Ultrastructural alterations in the retinal pigment epithelium and photoreceptors of a Stargardt patient and three Stargardt mouse models: indication for the central role of RPE melanin in oxidative stress. (Q64988602)

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scientific article published on 19 July 2018

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English	Ultrastructural alterations in the retinal pigment epithelium and photoreceptors of a Stargardt patient and three Stargardt mouse models: indication for the central role of RPE melanin in oxidative stress.	scientific article published on 19 July 2018

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13 April 2020

Ultrastructural alterations in the retinal pigment epithelium and photoreceptors of a Stargardt patient and three Stargardt mouse models: indication for the central role of RPE melanin in oxidative stress (English)

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13 April 2020

Tatjana Taubitz

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13 April 2020

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Alexander V Tschulakow

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13 April 2020

Marina Tikhonovich

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13 April 2020

Barbara Illing

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13 April 2020

Yuan Fang

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13 April 2020

Antje Biesemeier

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13 April 2020

Sylvie Julien-Schraermeyer

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13 April 2020

Ulrich Schraermeyer

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19 July 2018

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13 April 2020

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13 April 2020

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13 April 2020

e5215

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13 April 2020

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Creative Commons Attribution 4.0 International

19 July 2018

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Immunocytochemical localization of a large intrinsic membrane protein to the incisures and margins of frog rod outer segment disks.

1 reference

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Repigmentation of human retinal pigment epithelial cells in vitro

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Melanosomes are specialized members of the lysosomal lineage of organelles.

1 reference

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Blue light-induced reactivity of retinal age pigment. In vitro generation of oxygen-reactive species

1 reference

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Lysosomal hydrolases are present in melanosomes and are elevated in melanizing cells

1 reference

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12 December 2020

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A newly discovered pathway of melanin formation in cultured retinal pigment epithelium of cattle

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Histopathology and immunocytochemistry of the neurosensory retina in fundus flavimaculatus.

1 reference

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Evaluation of oxidative processes in human pigment epithelial cells associated with retinal outer segment phagocytosis

1 reference

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12 December 2020

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Superoxide inhibits proliferation and phagocytic internalization of photoreceptor outer segments by bovine retinal pigment epithelium in vitro

1 reference

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Does melanin turnover occur in the eyes of adult vertebrates?

1 reference

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Role of melanin as a scavenger of active oxygen species

1 reference

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12 December 2020

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A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy

1 reference

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12 December 2020

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Morphological, physiological, and biochemical changes in rhodopsin knockout mice

1 reference

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Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

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Melanin granules of retinal pigment epithelium are connected with the lysosomal degradation pathway

1 reference

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12 December 2020

based on heuristic

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Retinal pigment epithelium pigment granules stimulate the photo-oxidation of unsaturated fatty acids

1 reference

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Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

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Current understanding on the role of retinal pigment epithelium and its pigmentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

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A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

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Ultrastructural changes associated with accumulation of inclusion bodies in rat retinal pigment epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

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Lipofuscin-formation in cultured retinal pigment epithelial cells is related to their melanin content

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

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Regulation of the catalytic activity of preexisting tyrosinase in black and Caucasian human melanocyte cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

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based on heuristic

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The cGMP-gated channel and related glutamic acid-rich proteins interact with peripherin-2 at the rim region of rod photoreceptor disc membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

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Cyclic nucleotide-gated ion channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of intact lysosomes from human RPE cells and effects of A2-E on the integrity of the lysosomal and other cellular membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

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inferred from PubMed ID database lookup

Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

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A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA Is a Target of the Photodynamic Effects Elicited in A2E-Laden RPE by Blue-Light Illumination

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New retinal light damage QTL in mice with the light-sensitive RPE65 LEU variant

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

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Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

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Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

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Inhibition of lysosomal degradation in retinal pigment epithelium cells induces exocytosis of phagocytic residual material at the basolateral plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

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The association between host susceptibility factors and uveal melanoma: a meta-analysis

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Retinal degeneration from oxidative damage

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Effects of photodegradation on the physical and antioxidant properties of melanosomes isolated from retinal pigment epithelium.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

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An overview on the toxic morphological changes in the retinal pigment epithelium after systemic compound administration

1 reference

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12 December 2020

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The phototoxicity of aged human retinal melanosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

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UV-A induced oxidative stress is more prominent in naturally pigmented aged human RPE cells compared to non-pigmented human RPE cells independent of zinc treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

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Role of ocular melanin in ophthalmic physiology and pathology

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

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Retinopathy in mice induced by disrupted all-trans-retinal clearance

1 reference

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based on heuristic

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Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice

1 reference

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based on heuristic

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The role of the photoreceptor ABC transporter ABCA4 in lipid transport and Stargardt macular degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of fundus autofluorescence and retinal structure in patients with Stargardt disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoreceptor cell degeneration in Abcr (-/-) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scavenging or quenching effect of melanin on superoxide anion and singlet oxygen

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic Degradation of A2E, a Retinal Pigment Epithelial Lipofuscin Bisretinoid

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement System Dysregulation and Inflammation in the Retinal Pigment Epithelium of a Mouse Model for Stargardt Macular Degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related retinopathy in NRF2-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic analyses reveal cytoprotection by RPE melanosomes against non-photic stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bisretinoids of retinal pigment epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathological consequences of long-term mitochondrial oxidative stress in the mouse retinal pigment epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fiji: an open-source platform for biological-image analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative fundus autofluorescence in mice: correlation with HPLC quantitation of RPE lipofuscin and measurement of retina outer nuclear layer thickness

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fundus autofluorescence in the Abca4(-/-) mouse model of Stargardt disease--correlation with accumulation of A2E, retinal function, and histology

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutral pH and copper ions promote eumelanogenesis after the dopachrome stage

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinal Histopathology in Eyes from a Patient with Stargardt disease caused by Compound Heterozygous ABCA4 Mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Foveal sparing in Stargardt disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigations of riboflavin photolysis via coloured light in the nitro blue tetrazolium assay for superoxide dismutase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting Progression of ABCA4-Associated Retinal Degenerations Based on Longitudinal Measurements of the Leading Disease Front

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinal pigment epithelial integrity is compromised in the developing albino mouse retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis for photoreceptor outer segment architecture

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of oxidative and nitrosative stresses in human retinal pigment epithelial cells by all-trans-retinal

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trainable Weka Segmentation: a machine learning tool for microscopy pixel classification

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox Active Transition Metal ions Make Melanin Susceptible to Chemical Degradation Induced by Organic Peroxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/30038866

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.7717/PEERJ.5215

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30038866%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

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Europe PubMed Central

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13 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30038866%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

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