The R251K Substitution in Viral Protein PB2 Increases Viral Replication and Pathogenicity of Eurasian Avian-like H1N1 Swine Influenza Viruses (Q92447407)

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scientific article published on 02 January 2020

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English	The R251K Substitution in Viral Protein PB2 Increases Viral Replication and Pathogenicity of Eurasian Avian-like H1N1 Swine Influenza Viruses	scientific article published on 02 January 2020

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29 April 2020

The R251K Substitution in Viral Protein PB2 Increases Viral Replication and Pathogenicity of Eurasian Avian-like H1N1 Swine Influenza Viruses (English)

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29 April 2020

swine influenza

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Mengkai Cai

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29 April 2020

Ruting Zhong

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29 April 2020

Chenxiao Qin

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29 April 2020

Zhiqing Yu

4

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29 April 2020

Xiaoyan Wen

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29 April 2020

Junsi Xian

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29 April 2020

Yongjie Chen

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29 April 2020

Yu Cai

8

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29 April 2020

Heyou Yi

9

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29 April 2020

Lang Gong

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29 April 2020

Guihong Zhang

11

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29 April 2020

publication date

2 January 2020

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29 April 2020

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29 April 2020

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29 April 2020

1

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29 April 2020

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Creative Commons Attribution 4.0 International

2 January 2020

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Human infection with a novel reassortant Eurasian-avian lineage swine H1N1 virus in northern China

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11 February 2021

Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China

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11 February 2021

Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice

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11 February 2021

Emergence of Eurasian Avian-Like Swine Influenza A (H1N1) Virus from an Adult Case in Fujian Province, China

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11 February 2021

Substitution of D701N in the PB2 protein could enhance the viral replication and pathogenicity of Eurasian avian-like H1N1 swine influenza viruses.

1 reference

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11 February 2021

Adaptive evolution during the establishment of European avian-like H1N1 influenza A virus in swine.

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11 February 2021

Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009.

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11 February 2021

Molecular evolution of H1N1 swine influenza in Guangdong, China, 2016-2017.

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11 February 2021

Specific mutations in the PB2 protein of influenza A virus compensate for the lack of efficient IFN antagonism of the NS1 protein of bat influenza A-like viruses

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Influenza Pathogenesis in Genetically Defined Resistant and Susceptible Murine Strains

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11 February 2021

A Single-Amino-Acid Substitution at Position 225 in HA Alters the Transmissibility of Eurasian Avian-like H1N1 Swine Influenza Virus in Guinea Pigs

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11 February 2021

Swine influenza A (H1N1) virus (SIV) infection requiring extracorporeal life support in an immunocompetent adult patient with indirect exposure to pigs, Italy, October 2016.

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11 February 2021

Severe acute respiratory infection caused by swine influenza virus in a child necessitating extracorporeal membrane oxygenation (ECMO), the Netherlands, October 2016.

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11 February 2021

Reassortant Eurasian Avian-Like Influenza A(H1N1) Virus from a Severely Ill Child, Hunan Province, China, 2015

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11 February 2021

Live poultry market workers are susceptible to both avian and swine influenza viruses, Guangdong Province, China

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11 February 2021

The soft palate is an important site of adaptation for transmissible influenza viruses

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11 February 2021

Changes to the dynamic nature of hemagglutinin and the emergence of the 2009 pandemic H1N1 influenza virus

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11 February 2021

The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication

1 reference

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11 February 2021

A combination of HA and PA mutations enhances virulence in a mouse-adapted H6N6 influenza A virus.

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11 February 2021

Amino acid changes in the influenza A virus PA protein that attenuate avian H5N1 viruses in mammals

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11 February 2021

Expansion of genotypic diversity and establishment of 2009 H1N1 pandemic-origin internal genes in pigs in China.

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11 February 2021

Evolution and ecology of influenza A viruses.

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11 February 2021

Computational assay of H7N9 influenza neuraminidase reveals R292K mutation reduces drug binding affinity

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11 February 2021

Human infection with Eurasian avian-like influenza A(H1N1) virus, China

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11 February 2021

Asparagine substitution at PB2 residue 701 enhances the replication, pathogenicity, and transmission of the 2009 pandemic H1N1 influenza A virus

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11 February 2021

Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011.

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11 February 2021

Key molecular factors in hemagglutinin and PB2 contribute to efficient transmission of the 2009 H1N1 pandemic influenza virus

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11 February 2021

Amino acid residues 253 and 591 of the PB2 protein of avian influenza virus A H9N2 contribute to mammalian pathogenesis

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Long-term evolution and transmission dynamics of swine influenza A virus

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PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells

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11 February 2021

PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice

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Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

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The pig as a mixing vessel for influenza viruses: Human and veterinary implications.

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Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans

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11 February 2021

Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N.

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An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

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PB2 protein of a highly pathogenic avian influenza virus strain A/chicken/Yamaguchi/7/2004 (H5N1) determines its replication potential in pigs

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Cases of swine influenza in humans: a review of the literature

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Functional domains of the influenza A virus PB2 protein: identification of NP- and PB1-binding sites

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Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding

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Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses

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The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits

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A DNA transfection system for generation of influenza A virus from eight plasmids

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Two separate sequences of PB2 subunit constitute the RNA cap-binding site of influenza virus RNA polymerase

1 reference

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A pandemic warning?

1 reference

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Genetic relatedness of hemagglutinins of the H1 subtype of influenza A viruses isolated from swine and birds

1 reference

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11 February 2021

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10.3390/V12010052

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29 April 2020

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29 April 2020

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29 April 2020

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