CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes (Q63241956)

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14 December 2019

title

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes (English)

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14 December 2019

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14 December 2019

Namrata Bahadur

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14 December 2019

Elaine Mutch

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14 December 2019

Dorothy Steimel-Crespi

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14 December 2019

Stuart A Dunn

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14 December 2019

Ron Gilissen

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14 December 2019

Jos Van Houdt

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14 December 2019

Jan Hendrickx

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14 December 2019

Geert Mannens

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14 December 2019

Hilde Bohets

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14 December 2019

Faith M Williams

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14 December 2019

Martin Armstrong

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Charles L Crespi

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14 December 2019

Julian B S Leathart

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language of work or name

English

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publication date

1 December 2002

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14 December 2019

published in

Biochemical Pharmacology

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volume

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issue

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14 December 2019

page(s)

1579-1589

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Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

14 December 2019

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Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation

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Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans

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Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone

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Clinical pharmacokinetics of cerivastatin

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Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate

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Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform

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Antisense oligonucleotides against cytochrome P450 2C8 attenuate EDHF-mediated Ca(2+) changes and dilation in isolated resistance arteries.

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Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries.

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The role of metabolism in determining susceptibility to parathion toxicity in man.

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Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

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Analysis of selective regions in the active sites of human cytochromes P450, 2C8, 2C9, 2C18, and 2C19 homology models using GRID/CPCA.

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cDNA and amino acid sequences of two members of the human P450IIC gene subfamily

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Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase

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Cloning, experession and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family

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Sequence of a human liver cytochrome P-450 cDNA clone

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Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

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Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism

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Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

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Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans

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A general method for isolation of high molecular weight DNA from eukaryotes

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Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs

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Fast and sensitive silver staining of DNA in polyacrylamide gels

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Induction potential of antifungals containing an imidazole or triazole moiety. Miconazole and ketoconazole, but not itraconazole are able to induce hepatic drug metabolizing enzymes of male rats at high doses

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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10.1016/S0006-2952(02)01354-0

7 January 2021

Identifiers

DOI

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14 December 2019

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