Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? (Q64955369)

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scientific article published on 15 May 2019

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English	Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging?	scientific article published on 15 May 2019

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Europe PubMed Central

PMC publication ID

6529819

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1 July 2019

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http://europepmc.org/abstract/PMC/6529819

review article

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Europe PubMed Central

title

Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? (English)

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Europe PubMed Central

PMC publication ID

6529819

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1 July 2019

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http://europepmc.org/abstract/PMC/6529819

main subject

progeria

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author

Igor Kireev

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Igor I Kireev

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4

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Vasily V Ashapkin

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1

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Europe PubMed Central

PMC publication ID

6529819

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1 July 2019

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http://europepmc.org/abstract/PMC/6529819

Lyudmila I Kutueva

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2

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Europe PubMed Central

PMC publication ID

6529819

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1 July 2019

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http://europepmc.org/abstract/PMC/6529819

Svetlana Y Kurchashova

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3

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Europe PubMed Central

PMC publication ID

6529819

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1 July 2019

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http://europepmc.org/abstract/PMC/6529819

publication date

15 May 2019

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6529819

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1 July 2019

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http://europepmc.org/abstract/PMC/6529819

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Frontiers in Genetics

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Europe PubMed Central

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6529819

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1 July 2019

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http://europepmc.org/abstract/PMC/6529819

volume

10

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Europe PubMed Central

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6529819

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1 July 2019

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http://europepmc.org/abstract/PMC/6529819

page(s)

455

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Europe PubMed Central

PMC publication ID

6529819

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1 July 2019

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http://europepmc.org/abstract/PMC/6529819

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Creative Commons Attribution 4.0 International

start time

15 May 2019

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April 2022 Public Data File from Crossref

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cites work

Lamin a truncation in Hutchinson-Gilford progeria.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Substrate-specific activation of sirtuins by resveratrol

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Mechanism of human SIRT1 activation by resveratrol

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Genomic instability in laminopathy-based premature aging

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Lamin A-dependent nuclear defects in human aging

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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After a decade of study-ING, a PHD for a versatile family of proteins

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Motif module map reveals enforcement of aging by continual NF-kappaB activity

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Perturbation of wild-type lamin A metabolism results in a progeroid phenotype

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Vitamin D and human health: lessons from vitamin D receptor null mice.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Tethering by lamin A stabilizes and targets the ING1 tumour suppressor

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Telomere length in Hutchinson-Gilford progeria syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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inferred from PubMed ID database lookup

Premature aging in vitamin D receptor mutant mice

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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The Ink4/Arf locus is a barrier for iPS cell reprogramming

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Epigenetic memory in induced pluripotent stem cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIRT6 promotes DNA repair under stress by activating PARP1

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A conserved splicing mechanism of the LMNA gene controls premature aging.

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12 December 2020

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Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Unique Preservation of Neural Cells in Hutchinson- Gilford Progeria Syndrome Is Due to the Expression of the Neural-Specific miR-9 MicroRNA

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

based on heuristic

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Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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A ceRNA analysis on LMNA gene focusing on the Hutchinson-Gilford progeria syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

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The hallmarks of aging

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Investigation of age-related changes in LMNA splicing and expression of progerin in human skeletal muscles

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Antagonistic functions of LMNA isoforms in energy expenditure and lifespan

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

based on heuristic

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Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases

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https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

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Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior

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https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aged iPSCs display an uncommon mitochondrial appearance and fail to undergo in vitro neurogenesis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Nrf2 signaling and longevity in naturally long-lived rodents

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced SRSF5 Protein Expression Reinforces Lamin A mRNA Production in HeLa Cells and Fibroblasts of Progeria Patients.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of nuclear lamina growth in interphase

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repression of the Antioxidant NRF2 Pathway in Premature Aging

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aged induced pluripotent stem cell (iPSCs) as a new cellular model for studying premature aging

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging as an Epigenetic Phenomenon

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reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired DNA demethylation of C/EBP sites causes premature aging

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and studies

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31156709

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12 December 2020

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Identifiers

DOI

10.3389/FGENE.2019.00455

1 reference

stated in

Europe PubMed Central

PMC publication ID

6529819

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6529819

PMC publication ID

6529819

1 reference

stated in

Europe PubMed Central

PMC publication ID

6529819

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6529819

PubMed publication ID

31156709

1 reference

stated in

Europe PubMed Central

PMC publication ID

6529819

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6529819

 

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