TIGIT signaling restores suppressor function of Th1 Tregs (Q64262028)

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Pierre-Paul Axisa

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Emily R Singer

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Neal M Nolan

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Margarita Dominguez-Villar

SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL

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language of work or name

English

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publication date

7 February 2019

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12 December 2020

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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12 December 2020

Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding

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12 December 2020

Two distinct waves of membrane-proximal B cell antigen receptor signaling differentially regulated by Src homology 2-containing inositol polyphosphate 5-phosphatase

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12 December 2020

Suppressor T cells in human diseases

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12 December 2020

CD226 Gly307Ser association with multiple autoimmune diseases

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12 December 2020

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

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12 December 2020

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses

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12 December 2020

A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC

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12 December 2020

The role of the CD58 locus in multiple sclerosis

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12 December 2020

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

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12 December 2020

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

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12 December 2020

CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.

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12 December 2020

Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

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12 December 2020

Interleukin-12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis.

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12 December 2020

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

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12 December 2020

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

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12 December 2020

The TIGIT/CD226 axis regulates human T cell function

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12 December 2020

Fiji: an open-source platform for biological-image analysis

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12 December 2020

T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2

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12 December 2020

Novel Foxo1-dependent transcriptional programs control T(reg) cell function

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12 December 2020

Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells

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12 December 2020

Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

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12 December 2020

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses

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12 December 2020

The regulatory T cell effector molecule fibrinogen-like protein 2 is necessary for the development of rapamycin-induced tolerance to fully MHC-mismatched murine cardiac allografts

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12 December 2020

TLR4 regulates IFN-γ and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation

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12 December 2020

The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function

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12 December 2020

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

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12 December 2020

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.

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12 December 2020

Multiple sclerosis associated genetic variants of CD226 impair regulatory T cell function

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12 December 2020

Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.

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12 December 2020

DNAM-1 controls NK cell activation via an ITT-like motif

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12 December 2020

Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity.

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12 December 2020

Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells

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12 December 2020

AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease

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12 December 2020

Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target.

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12 December 2020

Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival.

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12 December 2020

Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.

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12 December 2020

CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms.

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12 December 2020

Regulatory T cells in autoimmune disease

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12 December 2020

TIGIT immune checkpoint blockade restores CD8+ T-cell immunity against multiple myeloma

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12 December 2020

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+ T cells

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12 December 2020

Reprogramming human T cell function and specificity with non-viral genome targeting

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12 December 2020

CD226 opposes TIGIT to disrupt Tregs in melanoma

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12 December 2020

Activated β-catenin in Foxp3 regulatory T cells links inflammatory environments to autoimmunity

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12 December 2020