Challenges and approaches to understand cholesterol-binding impact on membrane protein function: an NMR view (Q88008349)

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19 March 2020

title

Challenges and approaches to understand cholesterol-binding impact on membrane protein function: an NMR view (English)

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19 March 2020

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19 March 2020

Garima Jaipuria

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19 March 2020

Tina Ukmar-Godec

series ordinal

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19 March 2020

publication date

8 March 2018

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Cellular and Molecular Life Sciences

19 March 2020

published in

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19 March 2020

volume

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19 March 2020

issue

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19 March 2020

page(s)

2137-2151

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Immobilized lipid in acetylcholine receptor-rich membranes from Torpedo marmorata

19 March 2020

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Interaction of the Acetylcholine (Nicotinic) Receptor Protein from Torpedo marmorata Electric Organ with Monolayers of Pure Lipids

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Juxtamembrane protein segments that contribute to recruitment of cholesterol into domains

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12 December 2020

Cholesterol modulates the volume-regulated anion current in Ehrlich-Lettre ascites cells via effects on Rho and F-actin

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12 December 2020

Roles of bilayer material properties in function and distribution of membrane proteins

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12 December 2020

Peptides in lipid bilayers: the power of simple models

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12 December 2020

Voltage gating of VDAC is regulated by nonlamellar lipids of mitochondrial membranes

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12 December 2020

Conformational flexibility and strand arrangements of the membrane-associated HIV fusion peptide trimer probed by solid-state NMR spectroscopy

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12 December 2020

Sterol carrier protein-2: new roles in regulating lipid rafts and signaling

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12 December 2020

Tilted properties of the 67-78 fragment of α-synuclein are responsible for membrane destabilization and neurotoxicity

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12 December 2020

The voltage dependent anion channel affects mitochondrial cholesterol distribution and function

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12 December 2020

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

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12 December 2020

Cholesterol effects on nicotinic acetylcholine receptor

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The second transmembrane domain of the large conductance, voltage- and calcium-gated potassium channel beta(1) subunit is a lithocholate sensor

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The impact of peptides on lipid membranes.

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12 December 2020

Relationships between the orientation and the structural properties of peptides and their membrane interactions.

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12 December 2020

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

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12 December 2020

Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.

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12 December 2020

Regulation of hexokinase binding to VDAC

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12 December 2020

Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent Micelles

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12 December 2020

Embedded cholesterol in the nicotinic acetylcholine receptor

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12 December 2020

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

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12 December 2020

Structure of the human voltage-dependent anion channel

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12 December 2020

Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states.

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12 December 2020

Structure and mechanism of beta-hairpin antimicrobial peptides in lipid bilayers from solid-state NMR spectroscopy.

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12 December 2020

Immobilization of the influenza A M2 transmembrane peptide in virus envelope-mimetic lipid membranes: a solid-state NMR investigation

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12 December 2020

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

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12 December 2020

Electron spin resonance in membrane research: protein-lipid interactions from challenging beginnings to state of the art.

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12 December 2020

Cholesterol and ion channels

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12 December 2020

VDAC, a multi-functional mitochondrial protein regulating cell life and death

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12 December 2020

Membrane interactions of oligomeric alpha-synuclein: potential role in Parkinson's disease

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12 December 2020

Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals

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12 December 2020

Influence of solubilizing environments on membrane protein structures

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12 December 2020

Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases

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12 December 2020

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

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12 December 2020

Identification of cholesterol recognition amino acid consensus (CRAC) motif in G-protein coupled receptors

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12 December 2020

Specificity of cholesterol and analogs to modulate BK channels points to direct sterol-channel protein interactions

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12 December 2020

Functional characterization of putative cholesterol binding sequence (CRAC) in human type-1 cannabinoid receptor

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12 December 2020

Identification of a Binding Motif in the S5 Helix That Confers Cholesterol Sensitivity to the TRPV1 Ion Channel

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12 December 2020

Crystal structure of the eukaryotic light-driven proton-pumping rhodopsin, Acetabularia rhodopsin II, from marine alga

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12 December 2020

The fusogenic tilted peptide (67-78) of α-synuclein is a cholesterol binding domain

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12 December 2020

Cholesterol regulates prokaryotic Kir channel by direct binding to channel protein

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12 December 2020

The role of the lipid matrix for structure and function of the GPCR rhodopsin

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12 December 2020

The music of lipids: how lipid composition orchestrates cellular behaviour

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12 December 2020

The role of lipids in VDAC oligomerization

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12 December 2020

Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor.

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12 December 2020

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

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12 December 2020

Multiple cholesterol recognition/interaction amino acid consensus (CRAC) motifs in cytosolic C tail of Slo1 subunit determine cholesterol sensitivity of Ca2+- and voltage-gated K+ (BK) channels

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12 December 2020

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

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12 December 2020

Membrane lipid composition regulates tubulin interaction with mitochondrial voltage-dependent anion channel

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12 December 2020

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12 December 2020

Alpha-synuclein pore forming activity upon membrane association

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12 December 2020

Translocator protein (18 kDa) (TSPO) as a therapeutic target for anxiety and neurologic disorders

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12 December 2020

Predictions for cholesterol interaction sites on the A2A adenosine receptor

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12 December 2020

Stabilization of functional recombinant cannabinoid receptor CB(2) in detergent micelles and lipid bilayers.

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12 December 2020

Identification of cholesterol binding sites in the serotonin1A receptor.

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12 December 2020

Mapping the functional binding sites of cholesterol in β2-adrenergic receptor by long-time molecular dynamics simulations

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12 December 2020

Rhodopsin-lipid interactions studied by NMR.

1 reference

12 December 2020

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

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12 December 2020

Influences of membrane mimetic environments on membrane protein structures.

1 reference

12 December 2020

Biochemical identification of a linear cholesterol-binding domain within Alzheimer's β amyloid peptide

1 reference

12 December 2020

Structural Features for Functional Selectivity at Serotonin Receptors

1 reference

12 December 2020

Cholesterol accelerates the binding of Alzheimer's β-amyloid peptide to ganglioside GM1 through a universal hydrogen-bond-dependent sterol tuning of glycolipid conformation

1 reference

12 December 2020

Mitochondrial membrane lipid remodeling in pathophysiology: a new target for diet and therapeutic interventions.

1 reference

12 December 2020

Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein

1 reference

12 December 2020

A distinct mechanism for activating uncoupled nicotinic acetylcholine receptors

1 reference

12 December 2020

Identification of novel cholesterol-binding regions in Kir2 channels

1 reference

12 December 2020

Conformational analysis of the full-length M2 protein of the influenza A virus using solid-state NMR.

1 reference

12 December 2020

X-ray structure of dopamine transporter elucidates antidepressant mechanism

1 reference

12 December 2020

Non-covalent binding of membrane lipids to membrane proteins.

1 reference

12 December 2020

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

1 reference

12 December 2020

Solid-state NMR spectroscopy to study protein-lipid interactions

1 reference

12 December 2020

Serial Femtosecond Crystallography of G Protein-Coupled Receptors

1 reference

12 December 2020

Structure of the mitochondrial translocator protein in complex with a diagnostic ligand

1 reference

12 December 2020

Cholesterol modulates the dimer interface of the β₂-adrenergic receptor via cholesterol occupancy sites

1 reference

12 December 2020

A predicted binding site for cholesterol on the GABAA receptor

1 reference

12 December 2020

Structural insights into functional lipid-protein interactions in secondary transporters

1 reference

12 December 2020

Computational investigation of cholesterol binding sites on mitochondrial VDAC.

1 reference

12 December 2020

Role of lipid-mediated effects in β₂-adrenergic receptor dimerization

1 reference

12 December 2020

Two classes of cholesterol binding sites for the β2AR revealed by thermostability and NMR.

1 reference

12 December 2020

Molecular dynamics simulations of GPCR-cholesterol interaction: An emerging paradigm

1 reference

12 December 2020

The influence of cholesterol on membrane protein structure, function, and dynamics studied by molecular dynamics simulations.

1 reference

12 December 2020

Structural Integrity of the A147T Polymorph of Mammalian TSPO

1 reference

12 December 2020

Lost in translocation: the functions of the 18-kD translocator protein

1 reference

12 December 2020

Conformational Flexibility in the Transmembrane Protein TSPO

1 reference

12 December 2020

Cholesterol-Dependent Conformational Exchange of the C-Terminal Domain of the Influenza A M2 Protein

1 reference

12 December 2020

Lipid-Protein Interactions in the Regulated Betaine Symporter BetP Probed by Infrared Spectroscopy.

1 reference

12 December 2020

Nanodiscs for structural and functional studies of membrane proteins

1 reference

12 December 2020

Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure

1 reference

12 December 2020

Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.

1 reference

12 December 2020

Common structural features of cholesterol binding sites in crystallized soluble proteins

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12 December 2020

Soft Matter in Lipid-Protein Interactions

1 reference

12 December 2020

Structure of the human multidrug transporter ABCG2.

1 reference

12 December 2020

Lipid Internal Dynamics Probed in Nanodiscs

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12 December 2020

Cholesterol-binding site of the influenza M2 protein in lipid bilayers from solid-state NMR.

1 reference

12 December 2020

10.1007/S00018-018-2789-9

Identifiers

DOI

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19 March 2020

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