Proinsulin misfolding is an early event in the progression to type 2 diabetes. (Q64935836)

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1 May 2020

title

Proinsulin misfolding is an early event in the progression to type 2 diabetes (English)

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1 May 2020

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1 May 2020

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1 May 2020

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1 May 2020

Leena Haataja

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1 May 2020

Anita Pottekat

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1 May 2020

Fawnnie Pamenan

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Soohyun Kim

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1 May 2020

Lori M Zeltser

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1 May 2020

James C Paton

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1 May 2020

Pamela Itkin-Ansari

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1 May 2020

Ming Liu

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1 May 2020

Adrienne W Paton

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1 May 2020

publication date

11 June 2019

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volume

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describes a project that uses

1 May 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

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Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport

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Control of Precursor Maturation and Disposal Is an Early Regulative Mechanism in the Normal Insulin Production of Pancreatic β-Cells

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Endoplasmic reticulum stress and type 2 diabetes

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Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes

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Proinsulin intermolecular interactions during secretory trafficking in pancreatic β cells

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Changes in beta cell function occur in prediabetes and early disease in the Lepr (db) mouse model of diabetes

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Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.

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12 December 2020

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.

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12 December 2020

IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells.

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12 December 2020

Crosstalk Between the Unfolded Protein Response, MicroRNAs, and Insulin Signaling Pathways: In Search of Biomarkers for the Diagnosis and Treatment of Type 2 Diabetes.

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Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes

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Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

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Identifiers

DOI

10.7554/ELIFE.44532

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31184302%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

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1 May 2020

PubMed publication ID

31184302

1 reference

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