Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls (Q89694228)

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scientific article published on 13 February 2020

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English	Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls	scientific article published on 13 February 2020

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32053263%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32053263%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

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Vadim Le Joncour

2

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7 April 2020

7

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7 April 2020

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Johanna Eriksson

1

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7 April 2020

Tiina Jahkola

3

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7 April 2020

Susanna Juteau

4

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7 April 2020

Pirjo Laakkonen

5

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7 April 2020

Olli Saksela

6

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Europe PubMed Central

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7 April 2020

publication date

13 February 2020

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7 April 2020

Molecular Oncology

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7 April 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7138405/fullTextXML

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inferred from PubMed Central ID database lookup

Reversible inhibition of C1Q release from guinea pig macrophages by 2,2'-dipyridyl: Evidence for a posttranslational hydroxylation step in the biosynthesis of C1Q, a subcomponent of the first component of complement (C1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

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Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

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FGF expression allows nevus cells to survive in three-dimensional collagen gel under conditions that induce apoptosis in normal human melanocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significance analysis of microarrays applied to the ionizing radiation response

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

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Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversible regulation of the transformed phenotype of ornithine decarboxylase- and ras-overexpressing cells by dominant-negative mutants of c-Jun

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

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Human prolyl-4-hydroxylase alpha(I) transcription is mediated by upstream stimulatory factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Switch to an invasive growth phase in melanoma is associated with tenascin-C, fibronectin, and procollagen-I forming specific channel structures for invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dickkopf-1 activates cell death in MDA-MB435 melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia in cancer: significance and impact on clinical outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systematic search for the best gene expression markers for melanoma micrometastasis detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RhoC a new target for therapeutic vaccination against metastatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional context regulation of metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of RhoC in growth and metastatic capacity of melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

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Final version of 2009 AJCC melanoma staging and classification

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolyl 4-hydroxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

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Metastatic outgrowth encompasses COL-I, FN1, and POSTN up-regulation and assembly to fibrillar networks regulating cell adhesion, migration, and growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Melanoma cells produce multiple laminin isoforms and strongly migrate on α5 laminin(s) via several integrin receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of mitotic rate in localized primary cutaneous melanoma: an analysis of patients in the multi-institutional American Joint Committee on Cancer melanoma staging database

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor beta-induced (TGFBI) is an anti-adhesive protein regulating the invasive growth of melanoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dickkopf-1 inhibits the invasive activity of melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen prolyl hydroxylases are essential for breast cancer metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spire-1 contributes to the invadosome and its associated invasive properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Final trial report of sentinel-node biopsy versus nodal observation in melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The miR-124-prolyl hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIF-1 at the crossroads of hypoxia, inflammation, and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-independent drivers of melanoma angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe Extracellular Matrix Abnormalities and Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene Expression Signatures as Biomarkers of Tumour Hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative analysis of transcriptomics based hypoxia signatures in head- and neck squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CTHRC1 promotes angiogenesis by recruiting Tie2-expressing monocytes to pancreatic tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Knockdown of P4HA1 inhibits neovascularization via targeting glioma stem cell-endothelial cell transdifferentiation and disrupting vascular basement membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic therapy in advanced melanoma: integrating targeted therapy and immunotherapy into clinical practice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of P4HA1 as a prognostic biomarker for high-grade gliomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen triple helix repeat containing 1 promotes tumor angiogenesis in gastrointestinal stromal tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P4HA1: A single-gene surrogate of hypoxia signatures in oral squamous cell carcinoma patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The triple helix of collagens - an ancient protein structure that enabled animal multicellularity and tissue evolution.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen Prolyl 4-Hydroxylase as a Therapeutic Target.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ki67 is a Graded Rather than a Binary Marker of Proliferation versus Quiescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial-Mesenchymal Plasticity in Breast Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen Prolyl Hydroxylases Are Bifunctional Growth Regulators in Melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complexity of type IV collagens: from network assembly to function

1 reference

https://pubmed.ncbi.nlm.nih.gov/32053263

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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