Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis (Q73315751)

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scientific article published on 01 December 2000

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English	Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis	scientific article published on 01 December 2000

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scholarly article

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Europe PubMed Central

PMC publication ID

6773037

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11124989%20AND%20SRC:MED&resulttype=core&format=json

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3 November 2019

title

Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis (English)

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Europe PubMed Central

PMC publication ID

6773037

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3 November 2019

main subject

amyotrophic lateral sclerosis

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S Vukosavic

series ordinal

1

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Europe PubMed Central

PMC publication ID

6773037

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3 November 2019

L Stefanis

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2

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Europe PubMed Central

PMC publication ID

6773037

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3 November 2019

V Jackson-Lewis

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3

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6773037

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3 November 2019

C Guégan

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4

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PMC publication ID

6773037

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3 November 2019

N Romero

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5

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Europe PubMed Central

PMC publication ID

6773037

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3 November 2019

C Chen

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6

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Europe PubMed Central

PMC publication ID

6773037

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11124989%20AND%20SRC:MED&resulttype=core&format=json

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M Dubois-Dauphin

series ordinal

7

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Europe PubMed Central

PMC publication ID

6773037

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3 November 2019

S Przedborski

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8

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Europe PubMed Central

PMC publication ID

6773037

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3 November 2019

publication date

1 December 2000

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Europe PubMed Central

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6773037

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11124989%20AND%20SRC:MED&resulttype=core&format=json

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3 November 2019

published in

Journal of Neuroscience

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PMC publication ID

6773037

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3 November 2019

volume

20

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Europe PubMed Central

PMC publication ID

6773037

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11124989%20AND%20SRC:MED&resulttype=core&format=json

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3 November 2019

issue

24

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Europe PubMed Central

PMC publication ID

6773037

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11124989%20AND%20SRC:MED&resulttype=core&format=json

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3 November 2019

page(s)

9119-9125

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Europe PubMed Central

PMC publication ID

6773037

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3 November 2019

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Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector.

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"Apoptotic" biochemical cascades in synaptic compartments: roles in adaptive plasticity and neurodegenerative disorders

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Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

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Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis

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12 December 2020

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Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

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12 December 2020

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Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

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Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

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Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells

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A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide

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Superoxide dismutase in familial amyotrophic lateral sclerosis: models for gain of function

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Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS)

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12 December 2020

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The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/11124989

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12 December 2020

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Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia.

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12 December 2020

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Differential requirement for caspase 9 in apoptotic pathways in vivo.

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12 December 2020

based on heuristic

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Activation of CPP-32 protease in hippocampal neurons following ischemia and epilepsy

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Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

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12 December 2020

based on heuristic

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Fractin immunostaining for the detection of apoptotic cells and apoptotic bodies in formalin-fixed and paraffin-embedded tissue

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12 December 2020

based on heuristic

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Neuronal cell death.

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PubMed

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12 December 2020

based on heuristic

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Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

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12 December 2020

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Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture

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Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of ICE slows ALS in mice

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/11124989

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in substantia nigra following developmental striatal excitotoxic injury

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/11124989

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspases: enemies within

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 gene family in the nervous system

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of apoptosis in mice with ALS

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: neurochemical correlates of selective vulnerability

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental cell death in dopaminergic neurons of the substantia nigra of mice.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/11124989

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1523/JNEUROSCI.20-24-09119.2000

1 reference

stated in

Europe PubMed Central

PMC publication ID

6773037

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11124989%20AND%20SRC:MED&resulttype=core&format=json

retrieved

3 November 2019

PMC publication ID

6773037

1 reference

stated in

Europe PubMed Central

PMC publication ID

6773037

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11124989%20AND%20SRC:MED&resulttype=core&format=json

retrieved

3 November 2019

PubMed publication ID

11124989

1 reference

stated in

Europe PubMed Central

PMC publication ID

6773037

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11124989%20AND%20SRC:MED&resulttype=core&format=json

retrieved

3 November 2019

 

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