Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis (Q89171393)

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scientific article published on 01 July 2018

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English	Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis	scientific article published on 01 July 2018

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1 April 2020

Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis (English)

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Brian A. Ference

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Børge G. Nordestgaard

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Anne Tybjærg-Hansen

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Pia R. Kamstrup

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Stephen Burgess

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James R Staley

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Daniel F Freitag

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Amy M Mason

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Sune F Nielsen

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Peter Willeit

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Robin Young

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Praveen Surendran

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Savita Karthikeyan

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Thomas R Bolton

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James E Peters

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Anne Langsted

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Camilla J Kobylecki

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Chris Packard

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1 April 2020

Emanuele Di Angelantonio

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Danish Saleheen

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1 April 2020

Joanna M M Howson

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Adam S Butterworth

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1 April 2020

European Prospective Investigation Into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD) Consortium

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1 April 2020

publication date

1 July 2018

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1 April 2020

JAMA cardiology

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1 April 2020

3

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1 April 2020

7

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1 April 2020

619-627

1 reference

Europe PubMed Central

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1 April 2020

Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

based on heuristic

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Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

based on heuristic

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Lipoprotein(a) as a risk factor for coronary artery disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of torcetrapib in patients at high risk for coronary events

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

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Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population: the Copenhagen City Heart Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

based on heuristic

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Lipoprotein(a) levels and risk of future coronary heart disease: large-scale prospective data

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

based on heuristic

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Genetically elevated lipoprotein(a) and increased risk of myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

based on heuristic

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Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

based on heuristic

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Major lipids, apolipoproteins, and risk of vascular disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

based on heuristic

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Genetic variants associated with Lp(a) lipoprotein level and coronary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

based on heuristic

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Biological, clinical and population relevance of 95 loci for blood lipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

based on heuristic

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Lipoprotein(a) as a cardiovascular risk factor: current status

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

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Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

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Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

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The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

1 reference

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12 December 2020

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Effects of extended-release niacin with laropiprant in high-risk patients

1 reference

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12 December 2020

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Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: a 2 × 2 factorial Mendelian randomization study

1 reference

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A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

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Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods

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High lipoprotein(a) as a possible cause of clinical familial hypercholesterolaemia: a prospective cohort study

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https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

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Prevalence of Elevated Lp(a) Mass Levels and Patient Thresholds in 532 359 Patients in the United States

1 reference

https://pubmed.ncbi.nlm.nih.gov/29926099

12 December 2020

based on heuristic

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Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials

1 reference

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Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis

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12 December 2020

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Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology

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https://pubmed.ncbi.nlm.nih.gov/29926099

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Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes

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Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels

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1 reference

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Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease

1 reference

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12 December 2020

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Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk

1 reference

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12 December 2020

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Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

1 reference

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High Lipoprotein(a) and Low Risk of Major Bleeding in Brain and Airways in the General Population: a Mendelian Randomization Study

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1 reference

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12 December 2020

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Impact of Apolipoprotein(a) Isoform Size on Lipoprotein(a) Lowering in the HPS2-THRIVE Study

1 reference

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10.1001/JAMACARDIO.2018.1470

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1 April 2020

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1 April 2020

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1 April 2020

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