Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils (Q64271418)

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scientific article published on 20 May 2019

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English	Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils	scientific article published on 20 May 2019

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scholarly article

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27 April 2020

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils (English)

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27 April 2020

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infectious disease

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Alexandra Ehrens

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27 April 2020

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27 April 2020

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Stefan J Frohberger

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27 April 2020

Jesuthas Ajendra

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27 April 2020

Jayagopi Surendar

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27 April 2020

Wiebke Stamminger

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27 April 2020

Benedikt C Buerfent

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27 April 2020

Katrin Gentil

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27 April 2020

Achim Hoerauf

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27 April 2020

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20 May 2019

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27 April 2020

Parasites and Vectors

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27 April 2020

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27 April 2020

1

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27 April 2020

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27 April 2020

Onchocerca volvulus: in vitro killing of microfilaria by neutrophils and eosinophils from experimentally infected chimpanzees

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the immune response in lymphatic filariasis and onchocerciasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eosinophil-larval-interaction in onchocerciasis: heterogeneity of in vitro adherence of eosinophils to infective third and fourth stage larvae and microfilariae of Onchocerca volvulus

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro killing of microfilariae of Brugia pahangi and Brugia malayi by eosinophil granule proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular killing of microfilariae of Onchocerca volvulus: eosinophil and neutrophil-mediated immune serum-dependent destruction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Infection of BALB/c mice with the filarial nematode Litomosoides sigmodontis: role of CD4+ T cells in controlling larval development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-5 is essential for vaccine-mediated immunity but not innate resistance to a filarial parasite.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new mechanism for IL-5-dependent helminth control: neutrophil accumulation and neutrophil-mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Litomosoides sigmodontis in mice: reappraisal of an old model for filarial research

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-5 is essential for vaccine-induced protection and for resolution of primary infection in murine filariasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-4 is essential for the control of microfilariae in murine infection with the filaria Litomosoides sigmodontis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of interferon-gamma confers impaired neutrophil granulocyte function and imparts prolonged survival of adult filarial worms in murine filariasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutrophil accumulation around Onchocerca worms and chemotaxis of neutrophils are dependent on Wolbachia endobacteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the spleen in controlling the number of microfilariae (Dirofilaria immitis, D. repens, Litomosoides carinii and Dipetalonema witei) in the blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunomodulation by filarial nematodes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective immune mechanisms in helminth infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine asthma model

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microfilariae of the filarial nematode Litomosoides sigmodontis exacerbate the course of lipopolysaccharide-induced sepsis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Of mice, cattle, and humans: the immunology and treatment of river blindness

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Filarial lymphedema is characterized by antigen-specific Th1 and th17 proinflammatory responses and a lack of regulatory T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternatively activated and immunoregulatory monocytes in human filarial infections

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The chemokine CXCL12 is essential for the clearance of the filaria Litomosoides sigmodontis in resistant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-cell-derived, but not B-cell-derived, IL-10 suppresses antigen-specific T-cell responses in Litomosoides sigmodontis-infected mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eotaxin-1 is involved in parasite clearance during chronic filarial infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eosinophils are important for protection, immunoregulation and pathology during infection with nematode microfilariae

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Host protective roles of type 2 immunity: parasite killing and tissue repair, flip sides of the same coin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human CD117 (cKit)+ innate lymphoid cells have a discrete transcriptional profile at homeostasis and are expanded during filarial infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nematode-induced interference with vaccination efficacy targets follicular T helper cell induction and is preserved after termination of infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Litomosoides sigmodontis induces TGF-β receptor responsive, IL-10-producing T cells that suppress bystander T-cell proliferation in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ten Weeks of Infection with a Tissue-Invasive Helminth Protects against Local Immune Complex-Mediated Inflammation, but Not Cutaneous Type I Hypersensitivity, in Previously Sensitized Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pleural cavity type 2 innate lymphoid cells precede Th2 expansion in murine Litomosoides sigmodontis infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of RELMα and RELMβ Single- and Double-Gene-Deficient Mice Reveals that RELMα Expression Dictates Inflammation and Worm Expulsion in Hookworm Infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutropenic Mice Provide Insight into the Role of Skin-Infiltrating Neutrophils in the Host Protective Immunity against Filarial Infective Larvae

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4/5 signalling plays an important role during Litomosoides sigmodontis infection, influencing both immune system regulation and tissue pathology in the thoracic cavity

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dirofilaria immitis Microfilariae and Third-Stage Larvae Induce Canine NETosis Resulting in Different Types of Neutrophil Extracellular Traps.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31109364

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1186/S13071-019-3502-Z

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27 April 2020

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Europe PubMed Central

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27 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31109364%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

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