Modulation of regulatory T cell function and stability by co-inhibitory receptors (Q91740193)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32269380%20AND%20SRC:MED&resulttype=core&format=json

24 April 2020

review article

1 reference

title

Modulation of regulatory T cell function and stability by co-inhibitory receptors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32269380%20AND%20SRC:MED&resulttype=core&format=json

24 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32269380%20AND%20SRC:MED&resulttype=core&format=json

Margarita Domínguez-Villar

24 April 2020

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32269380%20AND%20SRC:MED&resulttype=core&format=json

24 April 2020

publication date

8 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32269380%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Immunology

24 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32269380%20AND%20SRC:MED&resulttype=core&format=json

tTregs, pTregs, and iTregs: similarities and differences

24 April 2020

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7 January 2021

Impaired expansion of regulatory T cells in a neonatal thymectomy-induced autoimmune mouse model

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7 January 2021

Atherosclerosis-Driven Treg Plasticity Results in Formation of a Dysfunctional Subset of Plastic IFNγ+ Th1/Tregs.

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7 January 2021

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7 January 2021

Cancer immunotherapy with check point inhibitor can cause autoimmune adverse events due to loss of Treg homeostasis

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7 January 2021

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

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The T-cell receptor repertoire of tumor-infiltrating regulatory T lymphocytes is skewed toward public sequences

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7 January 2021

Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome.

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7 January 2021

CD4+CD25high T cells are enriched in the tumor and peripheral blood of prostate cancer patients

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7 January 2021

CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer

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7 January 2021

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

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7 January 2021

Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation

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7 January 2021

Understanding the Warburg effect: the metabolic requirements of cell proliferation

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7 January 2021

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth

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7 January 2021

Metabolic Barriers to T Cell Function in Tumors

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7 January 2021

Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction

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Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.

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7 January 2021

A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells

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7 January 2021

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

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7 January 2021

CTLA-4-mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells

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7 January 2021

Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

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7 January 2021

Requirement of Treg-intrinsic CTLA4/PKCη signaling pathway for suppressing tumor immunity

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7 January 2021

Protein kinase C-η controls CTLA-4-mediated regulatory T cell function

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7 January 2021

The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.

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7 January 2021

Novel Foxo1-dependent transcriptional programs control T(reg) cell function

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7 January 2021

Role of LAG-3 in regulatory T cells.

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7 January 2021

Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types

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7 January 2021

Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.

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7 January 2021

Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3

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7 January 2021

LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes.

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7 January 2021

Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells

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7 January 2021

An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos.

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7 January 2021

LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites

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7 January 2021

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7 January 2021

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

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7 January 2021

Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors

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7 January 2021

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

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7 January 2021

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.

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7 January 2021

Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model

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7 January 2021

PD-1 marks dysfunctional regulatory T cells in malignant gliomas

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7 January 2021

Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

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7 January 2021

Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity.

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7 January 2021

Treg Fragility: A Prerequisite for Effective Antitumor Immunity?

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7 January 2021

Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy

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7 January 2021

Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells.

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7 January 2021

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.

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7 January 2021

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

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7 January 2021

CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation.

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7 January 2021

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses

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7 January 2021

TIGIT signaling restores suppressor function of Th1 Tregs

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7 January 2021

The TIGIT/CD226 axis regulates human T cell function

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7 January 2021

TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease.

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7 January 2021

Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells

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7 January 2021

Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.

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7 January 2021

TIGIT predominantly regulates the immune response via regulatory T cells.

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7 January 2021

PD-1 regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

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7 January 2021

Identification of Endothelial Cell Junctional Proteins and Lymphocyte Receptors Involved in Transendothelial Migration of Human Effector Memory CD4+ T Cells

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7 January 2021

Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing.

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7 January 2021

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells.

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7 January 2021

Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy

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7 January 2021

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

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7 January 2021

Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4+Foxp3+ Regulatory T Cells

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7 January 2021

Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition

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7 January 2021

Neuropilin-1 expression identifies a subset of regulatory T cells in human lymph nodes that is modulated by preoperative chemoradiation therapy in cervical cancer

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7 January 2021

Neuropilin‐1 is not a marker of human Foxp3+ Treg

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7 January 2021

Metastatic tumour cells favour the generation of a tolerogenic milieu in tumour draining lymph node in patients with early cervical cancer.

1 reference

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7 January 2021

Novel expression of Neuropilin 1 on human tumor-infiltrating lymphocytes in colorectal cancer liver metastases

1 reference

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7 January 2021

Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1

1 reference

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7 January 2021

Altered expression of regulatory molecules in the skin of psoriasis

1 reference

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7 January 2021

Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth

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7 January 2021

Semaphorins in interactions between T cells and antigen-presenting cells

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7 January 2021

Neuropilin-1 attenuates autoreactivity in experimental autoimmune encephalomyelitis

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7 January 2021

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

1 reference

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7 January 2021

TIM3 comes of age as an inhibitory receptor

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

T Cell/Transmembrane, Ig, and Mucin-3 Allelic Variants Differentially Recognize Phosphatidylserine and Mediate Phagocytosis of Apoptotic Cells

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

TIM3(+)FOXP3(+) regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Co-expression of LAG3 and TIM3 identifies a potent Treg population that suppresses macrophage functions in colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Ovarian carcinoma-infiltrating regulatory T cells were more potent suppressors of CD8(+) T cell inflammation than their peripheral counterparts, a function dependent on TIM3 expression

1 reference

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7 January 2021

Tim3+ Foxp3 + Treg Cells Are Potent Inhibitors of Effector T Cells and Are Suppressed in Rheumatoid Arthritis.

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Downregulation of IL-10 secretion by Treg cells in osteoarthritis is associated with a reduction in Tim-3 expression

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity

1 reference

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7 January 2021

Chimeric Antigen Receptor (CAR) Treg: A Promising Approach to Inducing Immunological Tolerance

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7 January 2021

Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy

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7 January 2021

Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer

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7 January 2021

A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity

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7 January 2021

Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups

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7 January 2021

Immune checkpoint inhibitor myocarditis

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7 January 2021

Multiple sclerosis outcomes after cancer immunotherapy

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatment

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

CTLA4 as Immunological Checkpoint in the Development of Multiple Sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers-Response

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

CD226 opposes TIGIT to disrupt Tregs in melanoma

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Hyperprogressive disease: recognizing a novel pattern to improve patient management

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Decline of programmed death-1-positive circulating T regulatory cells predicts more favourable clinical outcome of patients with melanoma under immune checkpoint blockade

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4.

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Immune checkpoint inhibitors in cancer therapy: a focus on T-regulatory cells

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Granzyme B-expressing treg cells are enriched in colorectal cancer and present the potential to eliminate autologous T conventional cells

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areata

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Human regulatory T cells lack the cyclophosphamide-extruding transporter ABCB1 and are more susceptible to cyclophosphamide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Diphtheria toxin-based recombinant murine IL-2 fusion toxin for depleting murine regulatory T cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans.

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Effector Regulatory T Cells Reflect the Equilibrium between Antitumor Immunity and Autoimmunity in Adult T-cell Leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

The PI3K Pathway in Human Disease

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Turning off AKT: PHLPP as a drug target

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity.

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Treatment with rapamycin can restore regulatory T-cell function in IPEX patients

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

A function for interleukin 2 in Foxp3-expressing regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Interleukin 2 signaling is required for CD4(+) regulatory T cell function

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

An essential role for the IL-2 receptor in Treg cell function

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Revisiting IL-2: Biology and therapeutic prospects

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

1 reference

https://api.crossref.org/works/10.1038%2FS41577-020-0296-3

7 January 2021

10.1038/S41577-020-0296-3

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32269380%20AND%20SRC:MED&resulttype=core&format=json

24 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32269380%20AND%20SRC:MED&resulttype=core&format=json