Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region (Q93162416)

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scientific article published on 06 September 2019

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English	Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region	scientific article published on 06 September 2019

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4 May 2020

Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region (English)

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4 May 2020

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4 May 2020

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Annalisa Verrico

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4 May 2020

Paola Rovella

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4 May 2020

Laura Di Francesco

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4 May 2020

Michela Damizia

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4 May 2020

David Sasah Staid

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4 May 2020

Loredana Le Pera

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4 May 2020

M Eugenia Schininà

7

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6 September 2019

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4 May 2020

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4 May 2020

2

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4 May 2020

454-468

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4 May 2020

The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.

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Inhibition of Karyopherin beta 1 suppresses prostate cancer growth

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Upregulation of nuclear transporter, Kpnβ1, contributes to accelerated cell proliferation- and cell adhesion-mediated drug resistance (CAM-DR) in diffuse large B-cell lymphoma

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Importin β1 mediates nuclear factor-κB signal transduction into the nuclei of myeloma cells and affects their proliferation and apoptosis

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Karyopherinβ1 regulates proliferation of human glioma cells via Wnt/β-catenin pathway

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Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity

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Importazole, a small molecule inhibitor of the transport receptor importin-β

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Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic.

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Nuclear import inhibitor N-(4-hydroxyphenyl) retinamide targets Zika virus (ZIKV) nonstructural protein 5 to inhibit ZIKV infection.

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Inhibition of Importin β1 With a 2-Aminothiazole Derivative Resulted in G2/M Cell-cycle Arrest and Apoptosis

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Quantitative structural analysis of importin-β flexibility: paradigm for solenoid protein structures

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Structural Biology and Regulation of Protein Import into the Nucleus

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Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking

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7 January 2021

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GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta

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7 January 2021

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Extensive cargo identification reveals distinct biological roles of the 12 importin pathways

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7 January 2021

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Identification of cargo proteins specific for importin-β with importin-α applying a stable isotope labeling by amino acids in cell culture (SILAC)-based in vitro transport system.

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Visualization of human karyopherin beta-1/importin beta-1 interactions with protein partners in mitotic cells by co-immunoprecipitation and proximity ligation assays

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7 January 2021

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Systems analysis of Ran transport

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Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation

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Nuclear transport factors: global regulation of mitosis

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Karyopherins in cancer

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The functional versatility of the nuclear pore complex proteins

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SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer

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The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes

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The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo

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Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores.

1 reference

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Importin-β and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function.

1 reference

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Regulated degradation of spindle assembly factors by the anaphase-promoting complex.

1 reference

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7 January 2021

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RanGTP aids anaphase entry through Ubr5-mediated protein turnover

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma

1 reference

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7 January 2021

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HURP Is a Ran-Importin β-Regulated Protein that Stabilizes Kinetochore Microtubules in the Vicinity of Chromosomes

1 reference

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7 January 2021

based on heuristic

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HURP is part of a Ran-dependent complex involved in spindle formation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Importin beta is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture.

1 reference

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7 January 2021

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Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells

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Mitotic Disassembly of Nuclear Pore Complexes Involves CDK1- and PLK1-Mediated Phosphorylation of Key Interconnecting Nucleoporins

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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1 reference

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based on heuristic

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

HURP wraps microtubule ends with an additional tubulin sheet that has a novel conformation of tubulin

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1038/S41388-019-0989-X

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4 May 2020

PubMed publication ID

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Europe PubMed Central

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4 May 2020

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