Intact aggrecan and fragments generated by both aggrecanse and metalloproteinase-like activities are present in the developing and adult rat spinal cord and their relative abundance is altered by injury (Q74096691)

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scientific article published on 01 July 2001

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English	Intact aggrecan and fragments generated by both aggrecanse and metalloproteinase-like activities are present in the developing and adult rat spinal cord and their relative abundance is altered by injury	scientific article published on 01 July 2001

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scholarly article

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8 November 2019

Intact aggrecan and fragments generated by both aggrecanse and metalloproteinase-like activities are present in the developing and adult rat spinal cord and their relative abundance is altered by injury (English)

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8 November 2019

author name string

M L Lemons

1

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8 November 2019

J D Sandy

2

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8 November 2019

D K Anderson

3

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8 November 2019

D R Howland

4

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8 November 2019

publication date

1 July 2001

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8 November 2019

Journal of Neuroscience

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8 November 2019

21

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8 November 2019

13

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8 November 2019

4772-4781

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8 November 2019

Domain organization, genomic structure, evolution, and regulation of expression of the aggrecan gene family

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

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Boundaries during normal and abnormal brain development: In vivo and in vitro studies of glia and glycoconjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

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Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regrowth of motor axons following spinal cord lesions: distribution of laminin and collagen in the CNS scar tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondroitin Sulfate and Chondroitin/Keratan Sulfate Proteoglycans of Nervous Tissue: Developmental Changes of Neurocan and Phosphacan

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinases in brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcripts for secreted and GPI-anchored brevican are differentially distributed in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peanut agglutinin and chondroitin-6-sulfate are molecular markers for tissues that act as barriers to axon advance in the avian embryo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycoconjugates mark a transient barrier to neural crest migration in the chicken embryo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurite outgrowth on a step gradient of chondroitin sulfate proteoglycan (CS-PG).

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spatial and temporal changes in the distribution of proteoglycans during avian neural crest development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of developmentally regulated chondroitin sulfate and chondroitin/keratan sulfate proteoglycans of brain identified with monoclonal antibodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth cone behavior in the presence of soluble chondroitin sulfate proteoglycan (CSPG), compared to behavior on CSPG bound to laminin or fibronectin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Large diameter primary afferent input is required for expression of the Cat-301 proteoglycan on the surface of motor neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The high molecular weight Cat-301 chondroitin sulfate proteoglycan from brain is related to the large aggregating proteoglycan from cartilage, aggrecan

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brevican: a major proteoglycan in adult brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondroitin sulfate proteoglycans in the developing central nervous system. I. cellular sites of synthesis of neurocan and phosphacan

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated macrophages and the blood-brain barrier: inflammation after CNS injury leads to increases in putative inhibitory molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Versican is selectively expressed in embryonic tissues that act as barriers to neural crest cell migration and axon outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two types of brain chondroitin sulfate proteoglycan: their distribution and possible functions in the rat embryo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggrecan degradation in human intervertebral disc and articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cDNA cloning and the identification of an aggrecanase-like cleavage site in rat brevican

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of cartilage aggrecan by collagenase-3 (MMP-13)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycosaminoglycan sulfation in human osteoarthritis. Disease-related alterations at the non-reducing termini of chondroitin and dermatan sulfate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the catabolism of aggrecan in cartilage explants by quantitation of peptides from the three globular domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lecticans: organizers of the brain extracellular matrix

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping of a defined neurocan binding site to distinct domains of tenascin-C

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggrecan degradation in osteoarthritis and rheumatoid arthritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondroitin Sulfate as a Regulator of Neuronal Patterning in the Retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of proteoglycans

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S103L reactive chondroitin sulfate proteoglycan (aggrecan) mRNA expressed in developing chick brain and cartilage is encoded by a single gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing i

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondroitin sulfate proteoglycan and tenascin in the wounded adult mouse neostriatum in vitro: dopamine neuron attachment and process outgrowth.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathways of aggrecan processing in joint tissues. Implications for disease mechanism and monitoring

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regeneration of adult axons in white matter tracts of the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased production of gelatinase B (matrix metalloproteinase-9) and interleukin-6 by activated rat microglia in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The brain chondroitin sulfate proteoglycan brevican associates with astrocytes ensheathing cerebellar glomeruli and inhibits neurite outgrowth from granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the existence of a cartilage-like proteoglycan and link proteins in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of neural crest cells from the region surrounding implanted notochords in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent inhibition of neural crest migration by the notochord correlates with alterations in the S103L chondroitin sulfate proteoglycan

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of keratan sulphate and chondroitin sulphate in wild type and white mutant axolotl embryos during neural crest cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-beta receptors and binding proteoglycans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of a chondroitin sulfate proteoglycan in the avoidance of chick epidermis by dorsal root ganglia fibers: a study using beta-D-xyloside

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functions of brain chondroitin sulfate proteoglycans during developments: interactions with adhesion molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondroitin sulfate proteoglycan immunoreactivity increases following spinal cord injury and transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondroitin sulfate proteoglycans in the developing central nervous system. II. Immunocytochemical localization of neurocan and phosphacan

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of neurite growth by the NG2 chondroitin sulfate proteoglycan

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental expression of S103L cross-reacting proteoglycans in embryonic chick.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of two growth factor families to separate domains of the proteoglycan betaglycan

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heparan sulfate: a piece of information

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of an activity-dependent, neuronal surface proteoglycan identified with monoclonal antibody Cat-301.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondroitin sulfate proteoglycan expression pattern in hippocampal development: potential regulation of axon tract formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A chondroitin sulfate proteoglycan may influence the direction of retinal ganglion cell outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11425904

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.21-13-04772.2001

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11425904%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11425904%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11425904%20AND%20SRC:MED&resulttype=core&format=json

8 November 2019

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