A seven-step plan for becoming a moderately rich and famous biochemist (Q61797397)

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scientific article published in Journal of Biological Chemistry

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English	A seven-step plan for becoming a moderately rich and famous biochemist	scientific article published in Journal of Biological Chemistry

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scholarly article

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title

A seven-step plan for becoming a moderately rich and famous biochemist (English)

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main subject

celecoxib

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icosanoid

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naproxen

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omega-3 fatty acid

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author name string

William L Smith

series ordinal

1

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language of work or name

English

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publication date

8 February 2019

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number of pages

15

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based on heuristic

inferred from page(s)

published in

Journal of Biological Chemistry

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volume

294

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issue

6

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page(s)

1779-1793

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cites work

Immunohistochemical localization of the prostaglandin-forming cyclooxygenase in renal cortex

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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The Prostaglandin Forming Cyclooxygenase of Ovine Uterus: Relationship to Luteal Function

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

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Acetylation of prostaglandin synthase by aspirin

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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inferred from PubMed ID database lookup

Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Essential histidines of prostaglandin endoperoxide synthase. His-309 is involved in heme binding

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular gland

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Oxygenation of Unsaturated Fatty Acids by Soybean Lipoxygenase

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Stimulation and blockade of prostaglandin biosynthesis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Aspirin selectively inhibits prostaglandin production in human platelets

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Indomethacin and aspirin abolish prostaglandin release from the spleen

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Cofactor Requirements of the Enzyme Synthesizing Prostaglandin in Bovine Seminal Vesicles

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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On the Specificity of the Oxygenation of Unsaturated Fatty Acids Catalyzed by Soybean Lipoxidase

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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On the mechanism of the biosynthesis of prostaglandins E-1 and F-1-alpha

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygenation of Unsaturated Fatty Acids by the Vesicular Gland of Sheep

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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inferred from PubMed ID database lookup

Kinin-induced prostaglandin synthesis by renal papillary collecting tubule cells in culture

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Isolation and covalent structure of the aspirin-modified, active-site region of prostaglandin synthetase

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Prostaglandin H synthase. Stoichiometry of heme cofactor

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Apical-basolateral membrane asymmetry in canine cortical collecting tubule cells. Bradykinin, arginine vasopressin, prostaglandin E2 interrelationships

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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inferred from PubMed ID database lookup

Subcellular localization of prostaglandin-forming cyclooxygenase in Swiss mouse 3T3 fibroblasts by electron microscopic immunocytochemistry.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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inferred from PubMed ID database lookup

Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2.

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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inferred from PubMed ID database lookup

Purification and characterization of recombinant human cyclooxygenase-2

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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inferred from PubMed ID database lookup

The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Characterization of a tyrosyl radical in prostaglandin endoperoxide synthase-2

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Characterization of the tyrosyl radicals in ovine prostaglandin H synthase-1 by isotope replacement and site-directed mutagenesis.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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inferred from PubMed ID database lookup

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostanoid receptors of murine NIH 3T3 and RAW 264.7 cells. Structure and expression of the murine prostaglandin EP4 receptor gene

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The membrane binding domains of prostaglandin endoperoxide H synthases 1 and 2. Peptide mapping and mutational analysis

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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inferred from PubMed ID database lookup

Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin H synthase-2 inhibitors interfere with prostaglandin H synthase-1 inhibition by nonsteroidal anti-inflammatory drugs

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

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Metabolism of glycerolipides; a comparison of lecithin and triglyceride synthesis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Crystalline D-gluconate 6-phosphate dehydrogenase

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Molecular basis of the time-dependent inhibition of cyclooxygenases by indomethacin

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An intronic enhancer regulates cyclooxygenase-1 gene expression

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Partnering between monomers of cyclooxygenase-2 homodimers

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Cyclooxygenase-2 gene transcription in a macrophage model of inflammation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Two distinct pathways for cyclooxygenase-2 protein degradation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Prostaglandin H synthase: resolved and unresolved mechanistic issues

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Two pathways for cyclooxygenase-2 protein degradation in vivo

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Asymmetric acetylation of the cyclooxygenase-2 homodimer by aspirin and its effects on the oxygenation of arachidonic, eicosapentaenoic, and docosahexaenoic acids

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Human Cyclooxygenase-2 Is a Sequence Homodimer That Functions as a Conformational Heterodimer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Human cyclooxygenase-1 activity and its responses to COX inhibitors are allosterically regulated by nonsubstrate fatty acids

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Major urinary metabolites of 6-keto-prostaglandin F2α in mice

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

based on heuristic

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Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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A cyclooxygenase-2-dependent prostaglandin E2 biosynthetic system in the Golgi apparatus

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Different Fatty Acids Compete with Arachidonic Acid for Binding to the Allosteric or Catalytic Subunits of Cyclooxygenases to Regulate Prostanoid Synthesis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

based on heuristic

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Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Coxibs, Traditional NSAIDs, and Cardiovascular Safety Post-PRECISION: What We Thought We Knew Then and What We Think We Know Now.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

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Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30737317

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12 December 2020

based on heuristic

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Interactions of fatty acids, nonsteroidal anti-inflammatory drugs, and coxibs with the catalytic and allosteric subunits of cyclooxygenases-1 and -2

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30737317

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.X118.006184

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PMC publication ID

6369280

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PubMed publication ID

30737317

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