Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling (Q90349354)

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13 April 2020

title

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling (English)

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13 April 2020

Panagis Filippakopoulos

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Lisa Schlicher

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Bing Dai

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Joshua C Bufton

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Sarah Picaud

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Jennifer A Ward

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Catherine Rogers

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Sameer Nikhar

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Gregory D Cuny

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Alex N Bullock

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publication date

19 July 2018

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volume

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issue

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describes a project that uses

13 April 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

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RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs

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Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide

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Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

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The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

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A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

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Mucosal NOD2 expression and NF-κB activation in pediatric Crohnʼs disease

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IRAK-4 kinase activity-dependent and -independent regulation of lipopolysaccharide-inducible genes

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The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals

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XIAP regulates cytosol-specific innate immunity to Listeria infection

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The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells.

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Activation of NOD2-mediated intestinal pathway in a pediatric population with Crohn's disease

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Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

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The kinase activity of Rip2 determines its stability and consequently Nod1- and Nod2-mediated immune responses

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ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways

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XIAP mediates NOD signaling via interaction with RIP2

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Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.

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Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity

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A new category of autoinflammatory disease associated with NOD2 gene mutations

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The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

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RIP2 activity in inflammatory disease and implications for novel therapeutics

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OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

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Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

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12 December 2020

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

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12 December 2020

X-linked inhibitor of apoptosis (XIAP) deficiency: the spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis.

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12 December 2020

NOD proteins: regulators of inflammation in health and disease

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A new functional assay for the diagnosis of X-linked inhibitor of apoptosis (XIAP) deficiency.

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NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.

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In vivo inhibition of RIPK2 kinase alleviates inflammatory disease

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Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation

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NOD1 and NOD2: signaling, host defense, and inflammatory disease

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Epidemiology and risk factors for IBD.

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A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

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Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1.

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FDA-approved small-molecule kinase inhibitors.

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A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.

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Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.

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From Genes to Mechanisms: The Expanding Spectrum of Monogenic Disorders Associated with Inflammatory Bowel Disease

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12 December 2020

Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes

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12 December 2020

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

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12 December 2020

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

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12 December 2020

The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase

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12 December 2020

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

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12 December 2020

SPOTing Acetyl-Lysine Dependent Interactions

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12 December 2020

Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease

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The role of hybrid ubiquitin chains in the MyD88 and other innate immune signalling pathways.

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12 December 2020

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists.

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12 December 2020

Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation

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The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation

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PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP.

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12 December 2020

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

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12 December 2020

ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.

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12 December 2020

Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer

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IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans

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Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling

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12 December 2020

Identifiers

DOI

10.15252/EMBJ.201899372

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13 April 2020

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13 April 2020

PubMed publication ID

30026309

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