BRIX1

BRIX1
Identifikatori
Aliasi	BRIX1
Vanjski ID-jevi	OMIM: 618466 MGI: 1915082 HomoloGene: 10133 GeneCards: BRIX1
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	34,925,996 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	10,486,033 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa RNK; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• Jedarce; • jedro;
Biološki proces	• ribosome biogenesis; • ribosomal large subunit assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	55299
	67832
	ENSG00000113460
	ENSMUSG00000022247
	Q8TDN6
	Q9DCA5
	NM_018321
	NM_026396
	NP_060791
	NP_080672
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

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Homolog proteina BRX1 ribosomske biogeneze (BRIX1), znan i kao briks protein 2 sa domenom (BXDC2) jest protein koji je kod ljudi kodiran genom BRIX1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 353 aminokiseline, а molekulska težina 41.401 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAATKRKRRG	GFAVQAKKPK	RNEIDAEPPA	KRHATAEEVE	EEERDRIPGP
VCKGKWKNKE	RILIFSSRGI	NFRTRHLMQD	LRMLMPHSKA	DTKMDRKDKL
FVINEVCEMK	NCNKCIYFEA	KKKQDLYMWL	SNSPHGPSAK	FLVQNIHTLA
ELKMTGNCLK	GSRPLLSFDP	AFDELPHYAL	LKELLIQIFS	TPRYHPKSQP
FVDHVFTFTI	LDNRIWFRNF	QIIEEDAALV	EIGPRFVLNL	IKIFQGSFGG
PTLYENPHYQ	SPNMHRRVIR	SITAAKYREK	QQVKDVQKLR	KKEPKTLLPH
DPTADVFVTP	AEEKPIEIQW	VKPEPKVDLK	ARKKRIYKRQ	RKMKQRMDSG
KTK

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113460 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022247 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ "Entrez Gene: BXDC2 brix domain containing 2".
^ "UniProt, Q8TDN6" (jezik: engleski). Pristupljeno 13. 10. 2021.

Dopunska literatura

Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Kaser A, Bogengruber E, Hallegger M, et al. (2002). "Brix from xenopus laevis and brx1p from yeast define a new family of proteins involved in the biogenesis of large ribosomal subunits". Biol. Chem. 382 (12): 1637–47. doi:10.1515/BC.2001.199. PMID 11843177. S2CID 23636837.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113460 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022247 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gene: BXDC2 brix domain containing 2".

[UniProt-7] "UniProt, Q8TDN6" (jezik: engleski). Pristupljeno 13. 10. 2021.

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