Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications (Q88090581)

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20 March 2020

title

Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications (English)

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20 March 2020

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20 March 2020

Stefan K Plontke

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20 March 2020

publication date

11 March 2018

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20 March 2020

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volume

368

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20 March 2020

page(s)

28-40

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Macromolecular transport by the middle ear and its lymphatic system

20 March 2020

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Ablation therapy for the relief of Ménière's disease

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Long-Term Evaluation of the Effect of Intracochlear Steroid Deposition on Electrode Impedance in Cochlear Implant Patients

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Transtympanic injection of anesthetics for the treatment of Méniére's syndrome.

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Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: a comparison of their glucocorticoid and mineralocorticoid properties

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Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsule

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Changes of postoperative impedances in cochlear implant patients: the short-term effects of modified electrode surfaces and intracochlear corticosteroids

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Application of a corticosteroid (Triamcinolon) protects inner ear function after surgical intervention

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Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph

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Dexamethasone concentration gradients along scala tympani after application to the round window membrane

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12 December 2020

Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on: Bird PA, Begg EJ, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol 2007;28:1124-30.

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Issues, indications, and controversies regarding intratympanic steroid perfusion

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Inner ear drug delivery for auditory applications

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Entry of substances into perilymph through the bone of the otic capsule after intratympanic applications in guinea pigs: implications for local drug delivery in humans.

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Principles of local drug delivery to the inner ear.

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Dose-dependent sustained release of dexamethasone in inner ear cochlear fluids using a novel local delivery approach

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Corticosteroid-releasing cochlear implant: a novel hybrid of biomaterial and drug delivery system

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12 December 2020

Principles of inner ear sustained release following intratympanic administration

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12 December 2020

Kinetics of reciprocating drug delivery to the inner ear

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12 December 2020

Direct entry of gadolinium into the vestibule following intratympanic applications in Guinea pigs and the influence of cochlear implantation

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Nanoparticle-based delivery for the treatment of inner ear disorders

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12 December 2020

Uptake of gentamicin by vestibular efferent neurons and superior olivary complex after transtympanic administration in guinea pigs.

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12 December 2020

Marker entry into vestibular perilymph via the stapes following applications to the round window niche of guinea pigs

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12 December 2020

Dexamethasone levels and base-to-apex concentration gradients in the scala tympani perilymph after intracochlear delivery in the guinea pig.

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Local drug delivery to the inner ear using biodegradable materials.

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12 December 2020

Perilymph pharmacokinetics of markers and dexamethasone applied and sampled at the lateral semi-circular canal.

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Corticosteroid therapy for hearing and balance disorders

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Chronic neurotrophin delivery promotes ectopic neurite growth from the spiral ganglion of deafened cochleae without compromising the spatial selectivity of cochlear implants.

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Dual origin of the epithelium of the mammalian middle ear.

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12 December 2020

Gentamicin administration on the stapes footplate causes greater hearing loss and vestibulotoxicity than round window administration in guinea pigs

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12 December 2020

Tympanotomy with sealing of the round window as surgical salvage option in sudden idiopathic sensorineural hearing loss

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12 December 2020

OTO-201: nonclinical assessment of a sustained-release ciprofloxacin hydrogel for the treatment of otitis media

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Dexamethasone eluting electrodes for cochlear implantation: Effect on residual hearing

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12 December 2020

Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss

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12 December 2020

The role of intracochlear drug delivery devices in the management of inner ear disease

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12 December 2020

Treating hearing disorders with cell and gene therapy

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12 December 2020

Effects of intraoperatively applied glucocorticoid hydrogels on residual hearing and foreign body reaction in a guinea pig model of cochlear implantation

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12 December 2020

Perilymph Kinetics of FITC-Dextran Reveals Homeostasis Dominated by the Cochlear Aqueduct and Cerebrospinal Fluid.

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12 December 2020

Intrathecal 2-hydroxypropyl-beta-cyclodextrin in a single patient with Niemann-Pick C1.

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12 December 2020

Dose Effect of Intratympanic Dexamethasone for Idiopathic Sudden Sensorineural Hearing Loss: 24 mg/mL Is Superior to 10 mg/mL.

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12 December 2020

In vitro and in vivo pharmacokinetic study of a dexamethasone-releasing silicone for cochlear implants

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12 December 2020

Impedance Changes and Fibrous Tissue Growth after Cochlear Implantation Are Correlated and Can Be Reduced Using a Dexamethasone Eluting Electrode

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12 December 2020

Intracochlear Drug Injections through the Round Window Membrane: Measures to Improve Drug Retention.

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12 December 2020

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

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12 December 2020

Perilymph pharmacokinetics of locally-applied gentamicin in the guinea pig.

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12 December 2020

Intratympanic Sustained-Exposure Dexamethasone Thermosensitive Gel for Symptoms of Ménière's Disease: Randomized Phase 2b Safety and Efficacy Trial

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12 December 2020

Hearing Changes After Intratympanically Applied Steroids for Primary Therapy of Sudden Hearing Loss: A Meta-analysis Using Mathematical Simulations of Drug Delivery Protocols.

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12 December 2020

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12 December 2020

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12 December 2020

Intratympanic Triamcinolone and Dexamethasone in the Treatment of Ménière's Syndrome.

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12 December 2020

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Diagnostics and Therapy of Idiopathic Sudden Sensorineural Hearing Loss

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NANOCI-Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons.

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12 December 2020

Perilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs.

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12 December 2020

Local inner ear application of dexamethasone in cochlear implant models is safe for auditory neurons and increases the neuroprotective effect of chronic electrical stimulation

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12 December 2020

The Role of High Dose Intratympanic Dexamethasone as Salvage Therapy for Idiopathic Sudden Sensorineural Hearing Loss

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12 December 2020

Communication pathways to and from the inner ear and their contributions to drug delivery.

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12 December 2020

10.1016/J.HEARES.2018.03.002

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29551306%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

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20 March 2020

PubMed publication ID

29551306

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