Mitochondrial function in the heart: the insight into mechanisms and therapeutic potentials (Q89397986)

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4 April 2020

title

Mitochondrial function in the heart: the insight into mechanisms and therapeutic potentials (English)

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4 April 2020

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4 April 2020

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4 April 2020

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4 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29968316%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

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4 April 2020

Lucy Collins

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4 April 2020

publication date

2 August 2018

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British Journal of Pharmacology

4 April 2020

published in

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4 April 2020

volume

176

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4 April 2020

issue

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4 April 2020

page(s)

4302-4318

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Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress

4 April 2020

cites work

1 reference

12 December 2020

Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts.

1 reference

12 December 2020

Dichloroacetate as metabolic therapy for myocardial ischemia and failure

1 reference

12 December 2020

Combination treatment with trimetazidine and diltiazem in stable angina pectoris

1 reference

12 December 2020

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

1 reference

12 December 2020

Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure

1 reference

12 December 2020

Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

1 reference

12 December 2020

Lipid-assisted protein folding

1 reference

12 December 2020

The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase

1 reference

12 December 2020

An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle

1 reference

12 December 2020

Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles.

1 reference

12 December 2020

The development of myocardial insulin resistance in conscious dogs with advanced dilated cardiomyopathy

1 reference

12 December 2020

Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection

1 reference

12 December 2020

The ETS transcription factor GABPalpha is essential for early embryogenesis

1 reference

12 December 2020

Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion

1 reference

12 December 2020

Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway

1 reference

12 December 2020

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

1 reference

12 December 2020

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

1 reference

12 December 2020

Disruption of fusion results in mitochondrial heterogeneity and dysfunction

1 reference

12 December 2020

Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarction

1 reference

12 December 2020

Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment

1 reference

12 December 2020

Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP.

1 reference

12 December 2020

EUK-8, a Superoxide Dismutase and Catalase Mimetic, Reduces Cardiac Oxidative Stress and Ameliorates Pressure Overload-Induced Heart Failure in the Harlequin Mouse Mutant

1 reference

12 December 2020

Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failure

1 reference

12 December 2020

Mitochondrial bioenergetics and structural network organization

1 reference

12 December 2020

A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation

1 reference

12 December 2020

Overexpression of IAP-2 attenuates apoptosis and protects against myocardial ischemia/reperfusion injury in transgenic mice

1 reference

12 December 2020

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

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12 December 2020

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

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12 December 2020

Preconditioning results in S-nitrosylation of proteins involved in regulation of mitochondrial energetics and calcium transport

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12 December 2020

Heart mitochondria: gates of life and death

1 reference

12 December 2020

A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations

1 reference

12 December 2020

Effect of cyclosporine on reperfusion injury in acute myocardial infarction

1 reference

12 December 2020

Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial

1 reference

12 December 2020

Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure

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12 December 2020

Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice

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12 December 2020

Mitochondrial OPA1, apoptosis, and heart failure

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12 December 2020

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

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12 December 2020

A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury.

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12 December 2020

The Randle cycle revisited: a new head for an old hat.

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12 December 2020

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

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12 December 2020

Antioxidant, EUK-8, Prevents Murine Dilated Cardiomyopathy

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12 December 2020

Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels

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12 December 2020

S-nitrosylation in cardiovascular signaling

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12 December 2020

Therapeutic targeting of mitochondrial superoxide in hypertension

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12 December 2020

Phosphoproteome analysis reveals regulatory sites in major pathways of cardiac mitochondria

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12 December 2020

PGC-1 Coactivators in Cardiac Development and Disease

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12 December 2020

Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition

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12 December 2020

Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice

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12 December 2020

Silent information regulator 1 protects the heart from ischemia/reperfusion

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12 December 2020

Trimetazidine: a meta-analysis of randomised controlled trials in heart failure

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12 December 2020

Mitochondrial cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure

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12 December 2020

Adenine nucleotide translocase 1 deficiency results in dilated cardiomyopathy with defects in myocardial mechanics, histopathological alterations, and activation of apoptosis

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12 December 2020

Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure

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12 December 2020

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function

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12 December 2020

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

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12 December 2020

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

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12 December 2020

Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1.

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12 December 2020

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

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12 December 2020

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

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12 December 2020

Fusion and fission: interlinked processes critical for mitochondrial health

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12 December 2020

AMP-activated protein kinase regulation and biological actions in the heart

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12 December 2020

Targeting mitochondrial oxidative metabolism as an approach to treat heart failure

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12 December 2020

Physiological roles of the permeability transition pore

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12 December 2020

Reduction of ischemia/reperfusion injury with bendavia, a mitochondria-targeting cytoprotective Peptide

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12 December 2020

Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction

1 reference

12 December 2020

Efficacy of trimetazidine on functional capacity in symptomatic patients with stable exertional angina--the VASCO-angina study

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12 December 2020

Mitochondria as a therapeutic target in heart failure

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12 December 2020

Phosphatidylethanolamine deficiency in Mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology

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12 December 2020

OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability

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12 December 2020

Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup

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12 December 2020

Dimers of mitochondrial ATP synthase form the permeability transition pore

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12 December 2020

Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury.

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12 December 2020

Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.

1 reference

12 December 2020

Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides

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12 December 2020

Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes

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12 December 2020

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

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12 December 2020

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.

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12 December 2020

Taking diabetes to heart--deregulation of myocardial lipid metabolism in diabetic cardiomyopathy

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12 December 2020

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

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12 December 2020

Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases

1 reference

12 December 2020

SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts

1 reference

12 December 2020

Necrostatin-1 inhibits Hmgb1-IL-23/IL-17 pathway and attenuates cardiac ischemia reperfusion injury

1 reference

12 December 2020

Downregulation of Sirt1 as aging change in advanced heart failure

1 reference

12 December 2020

Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo

1 reference

12 December 2020

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

1 reference

12 December 2020

Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results.

1 reference

12 December 2020

Cyclophilin D and myocardial ischemia-reperfusion injury: a fresh perspective.

1 reference

12 December 2020

Mending a broken heart: the role of mitophagy in cardioprotection

1 reference

12 December 2020

Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats

1 reference

12 December 2020

GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts

1 reference

12 December 2020

Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor α.

1 reference

12 December 2020

Physiological and pathological roles of the mitochondrial permeability transition pore in the heart

1 reference

12 December 2020

Trimetazidine in Practice: Review of the Clinical and Experimental Evidence

1 reference

12 December 2020

Emerging concepts in the therapy of mitochondrial disease

1 reference

12 December 2020

Caspase functions in cell death and disease

1 reference

12 December 2020

Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease

1 reference

12 December 2020

How mitochondrial dynamism orchestrates mitophagy

1 reference

12 December 2020

Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts

1 reference

12 December 2020

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes

1 reference

12 December 2020

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure.

1 reference

12 December 2020

Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore.

1 reference

12 December 2020

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

1 reference

12 December 2020

Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats

1 reference

12 December 2020

EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention

1 reference

12 December 2020

N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

1 reference

12 December 2020

Impaired mitochondrial biogenesis is a common feature to myocardial hypertrophy and end-stage ischemic heart failure

1 reference

12 December 2020

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

1 reference

12 December 2020

Inhibition of Receptor Interacting Protein Kinases Attenuates Cardiomyocyte Hypertrophy Induced by Palmitic Acid

1 reference

12 December 2020

Administration of antioxidant peptide SS-31 attenuates transverse aortic constriction-induced pulmonary arterial hypertension in mice

1 reference

12 December 2020

Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association.

1 reference

12 December 2020

Enjoy the Trip: Calcium in Mitochondria Back and Forth

1 reference

12 December 2020

Dietary epicatechin intake and 25-y risk of cardiovascular mortality: the Zutphen Elderly Study

1 reference

12 December 2020

Mitochondrial lipid transport and biosynthesis: A complex balance

1 reference

12 December 2020

MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

1 reference

12 December 2020

Mitoprotective antioxidant EUK-134 stimulates fatty acid oxidation and prevents hypertrophy in H9C2 cells

1 reference

12 December 2020

The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent

1 reference

12 December 2020

Necroptosis: Mechanisms and Relevance to Disease

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12 December 2020

Expert consensus document: Mitochondrial function as a therapeutic target in heart failure

1 reference

12 December 2020

Superoxide dismutase/catalase mimetic EUK-134 prevents diaphragm muscle weakness in monocrotalin-induced pulmonary hypertension

1 reference

12 December 2020

Mff-Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS-Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation-Involved mPTP Opening

1 reference

12 December 2020

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase

1 reference

12 December 2020

Catechins as Potential Mediators of Cardiovascular Health

1 reference

12 December 2020

Mitochondrial permeability transition in cardiac ischemia-reperfusion: whether cyclophilin D is a viable target for cardioprotection?

1 reference

12 December 2020

FKBP8 recruits LC3A to mediate Parkin-independent mitophagy.

1 reference

12 December 2020

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

1 reference

12 December 2020

High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities

1 reference

12 December 2020

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

1 reference

12 December 2020

Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling.

1 reference

12 December 2020

The therapeutic potential of resveratrol: a review of clinical trials.

1 reference

12 December 2020

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Nuclear hormone receptors.

1 reference

12 December 2020

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes

1 reference

12 December 2020

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Transporters

1 reference

12 December 2020

Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence

1 reference

12 December 2020

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.

1 reference

12 December 2020

DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways

1 reference

12 December 2020

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.

1 reference

12 December 2020

Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide

1 reference

12 December 2020

AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation

1 reference

12 December 2020

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

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12 December 2020

MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload

1 reference

12 December 2020

Mitochondrial Fission Is Required for Angiotensin II-Induced Cardiomyocyte Apoptosis Mediated by a Sirt1-p53 Signaling Pathway.

1 reference

12 December 2020

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults.

1 reference

12 December 2020

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults

1 reference

12 December 2020

Identifiers

DOI

10.1111/BPH.14431

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29968316%20AND%20SRC:MED&resulttype=core&format=json

4 April 2020

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4 April 2020

PubMed publication ID

29968316

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