Increased expression of α-synuclein in aged human brain associated with neuromelanin accumulation (Q83774812)

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scientific article published on 03 April 2011

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English	Increased expression of α-synuclein in aged human brain associated with neuromelanin accumulation	scientific article published on 03 April 2011

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21461961

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title

Increased expression of α-synuclein in aged human brain associated with neuromelanin accumulation (English)

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Europe PubMed Central

PubMed publication ID

21461961

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27 January 2020

author name string

Qi Xuan

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1

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Europe PubMed Central

PubMed publication ID

21461961

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27 January 2020

Sheng-Li Xu

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2

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21461961

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27 January 2020

De-Hong Lu

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3

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21461961

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27 January 2020

Shun Yu

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4

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21461961

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27 January 2020

Ming Zhou

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5

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PubMed publication ID

21461961

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27 January 2020

Kenji Uéda

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6

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21461961

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27 January 2020

Ye-Qing Cui

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7

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PubMed publication ID

21461961

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27 January 2020

Bo-Yang Zhang

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8

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21461961

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27 January 2020

Piu Chan

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9

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PubMed publication ID

21461961

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27 January 2020

publication date

3 April 2011

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PubMed publication ID

21461961

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27 January 2020

published in

Journal of Neural Transmission

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PubMed publication ID

21461961

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27 January 2020

volume

118

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21461961

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27 January 2020

issue

11

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PubMed publication ID

21461961

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21461961%20AND%20SRC:MED&resulttype=core&format=json

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27 January 2020

page(s)

1575-1583

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21461961

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27 January 2020

cites work

Ageing of substantia nigra in humans: cell loss may be compensated by hypertrophy

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

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Silencing alpha-synuclein gene expression enhances tyrosine hydroxylase activity in MN9D cells

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

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Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

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Generation of reactive oxygen species by tyrosine hydroxylase: a possible contribution to the degeneration of dopaminergic neurons?

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

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Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

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Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

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Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

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Inhibition of tyrosine hydroxylase expression in alpha-synuclein-transfected dopaminergic neuronal cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

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A role for alpha-synuclein in the regulation of dopamine biosynthesis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

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α-Synuclein aggregation and neurodegenerative diseases

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of neuromelanin on oxidative pathways within the human substantia nigra

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21461961

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Synuclein locus triplication causes Parkinson's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

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The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

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The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unbiased stereological estimation of the number of neurons in the human hippocampus

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

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Low numbers and no loss of melanized nigral neurons with increasing age in normal human brains from India

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

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Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

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Aging of the nigrostriatal system in the squirrel monkey

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Residual substantia nigra neuromelanin in Parkinson's disease is cross-linked to alpha-synuclein

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

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Neuromelanin inhibits enzymatic activity of 26S proteasome in human dopaminergic SH-SY5Y cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New face of neuromelanin.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unbiased morphometrical measurements show loss of pigmented nigral neurones with ageing.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of peroxidase in neuromelanin synthesis: a review

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

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Autophagic stress in neuronal injury and disease.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

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Evidence for specific phases in the development of human neuromelanin

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

based on heuristic

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Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications.

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https://pubmed.ncbi.nlm.nih.gov/21461961

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12 December 2020

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Identifiers

DOI

10.1007/S00702-011-0636-3

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21461961

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21461961%20AND%20SRC:MED&resulttype=core&format=json

retrieved

27 January 2020

PubMed publication ID

21461961

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21461961

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21461961%20AND%20SRC:MED&resulttype=core&format=json

retrieved

27 January 2020

 

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