mitogen-activated protein kinase 8 (Q6714411)

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mammalian protein found in Homo sapiens
  • JUN N-terminal kinase
  • SAPK1c
  • stress-activated protein kinase 1c
  • Stress-activated protein kinase JNK1
  • mitogen-activated protein kinase 8
  • c-Jun N-terminal kinase 1
  • MAP kinase 8
  • mitogen-activated protein kinase 8 isoform JNK1 beta2
  • stress-activated protein kinase 1
  • mitogen-activated protein kinase 8 isoform JNK1 alpha1
  • MAPK8
  • JNK-46
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Language Label Description Also known as
English
mitogen-activated protein kinase 8
mammalian protein found in Homo sapiens
  • JUN N-terminal kinase
  • SAPK1c
  • stress-activated protein kinase 1c
  • Stress-activated protein kinase JNK1
  • mitogen-activated protein kinase 8
  • c-Jun N-terminal kinase 1
  • MAP kinase 8
  • mitogen-activated protein kinase 8 isoform JNK1 beta2
  • stress-activated protein kinase 1
  • mitogen-activated protein kinase 8 isoform JNK1 alpha1
  • MAPK8
  • JNK-46

Statements

molecular function
protein serine/threonine kinase activity
determination method or standard
IDA
IEA
5 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P45983
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IEA
retrieved
8 April 2019
stated in
Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells
GOA
curator
UniProt
UniProt protein ID
P45983
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IDA
retrieved
8 April 2019
stated in
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity
GOA
curator
UniProt
UniProt protein ID
P45983
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IDA
retrieved
8 April 2019
stated in
JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IDA
retrieved
8 April 2019
stated in
The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IDA
protein binding
determination method or standard
IPI
20 references
retrieved
8 April 2019
stated in
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
GOA
curator
UniProt
UniProt protein ID
P45983
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death
GOA
curator
UniProt
UniProt protein ID
P45983
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity
GOA
curator
UniProt
UniProt protein ID
P45983
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun
GOA
curator
UniProt
UniProt protein ID
P45983
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
The JIP group of mitogen-activated protein kinase scaffold proteins
GOA
curator
UniProt
UniProt protein ID
P45983
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tyrosine kinase Syk regulates TPL2 activation signals
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
A selective small-molecule inhibitor of c-Jun N-terminal kinase 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
retrieved
8 April 2019
stated in
Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P45983
determination method or standard
IPI
cell component
biological process
Gene Atlas image
PBB GE MAPK8 210671 x at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D048055
subject named as
Mitogen-Activated Protein Kinase 8
0 references
RefSeq protein ID
PDB structure ID
 
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