ruxolitinib (Q7383611)

Ruxolitinib (English)

(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

19 October 2016

stereoisomer of

2 references

based on heuristic

inferred from InChIKey

based on heuristic

inferred from InChI

chemical formula

C₁₇H₁₈N₆

1 reference

Ruxolitinib (English)

20 November 2016

canonical SMILES

C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

1 reference

Ruxolitinib (English)

20 November 2016

isomeric SMILES

C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

1 reference

World Health Organisation international non-proprietary name

Ruxolitinib (English)

20 November 2016

1 reference

14 February 2018

ruxolitinib (English)

2 references

ruxolitinib (English)

medical condition treated

19 October 2016

published in

Recommended INN: List 65

publication date

2011

thrombogavitis

1 reference

2 October 2018

leukemia

1 reference

hematopoietic system disease

2 October 2018

1 reference

2 October 2018

thrombocytopenia

1 reference

2 October 2018

myelodysplastic syndrome

1 reference

2 October 2018

polycythemia vera

1 reference

graft-versus-host disease

2 October 2018

1 reference

2 October 2018

polycythemia

1 reference

2 October 2018

acute myeloid leukemia

1 reference

2 October 2018

myelofibrosis

1 reference

2 October 2018

essential thrombocytosis

1 reference

significant drug interaction

2 October 2018

idelalisib

side effect

bone marrow failure

1 reference

sourcing circumstances

hypothetically

A reference set of clinically relevant adverse drug-drug interactions

physically interacts with

1 reference

17 August 2016

1 reference

17 August 2016

1 reference

17 August 2016

1 reference

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

17 August 2016

legal status (medicine)

boxed warning

1 reference

reference URL

Australian pregnancy category C

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

pregnancy category

1 reference

imported from Wikimedia project

English Wikipedia

US pregnancy category C

1 reference

imported from Wikimedia project

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category C

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Ruxolitinib

2 December 2020

1 reference

https://www.novartis.com/about/products

subject has role

protein kinase inhibitors

1 reference

5 March 2018

Ruxolitinib

0 references

Identifiers

InChI

InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1

1 reference

Ruxolitinib (English)

20 November 2016

2 references

Ruxolitinib (English)

20 November 2016

ChEBI release 2020-09-01

CAS Registry Number

941678-49-5

2 references

ruxolitinib (English)

20 November 2016

https://commonchemistry.cas.org/detail?cas_rn=941678-49-5

9 April 2021

1 reference

Ruxolitinib (English)

20 November 2016

2 references

Ruxolitinib (English)

20 November 2016

Reaxys registry number

18703668

1 reference

ruxolitinib (English)

19 October 2016

ChEBI ID

66919

mapping relation type

2 references

RUXOLITINIB (English)

20 November 2016

International Chemical Identifier

InChI

InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1

1 reference

RUXOLITINIB (English)

20 November 2016

2 references

inferred from InChIKey

Hazardous Substances Data Bank

1 reference

1 reference

28 October 2019

RUXOLITINIB (English)

10 May 2021

2 references

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

DSSTOX compound identifier

0 references

0 references

1 reference

World Health Organisation international non-proprietary name numeric ID

Ruxolitinib (English)

publication date

17 November 2015

9287

1 reference

reference URL

https://mednet-communities.net/inn/db/ViewINN.aspx?i=9287

2 references

ruxolitinib (English)

20 November 2016

https://www.guidetopharmacology.org/coronavirus.jsp

22 April 2020

reference URL

0 references

1 reference

ruxolitinib (English)

20 November 2016

DrugBank ID

DB08877

1 reference

2 references

ruxolitinib (English)

20 November 2016

MedlinePlus drug identifier

a612006

route of administration

oral administration

0 references

a621053

route of administration

0 references

1 reference

ruxolitinib (English)

20 November 2016

0 references

1 reference

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

ruxolitinib (English)

19 October 2016

0 references

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

UK Parliament thesaurus ID

4U5J (English)

19 October 2016

1 reference

513523

subject named as

Ruxolitinib

0 references

UMLS CUI

C2931926

1 reference

ruxolitinib (English)