Drug Repurposing Approaches for the Treatment of Influenza Viral Infection: Reviving Old Drugs to Fight Against a Long-Lived Enemy (Q63246314)

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1 May 2020

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27 October 2020

23 October 2022

Drug Repurposing Approaches for the Treatment of Influenza Viral Infection: Reviving Old Drugs to Fight Against a Long-Lived Enemy (English)

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1 May 2020

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1 May 2020

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1 May 2020

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Manuel Rosa-Calatrava

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Manuel Rosa-Calatrava

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language of work or name

English

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publication date

19 March 2019

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27 October 2020

23 October 2022

Frontiers in Immunology

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1 May 2020

27 October 2020

23 October 2022

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page(s)

531

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Creative Commons Attribution 4.0 International

1 May 2020

2 references

27 October 2020

Treatment of influenza. The therapeutic efficacy of rimantadine HC1 in a naturally occurring influenza A2 outbreak

23 October 2022

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A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment

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Association between use of statins and mortality among patients hospitalized with laboratory-confirmed influenza virus infections: a multistate study

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Community Transmission of Oseltamivir-Resistant A(H1N1)pdm09 Influenza

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Molecular dynamics studies of the nucleoprotein of influenza A virus: role of the protein flexibility in RNA binding

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Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing.

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Single-dose inhaled laninamivir: registered in Japan and its potential role in control of influenza epidemics

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The effect of rosuvastatin in a murine model of influenza A infection

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Oseltamivir-zanamivir bitherapy compared to oseltamivir monotherapy in the treatment of pandemic 2009 influenza A(H1N1) virus infections.

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Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection

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Polypharmacology: drug discovery for the future

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Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance

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Shifting from the single to the multitarget paradigm in drug discovery

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Effect of statin treatments on highly pathogenic avian influenza H5N1, seasonal and H1N1pdm09 virus infections in BALB/c mice

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Computational drug repositioning: from data to therapeutics

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12 December 2020

Simvastatin and oseltamivir combination therapy does not improve the effectiveness of oseltamivir alone following highly pathogenic avian H5N1 influenza virus infection in mice

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12 December 2020

Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus

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12 December 2020

The rise, fall and subsequent triumph of thalidomide: lessons learned in drug development

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12 December 2020

How academic labs can approach the drug discovery process as a way to synergize with big pharma

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12 December 2020

Treating influenza with statins and other immunomodulatory agents.

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12 December 2020

Open-source approaches for the repurposing of existing or failed candidate drugs: learning from and applying the lessons across diseases

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12 December 2020

Influenza treatment and prophylaxis with neuraminidase inhibitors: a review

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12 December 2020

Drug repositioning: playing dirty to kill pain.

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12 December 2020

Inhibition of the inflammatory cytokine tumor necrosis factor-alpha with etanercept provides protection against lethal H1N1 influenza infection in mice

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12 December 2020

Oseltamivir-zanamivir combination therapy is not superior to zanamivir monotherapy in mice infected with influenza A(H3N2) and A(H1N1)pdm09 viruses.

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12 December 2020

Will omics help to cure the flu?

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12 December 2020

Neuraminidase inhibitors for preventing and treating influenza in adults and children

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Systematic drug repurposing through text mining

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12 December 2020

Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial

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12 December 2020

Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks

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12 December 2020

Nitazoxanide: a first-in-class broad-spectrum antiviral agent

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Generation and characterization of influenza A viruses with altered polymerase fidelity

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12 December 2020

Synergistic effect of nitazoxanide with neuraminidase inhibitors against influenza A viruses in vitro

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Influenza virus-host interactome screen as a platform for antiviral drug development

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12 December 2020

Mechanisms of action and efficacy of statins against influenza.

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12 December 2020

Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials

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Neuraminidase inhibitors: who, when, where?

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Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2013-2014.

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The development and manufacture of influenza vaccines

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Repurposing Kinase Inhibitors as Antiviral Agents to Control Influenza A Virus Replication

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12 December 2020

Identification of drug candidates and repurposing opportunities through compound-target interaction networks

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12 December 2020

Drug Repurposing Identifies Inhibitors of Oseltamivir-Resistant Influenza Viruses

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Pharmacodynamics, Pharmacokinetics, and Antiviral Activity of BAY 81-8781, a Novel NF-κB Inhibiting Anti-influenza Drug

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Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics

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Repurposing drugs for use against Zika virus infection

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Hyphenated 3D-QSAR statistical model-drug repurposing analysis for the identification of potent neuraminidase inhibitor.

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Innovation and trends in the development and approval of antiviral medicines: 1987-2017 and beyond

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Drug Repurposing for Viral Infectious Diseases: How Far Are We?

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12 December 2020

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.

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12 December 2020

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12 December 2020

Clinical Regimens of Favipiravir Inhibit Zika Virus Replication in the Hollow-Fiber Infection Model

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12 December 2020

The clinically approved MEK inhibitor Trametinib efficiently blocks influenza A virus propagation and cytokine expression

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12 December 2020

From Naproxen Repurposing to Naproxen Analogues and Their Antiviral Activity against Influenza A Virus

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12 December 2020

Network-Based Drug Discovery: Coupling Network Pharmacology with Phenotypic Screening for Neuronal Excitability

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12 December 2020

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents

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12 December 2020

Treating Influenza Infection, From Now and Into the Future

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12 December 2020

Drug repurposing: progress, challenges and recommendations

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12 December 2020

In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit

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12 December 2020

Repurposing of Drugs as Novel Influenza Inhibitors From Clinical Gene Expression Infection Signatures

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12 December 2020

Identifiers

DOI

10.3389/FIMMU.2019.00531

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30941148%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30941148%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

PubMed publication ID

30941148

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30941148%20AND%20SRC:MED&resulttype=core&format=json