Immunopathology of multiple sclerosis (Q63285399)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26250739%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

review article

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title

Immunopathology of multiple sclerosis (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26250739%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

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21 February 2020

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21 February 2020

Lars Fugger

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21 February 2020

publication date

7 August 2015

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26250739%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Immunology

21 February 2020

published in

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21 February 2020

volume

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21 February 2020

issue

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21 February 2020

page(s)

545-558

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21 February 2020

1 reference

Cervical cord lesion load is associated with disability independently from atrophy in MS.

31 March 2020

1 reference

The relation between inflammation and neurodegeneration in multiple sclerosis brains.

31 March 2020

1 reference

Therapies for multiple sclerosis: translational achievements and outstanding needs

31 March 2020

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Treatment of progressive multiple sclerosis: what works, what does not, and what is needed

31 March 2020

1 reference

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis.

31 March 2020

1 reference

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.

31 March 2020

1 reference

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.

31 March 2020

1 reference

Pathology of demyelinating diseases

31 March 2020

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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

31 March 2020

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Variation in the human immune system is largely driven by non-heritable influences

31 March 2020

1 reference

Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses

31 March 2020

1 reference

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides

31 March 2020

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Antiviral immune responses: triggers of or triggered by autoimmunity?

31 March 2020

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A virus-induced molecular mimicry model of multiple sclerosis

31 March 2020

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Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs.

31 March 2020

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The anatomical and cellular basis of immune surveillance in the central nervous system.

31 March 2020

1 reference

Structural and functional features of central nervous system lymphatic vessels

31 March 2020

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Innate immune activation in neurodegenerative disease

31 March 2020

1 reference

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

31 March 2020

1 reference

Disease networks. Uncovering disease-disease relationships through the incomplete interactome

31 March 2020

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Selecting causal genes from genome-wide association studies via functionally coherent subnetworks

31 March 2020

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Genetic and epigenetic fine mapping of causal autoimmune disease variants

31 March 2020

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Integrative analysis of 111 reference human epigenomes

31 March 2020

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Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

31 March 2020

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Intersection of population variation and autoimmunity genetics in human T cell activation

31 March 2020

1 reference

The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis

31 March 2020

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Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

31 March 2020

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Functional epistasis on a common MHC haplotype associated with multiple sclerosis

31 March 2020

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Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells

31 March 2020

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Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

31 March 2020

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Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis

31 March 2020

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Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity

31 March 2020

1 reference

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

31 March 2020

1 reference

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

31 March 2020

1 reference

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

31 March 2020

1 reference

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

31 March 2020

1 reference

Time course and localization patterns of interleukin-1beta messenger RNA expression in brain and pituitary after peripheral administration of lipopolysaccharide

31 March 2020

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Cytokine signals propagate through the brain

31 March 2020

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From inflammation to sickness and depression: when the immune system subjugates the brain

31 March 2020

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Shift work at young age is associated with increased risk for multiple sclerosis

31 March 2020

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A case-control study of multiple sclerosis

31 March 2020

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High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8+ T cells

31 March 2020

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Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells.

31 March 2020

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Thymic involution and proliferative T-cell responses in multiple sclerosis.

31 March 2020

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Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis

31 March 2020

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The virome in mammalian physiology and disease

31 March 2020

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Human gut microbiome viewed across age and geography

31 March 2020

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Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.

31 March 2020

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Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis.

31 March 2020

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T-cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls

31 March 2020

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Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis.

31 March 2020

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MHC class I-restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8⁺ T cells

31 March 2020

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Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides

31 March 2020

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Antigen-specific tolerance by autologous myelin peptide-coupled cells: a phase 1 trial in multiple sclerosis

31 March 2020

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Interferon beta induces T-helper 2 immune deviation in MS

31 March 2020

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Treatment of multiple sclerosis with copolymer-1 (Copaxone): implicating mechanisms of Th1 to Th2/Th3 immune-deviation

31 March 2020

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Cytokine Secretion Pattern in Treatment of Lymphocytes of Multiple Sclerosis Patients with Fumaric Acid Esters

31 March 2020

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IL17 and IFNgamma production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis

31 March 2020

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Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis

31 March 2020

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Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis.

31 March 2020

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Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

31 March 2020

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Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

31 March 2020

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Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.

31 March 2020

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RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.

31 March 2020

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IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells.

31 March 2020

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Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells

31 March 2020

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CD8⁺ MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL-18 serum levels in multiple sclerosis

31 March 2020

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Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis

31 March 2020

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Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

31 March 2020

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Lymphoid organ development: from ontogeny to neogenesis

31 March 2020

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Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis

31 March 2020

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Investigation of the KIR4.1 potassium channel as a putative antigen in patients with multiple sclerosis: a comparative study.

31 March 2020

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Autoimmune encephalopathies

31 March 2020

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Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis.

31 March 2020

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B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

31 March 2020

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B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

31 March 2020

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Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

31 March 2020

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B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells

31 March 2020

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Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression.

31 March 2020

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IL-10 suppressor activity andex vivo Tr1 cell function are impaired in multiple sclerosis

31 March 2020

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Intracerebral human regulatory T cells: analysis of CD4+ CD25+ FOXP3+ T cells in brain lesions and cerebrospinal fluid of multiple sclerosis patients.

31 March 2020

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Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

31 March 2020

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BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.

31 March 2020

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Super-enhancers delineate disease-associated regulatory nodes in T cells

31 March 2020

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

31 March 2020

1 reference

Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

31 March 2020

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Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients.

31 March 2020

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CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis

31 March 2020

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Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

31 March 2020

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In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling

31 March 2020

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Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6.

31 March 2020

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Analysis of regulatory CD8 T cells in Qa-1-deficient mice

31 March 2020

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HLA-E restricted CD8+ T cell subsets are phenotypically altered in multiple sclerosis patients.

31 March 2020

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Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis

31 March 2020

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Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis

31 March 2020

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Hematopoietic mobilization: Potential biomarker of response to natalizumab in multiple sclerosis.

31 March 2020

1 reference

IFN-β treatment requires B cells for efficacy in neuroautoimmunity.

31 March 2020

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IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

31 March 2020

1 reference

31 March 2020

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Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome

31 March 2020

1 reference

A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology

31 March 2020

1 reference

Brain atrophy in clinically early relapsing-remitting multiple sclerosis.

31 March 2020

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Differential roles of microglia and monocytes in the inflamed central nervous system

31 March 2020

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Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain

31 March 2020

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Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death

31 March 2020

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A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

31 March 2020

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Homeostasis, inflammation, and disease susceptibility

31 March 2020

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Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system

31 March 2020

1 reference

Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function

31 March 2020

1 reference

Neuromyelitis optica and asian phenotype of multiple sclerosis

31 March 2020

1 reference

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

31 March 2020

1 reference

Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates

31 March 2020

1 reference

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

31 March 2020

1 reference

Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

31 March 2020

1 reference

From classic to spontaneous and humanized models of multiple sclerosis: impact on understanding pathogenesis and drug development.

31 March 2020

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Clonally expanded mitochondrial DNA deletions within the choroid plexus in multiple sclerosis

31 March 2020

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Oxidative damage in multiple sclerosis lesions

31 March 2020

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Differential diagnosis of Mendelian and mitochondrial disorders in patients with suspected multiple sclerosis

31 March 2020

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Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger

31 March 2020

1 reference

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26250739

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI3871

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26250739%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

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