Targeting Cancer Metabolism to Resensitize Chemotherapy: Potential Development of Cancer Chemosensitizers from Traditional Chinese Medicines (Q89682949)

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scientific article published on 10 February 2020

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English	Targeting Cancer Metabolism to Resensitize Chemotherapy: Potential Development of Cancer Chemosensitizers from Traditional Chinese Medicines	scientific article published on 10 February 2020

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7 April 2020

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Targeting Cancer Metabolism to Resensitize Chemotherapy: Potential Development of Cancer Chemosensitizers from Traditional Chinese Medicines (English)

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7 April 2020

traditional Chinese medicine

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traditional Chinese medicine

17 February 2024

author name string

Wei Guo

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Hor-Yue Tan

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7 April 2020

Feiyu Chen

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Ning Wang

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7 April 2020

Yibin Feng

5

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10 February 2020

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7 April 2020

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10 February 2020

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0 references

Tradition and perspectives of arab herbal medicine: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

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The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycolysis inhibition for anticancer treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread microRNA repression by Myc contributes to tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

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A change of strategy in the war on cancer

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

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The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

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Advanced pancreatic carcinoma: current treatment and future challenges

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

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Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant uptake of fatty acid over glucose by prostate cells: a potential new diagnostic and therapeutic approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

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CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances in early diagnosis and therapy of pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Otto Warburg's contributions to current concepts of cancer metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamine depletion and glucose depletion trigger growth inhibition via distinctive gene expression reprogramming

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gambogic acid sensitizes ovarian cancer cells to doxorubicin through ROS-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of overexpression of hexokinase II with chemoresistance in epithelial ovarian cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EpCAM expression in the prostate cancer makes the difference in the response to growth factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

β-elemene reverses the drug resistance of lung cancer A549/DDP cells via the mitochondrial apoptosis pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIF-1α and GLUT1 gene expression is associated with chemoresistance of acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of herbal medicines and natural products: an alternative approach to overcoming the apoptotic resistance of pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen-related receptor alpha confers methotrexate resistance via attenuation of reactive oxygen species production and P53 mediated apoptosis in osteosarcoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Baicalein reverses hypoxia-induced 5-FU resistance in gastric cancer AGS cells through suppression of glycolysis and the PTEN/Akt/HIF-1α signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro Study of the Antagonistic Effect of Low-dose Liquiritigenin on Gemcitabine-induced Capillary Leak Syndrome in Pancreatic Adenocarcinoma via Inhibiting ROS- Mediated Signalling Pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic strategies targeting cancer stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MYC, Metabolism, and Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Emerging Hallmarks of Cancer Metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Furanodiene alters mitochondrial function in doxorubicin-resistant MCF-7 human breast cancer cells in an AMPK-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy: Preventing competitive release

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms for tumor resistance to chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered glutamine metabolism in platinum resistant ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactivation of mutant p53 by capsaicin, the major constituent of peppers

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Salvianolic acid B reverses multidrug resistance in HCT‑8/VCR human colorectal cancer cells by increasing ROS levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Typical Metabolic Modifiers Conferring Improvement in Cancer Resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PRPS1 silencing reverses cisplatin resistance in human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gut microbiota modulation of chemotherapy efficacy and toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The heterogeneity of cancer stem-like cells at the invasive front

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microbiota: a key orchestrator of cancer therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Melittin inhibits tumor growth and decreases resistance to gemcitabine by downregulating cholesterol pathway gene CLU in pancreatic ductal adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of traditional Chinese medicine components on multidrug resistance in tumors mediated by P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dahuang Zhechong Pill Combined with Doxorubicin Induces Cell Death through Regulating Energy Metabolism in Human Hepatocellular Carcinoma Cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol esterification inhibition and gemcitabine synergistically suppress pancreatic ductal adenocarcinoma proliferation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenethyl Isothiocyanate Induces Apoptotic Cell Death Through the Mitochondria-dependent Pathway in Gefitinib-resistant NCI-H460 Human Lung Cancer Cells In Vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Dahuang zhechong pill on doxorubicin-resistant SMMC-7721 xenografts in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolomics of oncogene-specific metabolic reprogramming during breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical Effectiveness and Potential Survival Benefit of US-Guided High-Intensity Focused Ultrasound Therapy in Patients with Advanced-Stage Pancreatic Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolomics analysis of the potential anticancer mechanism of annonaceous acetogenins on a multidrug resistant mammary adenocarcinoma cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic vulnerability of cisplatin-resistant cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abrogation of glutathione peroxidase-1 drives EMT and chemoresistance in pancreatic cancer by activating ROS-mediated Akt/GSK3β/Snail signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging roles of Myc in stem cell biology and novel tumor therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid Droplets in Cancer: Guardians of Fat in a Stressful World

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC)

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rewiring of cisplatin-resistant bladder cancer cells through epigenetic regulation of genes involved in amino acid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyruvate dehydrogenase kinase 1 contributes to cisplatin resistance of ovarian cancer through EGFR activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibition of thymidine phosphorylase can reverse acquire 5FU resistance in gastric cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of SESN1 reduces cisplatin and hyperthermia resistance through increasing reactive oxygen species (ROS) in human maxillary cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione S‑transferase isozyme alpha 1 is predominantly involved in the cisplatin resistance of common types of solid cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulating ROS to overcome multidrug resistance in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting glycometabolic reprogramming to restore the sensitivity of leukemia drug-resistant K562/ADM cells to adriamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rhein reverses doxorubicin resistance in SMMC-7721 liver cancer cells by inhibiting energy metabolism and inducing mitochondrial permeability transition pore opening

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of multidrug resistance in breast cancer cells by a combination of ursolic acid with doxorubicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isofuranodiene synergizes with temozolomide in inducing glioma cells death

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-breast Cancer Enhancement of a Polysaccharide From Spore of With Paclitaxel: Suppression on Tumor Metabolism With Gut Microbiota Reshaping

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting lipid metabolism to overcome EMT-associated drug resistance via integrin β3/FAK pathway and tumor-associated macrophage repolarization using legumain-activatable delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phillygenin Exerts In Vitro and In Vivo Antitumor Effects in Drug-Resistant Human Esophageal Cancer Cells by Inducing Mitochondrial-Mediated Apoptosis, ROS Generation, and Inhibition of the Nuclear Factor kappa B NF-κB Signalling Pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trichostatin A modulates cellular metabolism in renal cell carcinoma to enhance sunitinib sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of proliferation and activation of cell death by sodium selenite involves mitochondria and lysosomes in chemoresistant bladder cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid receptor GPR120 promotes breast cancer chemoresistance by upregulating ABC transporters expression and fatty acid synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Energy metabolism is co-determined by genetic variants in chronic lymphocytic leukemia and influences drug sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Study of Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase (DPD) Expressions on 5-Fluorouracil in Oral Squamous Cell Carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Sensitizes Glioma Cells to Hypoxia, Irradiation and Temozolomide

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity of isoflavones and biflavonoids from Ormocarpum kirkii towards multi-factorial drug resistant cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose transporter 1 regulates the proliferation and cisplatin sensitivity of esophageal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Usnea Acid as Multidrug Resistance (MDR) Reversing Agent against Human Chronic Myelogenous Leukemia K562/ADR Cells via an ROS Dependent Apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-Lactate dehydrogenase B may be a predictive marker for sensitivity to anti-EGFR monoclonal antibodies in colorectal cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-type-specific sensitivity of bortezomib in the methotrexate-resistant primary central nervous system lymphoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione Peroxidase 1 Promotes NSCLC Resistance to Cisplatin via ROS-Induced Activation of PI3K/AKT Pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemosensitizing activity of Cuban propolis and nemorosone in doxorubicin resistant human colon carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The roles of glucose metabolic reprogramming in chemo- and radio-resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NAMPT regulates PKM2 nuclear location through 14-3-3ζ: Conferring resistance to tamoxifen in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting lactate dehydrogenase‑A promotes docetaxel‑induced cytotoxicity predominantly in castration‑resistant prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial complex I inhibitor deguelin induces metabolic reprogramming and sensitizes vemurafenib-resistant BRAFV600E mutation bearing metastatic melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adipocyte and lipid metabolism in cancer drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of Catechol-Type Diphenylbutadiene as a Tyrosinase-Activated Pro-oxidative Chemosensitizer against Melanoma A375 Cells via Glutathione S-Transferase Inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting Myeloperoxidase Disrupts Mitochondrial Redox Balance and Overcomes Cytarabine Resistance in Human Acute Myeloid Leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integration of Metabolomics and Transcriptomics To Reveal Metabolic Characteristics and Key Targets Associated with Cisplatin Resistance in Nonsmall Cell Lung Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer Metabolism and the Evasion of Apoptotic Cell Death

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oridonin overcomes the gemcitabine resistant PANC-1/Gem cells by regulating GST pi and LRP/1 ERK/JNK signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hexokinase 2 dimerization and interaction with voltage-dependent anion channel promoted resistance to cell apoptosis induced by gemcitabine in pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissecting molecular mechanisms of resistance to Notch1-targeted therapy in T-cell acute lymphoblastic leukemia xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/32050640

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/CANCERS12020404

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32050640%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32050640%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32050640%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

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