Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus (Q90273872)

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English	Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus	scientific article published on 01 November 2019

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title

Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus (English)

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main subject

status epilepticus

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author

RJ Burman

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1

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Neela K Codadu

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6

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R Ryley Parrish

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9

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Joshua S Selfe

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John Hamin Lee

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3

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Maurits van den Berg

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4

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Alexandru Calin

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5

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Rebecca Wright

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Sarah E Newey

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8

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Arieh A Katz

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Jo M Wilmshurst

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11

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12 April 2020

Colin J Akerman

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12

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Andrew J Trevelyan

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13

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Joseph V Raimondo

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14

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publication date

1 November 2019

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published in

Brain

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volume

142

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issue

11

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page(s)

3482-3501

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Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus.

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KCC2 activity is critical in limiting the onset and severity of status epilepticus.

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Time from convulsive status epilepticus onset to anticonvulsant administration in children

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Ion dynamics during seizures

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Compromising KCC2 transporter activity enhances the development of continuous seizure activity.

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Tight Coupling of Astrocyte pH Dynamics to Epileptiform Activity Revealed by Genetically Encoded pH Sensors

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Dynamic, Cell-Type-Specific Roles for GABAergic Interneurons in a Mouse Model of Optogenetically Inducible Seizures.

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Neuronal Chloride Regulation via KCC2 Is Modulated through a GABAB Receptor Protein Complex.

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12 December 2020

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Seizing Control of KCC2: A New Therapeutic Target for Epilepsy.

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12 December 2020

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Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo.

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12 December 2020

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Flupirtine and diazepam combination terminates established status epilepticus: results in three rodent models

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12 December 2020

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Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus.

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12 December 2020

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Timing in the treatment of status epilepticus: From basics to the clinic

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12 December 2020

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Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis

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12 December 2020

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inferred from PubMed ID database lookup

Region-specific differences and areal interactions underlying transitions in epileptiform activity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31553050

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31553050

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Comparison of Parenteral Phenobarbital vs. Parenteral Phenytoin as Second-Line Management for Pediatric Convulsive Status Epilepticus in a Resource-Limited Setting.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31553050

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/BRAIN/AWZ283

1 reference

stated in

Europe PubMed Central

PubMed publication ID

31553050

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31553050%20AND%20SRC:MED&resulttype=core&format=json

retrieved

12 April 2020

PubMed publication ID

31553050

1 reference

stated in

Europe PubMed Central

PubMed publication ID

31553050

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31553050%20AND%20SRC:MED&resulttype=core&format=json

retrieved

12 April 2020

 

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