Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme (Q77333661)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748545%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

review article

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title

Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748545%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

D A Burden

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4 December 2019

N Osheroff

series ordinal

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4 December 2019

language of work or name

English

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publication date

1 October 1998

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748545%20AND%20SRC:MED&resulttype=core&format=json

Biochimica et Biophysica Acta

4 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748545%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

volume

1400

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4 December 2019

issue

1-3

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4 December 2019

page(s)

139-154

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Biochemical basis for the interactions of type I and type II topoisomerases with DNA.

4 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Catalytic function of DNA topoisomerase II.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Type II DNA topoisomerases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

1 reference

7 January 2021

Structure and function of type II DNA topoisomerases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

ATP-dependent DNA topoisonmerase from D. melanogaster reversibly catenates duplex DNA rings

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Proteolysis patterns of epitopically labeled yeast DNA topoisomerase II suggest an allosteric transition in the enzyme induced by ATP binding

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

DNA topoisomerase-trapping antitumour drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

When good enzymes go bad: conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

DNA topoisomerases: essential enzymes and lethal targets

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Topoisomerase inhibitors. A review of their therapeutic potential in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Purification and characterization of an altered topoisomerase II from a drug-resistant Chinese hamster ovary cell line.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Purification and characterization of type II DNA topoisomerase from mouse FM3A cells: phosphorylation of topoisomerase II and modification of its activity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

A functional 125-kDa core polypeptide of fission yeast DNA topoisomerase II

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Tandem regions of yeast DNA topoisomerase II share homology with different subunits of bacterial gyrase.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Structure of the Drosophila DNA topoisomerase II gene. Nucleotide sequence and homology among topoisomerases II.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Functional dissection of the phosphorylated termini of fission yeast DNA topoisomerase II

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

The C-terminal domain of Saccharomyces cerevisiae DNA topoisomerase II.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Yeast DNA topoisomerase II is encoded by a single-copy, essential gene

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Novel HeLa topoisomerase II is the II beta isoform: complete coding sequence and homology with other type II topoisomerases.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Phosphorylation of the alpha- and beta-isoforms of DNA topoisomerase II is qualitatively different in interphase and mitosis in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Differential expressions of the topoisomerase II alpha and II beta mRNAs in developing rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Complementation of temperature-sensitive topoisomerase II mutations in Saccharomyces cerevisiae by a human TOP2 beta construct allows the study of topoisomerase II beta inhibitors in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Growth state and cell cycle dependent phosphorylation of DNA topoisomerase II in Swiss 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Cell-cycle-dependent phosphorylation and activity of Chinese-hamster ovary topoisomerase II.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Topoisomerase II: A specific marker for cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Role of the divalent cation in topoisomerase II mediated reactions.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Sequence dependence of Drosophila topoisomerase II in plasmid relaxation and DNA binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Characterization of the interaction between topoisomerase II and DNA by transcriptional footprinting

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Drosophila topoisomerase II-DNA interactions are affected by DNA structure

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Human 170 kDa and 180 kDa topoisomerases II bind preferentially to curved and left-handed linear DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Phosphorylation of the C-terminal domain of yeast topoisomerase II by casein kinase II affects DNA-protein interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Strand specificity of the topoisomerase II mediated double-stranded DNA cleavage reaction.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Drosophila topoisomerase II double-strand DNA cleavage: analysis of DNA sequence homology at the cleavage site

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

A consensus sequence for cleavage by vertebrate DNA topoisomerase II.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Dysfunction of chromosomal loop attachment sites: illegitimate recombination linked to matrix association regions and topoisomerase II.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Eukaryotic topoisomerase II preferentially cleaves alternating purine-pyrimidine repeats

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Z-DNA binding and inhibition by GTP of Drosophila topoisomerase II.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Eukaryotic topoisomerase II cleavage of parallel stranded DNA tetraplexes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Crystal structure of an N-terminal fragment of the DNA gyrase B protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Nucleotide binding to the 43-kilodalton N-terminal fragment of the DNA gyrase B protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Structure and mechanism of DNA topoisomerase II

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Recent developments in DNA topoisomerase II structure and mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Purification and characterization of Xenopus laevis topoisomerase II.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Purification and characterization of DNA topoisomerase II from calf thymus associated with polypeptides of 175 and 150 kDa.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

DNA transport by a type II topoisomerase: direct evidence for a two-gate mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Intradimerically tethered DNA topoisomerase II is catalytically active in DNA transport

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

DNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Protein kinase C modulates the catalytic activity of topoisomerase II by enhancing the rate of ATP hydrolysis: evidence for a common mechanism of regulation by phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

DNA filter elution: a window on DNA damage in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Topoisomerase II enzymes and mutagenicity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

DNA topoisomerase-targeting antitumor drugs can be studied in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

The production of chromosomal alterations in human lymphocytes by drugs known to interfere with the activity of DNA topoisomerase II. I. m-AMSA.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

DNA topoisomerase II is required for formation of mitotic chromosomes in Chinese hamster ovary cells: studies using the inhibitor 4'-demethylepipodophyllotoxin 9-(4,6-O-thenylidene-beta-D-glucopyranoside).

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Small deletion and insertion mutations induced by the topoisomerase II inhibitor teniposide in CHO cells and comparison with sites of drug-stimulated DNA cleavage in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Apoptosis induced by DNA topoisomerase I and II inhibitors in human leukemic HL-60 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Mechanisms of resistance to topoisomerase inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Etoposide: current status and future perspectives in the management of malignant neoplasms

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Eating to beat breast cancer: potential role for soy supplements

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

The molecular basis of quinolone action

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Fluoroquinolone antimicrobial agents

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Formation of topoisomerase II alpha complexes with nascent DNA is related to VM-26-induced cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Drug resistance associated with altered DNA topoisomerase II.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

DNA topoisomerase II mutations and resistance to anti-tumor drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Antitopoisomerase drug action and resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Further characterization of an amsacrine-resistant line of HL-60 human leukemia cells and its topoisomerase II. Effects of ATP concentration, anion concentration, and the three-dimensional structure of the DNA target.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

The interaction between nuclear topoisomerase II activity from human leukemia cells, exogenous DNA, and 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) or 4-(4,6-O-ethylidene-beta-D-glucopyranoside) (VP-16) indicates the sensitivity of the c

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. Uncoupling the DNA binding, cleavage and religation events

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Topoisomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Azatoxin Is a Mechanistic Hybrid of the Topoisomerase II-Targeted Anticancer Drugs Etoposide and Ellipticine

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Spontaneous DNA damage stimulates topoisomerase II-mediated DNA cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Apurinic sites are position-specific topoisomerase II poisons.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Mechanism of action of quinolones against Escherichia coli DNA gyrase

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

Increased drug affinity as the mechanistic basis for drug hypersensitivity of a mutant type II topoisomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2898%2900132-8

7 January 2021

10.1016/S0167-4781(98)00132-8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748545%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

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