISASCYTPRA	DSFHIFRDAV	TGDIPWPGII	FGMPITALWY	WCTNQVIVQR
CLCGKDMSHV	KAACIMCAYL	KLLPMFLMVM	PGMISRILYT	DMVACVVPSE
CVKHCGVDVG	CTNYAYPTMV	LELMPQGLRG	LMLSVMLASL	MSSLTSIFNS
ASTLFTIDLY	TKMRKQASEK	ELLIAGRIFV	LLLTVVSIVW	VPLVQVSQNG
QLIHYTESIS	SYLGPPIAAV	FVLAIFCKRV	NEQGAFWGLM	VGLAMGLIRM
ITEFAYGTGS	CLAPSNCPKI	ICGVHYLYFS	IVLFFGSMLV	TLGISLLTKP
IPDVHLYRLC	WVLRNSTEER	IDIDAEEKSQ	EETDDGVEED	YPEKSRGCLK
KAYDLFCGLQ	KGPKLTKEEE	EALSKKLTDT	SERPSWRTIV	NINAILLLAV
VVFIHGYYA

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180251 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026065 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)".
^ Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H (mart 1998). "Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1". Proceedings of the National Academy of Sciences of the United States of America. 95 (6): 2914–9. Bibcode:1998PNAS...95.2914V. doi:10.1073/pnas.95.6.2914. PMC 19669. PMID 9501190.
^ Jung H (oktobar 2002). "The sodium/substrate symporter family: structural and functional features". FEBS Letters. 529 (1): 73–7. doi:10.1016/S0014-5793(02)03184-8. PMID 12354616.
^ "UniProt, Q9NY91" (jezik: engleski). Pristupljeno 19. 11. 2021.

Dpunska literatura

Munafò MR, Clark TG, Roberts KH, Johnstone EC (2006). "Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression". Neuropsychobiology. 53 (1): 1–8. doi:10.1159/000089915. PMID 16319503. S2CID 12803994.
Blaya C, Salum GA, Lima MS, Leistner-Segal S, Manfro GG (2007). "Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis". Behavioral and Brain Functions. 3: 41. doi:10.1186/1744-9081-3-41. PMC 1994953. PMID 17705872.
Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H (septembar 2003). "A glucose sensor hiding in a family of transporters". Proceedings of the National Academy of Sciences of the United States of America. 100 (20): 11753–8. Bibcode:2003PNAS..10011753D. doi:10.1073/pnas.1733027100. PMC 208830. PMID 13130073.
Fairchild TJ (januar 2008). "Protection of muscle membrane excitability during cycling in humans: a role for SGLT3?". Journal of Applied Physiology. 104 (1): 315, author reply 316. doi:10.1152/japplphysiol.00793.2007. PMID 18198291.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (decembar 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM (februar 2007). "Imino sugars are potent agonists of the human glucose sensor SGLT3". Molecular Pharmacology. 71 (2): 628–34. doi:10.1124/mol.106.030288. PMID 17110502. S2CID 13642065.

Vnjski ninkovi

Šablon:Porodica rastvornih nosača

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000180251 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026065 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)".

[pmid9501190-6] Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H (mart 1998). "Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1". Proceedings of the National Academy of Sciences of the United States of America. 95 (6): 2914–9. Bibcode:1998PNAS...95.2914V. doi:10.1073/pnas.95.6.2914. PMC 19669. PMID 9501190.

[pmid12354616-7] Jung H (oktobar 2002). "The sodium/substrate symporter family: structural and functional features". FEBS Letters. 529 (1): 73–7. doi:10.1016/S0014-5793(02)03184-8. PMID 12354616.

[UniProt-8] "UniProt, Q9NY91" (jezik: engleski). Pristupljeno 19. 11. 2021.

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