The biological function of ELABELA and APJ signaling in the cardiovascular system and pre-eclampsia (Q90970887)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30626933%20AND%20SRC:MED&resulttype=core&format=json

18 April 2020

title

The biological function of ELABELA and APJ signaling in the cardiovascular system and pre-eclampsia (English)

1 reference

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18 April 2020

1 reference

Yuanyuan Liu

1 reference

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18 April 2020

Liquan Wang

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30626933%20AND%20SRC:MED&resulttype=core&format=json

18 April 2020

Hongjun Shi

series ordinal

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18 April 2020

publication date

9 January 2019

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18 April 2020

published in

Hypertension Research

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18 April 2020

volume

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18 April 2020

issue

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18 April 2020

page(s)

928-934

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30626933%20AND%20SRC:MED&resulttype=core&format=json

Pathogenesis of preeclampsia

18 April 2020

cites work

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7 January 2021

The biology of preeclampsia

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7 January 2021

Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1.

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7 January 2021

Immunology of pre-eclampsia

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7 January 2021

Pathophysiology and Current Clinical Management of Preeclampsia

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7 January 2021

A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

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7 January 2021

Apela Regulates Fluid Homeostasis by Binding to the APJ Receptor to Activate Gi Signaling

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7 January 2021

Apelin receptors: From signaling to antidiabetic strategy.

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7 January 2021

The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.

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7 January 2021

Apelin and energy metabolism.

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7 January 2021

ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice

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7 January 2021

Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway

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7 January 2021

Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor

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7 January 2021

Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin

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7 January 2021

Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity

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7 January 2021

Central and peripheral apelin receptor distribution in the mouse: species differences with rat

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7 January 2021

Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin

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7 January 2021

The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism

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7 January 2021

Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells

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7 January 2021

Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells

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7 January 2021

Apelin and its receptor APJ in cardiovascular diseases

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7 January 2021

Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system

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7 January 2021

Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure.

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7 January 2021

Modification of the terminal residue of apelin-13 antagonizes its hypotensive action

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7 January 2021

Effect of apelin on glomerular hemodynamic function in the rat kidney

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7 January 2021

Apelin activates L-arginine/nitric oxide synthase/nitric oxide pathway in rat aortas

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7 January 2021

Apelin is a positive regulator of ACE2 in failing hearts.

1 reference

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7 January 2021

Apelin-13 inhibits large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle cells via a PI3-kinase dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apelin-13 upregulates Egr-1 expression in rat vascular smooth muscle cells through the PI3K/Akt and PKC signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apj Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target

1 reference

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7 January 2021

Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility

1 reference

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7 January 2021

Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms

1 reference

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7 January 2021

The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo

1 reference

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7 January 2021

Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload

1 reference

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7 January 2021

Apelin protects sarcoplasmic reticulum function and cardiac performance in ischaemia-reperfusion by attenuating oxidation of sarcoplasmic reticulum Ca2+-ATPase and ryanodine receptor

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Endogenous regulation of cardiovascular function by apelin-APJ.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Toddler: an embryonic signal that promotes cell movement via Apelin receptors

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

ELABELA: a hormone essential for heart development signals via the apelin receptor

1 reference

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7 January 2021

Apela exhibits isoform- and headgroup-dependent modulation of micelle binding, peptide conformation and dynamics

1 reference

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7 January 2021

ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.

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7 January 2021

Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart.

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7 January 2021

Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension

1 reference

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7 January 2021

ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage.

1 reference

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7 January 2021

The Aplnr GPCR regulates myocardial progenitor development via a novel cell-non-autonomous, Gα(i/o) protein-independent pathway

1 reference

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7 January 2021

Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia

1 reference

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7 January 2021

Nitric oxide and carbon monoxide production and metabolism in preeclampsia.

1 reference

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7 January 2021

The role of nitric oxide in the pathogenesis of preeclampsia

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7 January 2021

Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild pre-eclampsia and threatened preterm labor

1 reference

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7 January 2021

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

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7 January 2021

Mechanism of hypoxia-induced GCM1 degradation: implications for the pathogenesis of preeclampsia

1 reference

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7 January 2021

Loss of Akt increases soluble endoglin release from endothelial cells but not placenta.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Potential biomarkers of preeclampsia: inverse correlation between hydrogen peroxide and nitric oxide early in maternal circulation and at term in placenta of women with preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

The plasma and placental levels of malondialdehyde, glutathione and superoxide dismutase in pre-eclampsia

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Oxidative stress and apoptosis in preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Oxidative Stress in Preeclampsia and Placental Diseases.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apelin attenuates oxidative stress in human adipocytes.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apelin protects heart against ischemia/reperfusion injury in rat.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

D5 dopamine receptor decreases NADPH oxidase, reactive oxygen species and blood pressure via heme oxygenase-1.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apelin suppresses apoptosis of human vascular smooth muscle cells via APJ/PI3-K/Akt signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apelin suppresses apoptosis of human osteoblasts

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

The effects of water immersion and restraint stress on the expressions of apelin, apelin receptor (APJR) and apoptosis rate in the rat heart

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apelin-13 protects the brain against ischemia/reperfusion injury through activating PI3K/Akt and ERK1/2 signaling pathways.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apelin-36, a potent peptide, protects against ischemic brain injury by activating the PI3K/Akt pathway.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Trophoblast Apoptosis in Placentas from Pregnancies Complicated by Preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Epithelial-mesenchymal transition during extravillous trophoblast differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

TGF-beta-induced epithelial to mesenchymal transition

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Inhibition of trophoblast cell invasion by TGFB1, 2, and 3 is associated with a decrease in active proteases

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Effects of tumour necrosis factor-alpha, interleukin-1 alpha, macrophage colony stimulating factor and transforming growth factor beta on trophoblastic matrix metalloproteinases

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Effect of transforming growth factor-beta on the plasminogen activator system in cultured first trimester human cytotrophoblasts

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Transforming growth factor-β1 inhibits trophoblast cell invasion by inducing Snail-mediated down-regulation of vascular endothelial-cadherin protein.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Dual effect of transforming growth factor beta1 on cell adhesion and invasion in human placenta trophoblast cells

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Expression of e-cadherin and beta-catenin in trophoblastic tissue in normal and pathological pregnancies

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apelin attenuates TGF-β1-induced epithelial to mesenchymal transition via activation of PKC-ε in human renal tubular epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

Apelin protects against acute renal injury by inhibiting TGF-β1.

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

ELABELA/APELA Levels Are Not Decreased in the Maternal Circulation or Placenta among Women with Preeclampsia

1 reference

https://api.crossref.org/works/10.1038%2FS41440-018-0193-3

7 January 2021

10.1038/S41440-018-0193-3

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30626933%20AND%20SRC:MED&resulttype=core&format=json

18 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30626933%20AND%20SRC:MED&resulttype=core&format=json