Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma (Q64066124)

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30 April 2020

title

Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma (English)

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Pierfrancesco Tassone

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Pierfrancesco Tassone

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Pierosandro Tagliaferri

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Maria Cucè

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Maria Eugenia Gallo Cantafio

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Maria Anna Siciliano

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Caterina Riillo

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Daniele Caracciolo

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Francesca Scionti

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Nicoletta Staropoli

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Katia Grillone

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Vito Barbieri

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Mariamena Arbitrio

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Maria Teresa Di Martino

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Nicola Amodio

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language of work or name

English

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publication date

21 March 2019

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Journal of Hematology & Oncology

30 April 2020

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Creative Commons Attribution 4.0 International

30 April 2020

start time

21 March 2019

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April 2022 Public Data File from Crossref

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Cytoscape

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9 June 2022

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CZ Software Mentions: A large dataset of software mentions in the biomedical literature

cites work

Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma

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Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation

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Chk2 activates E2F-1 in response to DNA damage

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HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells

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The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

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Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis

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A review of trabectedin (ET-743): a unique mechanism of action.

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A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma

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Histone H2AX phosphorylation: a marker for DNA damage

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MiR-15a, miR-16-1 and miR-17-92 cluster expression are linked to poor prognosis in multiple myeloma

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CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data

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Analysis of DNA repair-related genes in breast cancer reveals CUL4A ubiquitin ligase as a novel biomarker of trabectedin response.

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Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

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Immunologic microenvironment and personalized treatment in multiple myeloma.

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A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells.

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12 December 2020

DNA repair pathways in human multiple myeloma: role in oncogenesis and potential targets for treatment

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12 December 2020

Natural killer T cell defects in multiple myeloma and the impact of lenalidomide therapy

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12 December 2020

Trabectedin mechanism of action: what's new?

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12 December 2020

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins

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The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells.

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Automated quantification reveals hyperglycemia inhibits endothelial angiogenic function

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CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma

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A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy

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12 December 2020

Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1.

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Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatoma.

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The cellular immune system in myelomagenesis: NK cells and T cells in the development of myeloma [corrected] and their uses in immunotherapies

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Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition

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Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group

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Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells

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The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma

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A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells.

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Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma.

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Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay

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Silencing NKG2D ligand-targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer

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ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma

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Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance.

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Resveratrol promotes MICA/B expression and natural killer cell lysis of breast cancer cells by suppressing c-Myc/miR-17 pathway

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Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation.

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Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92

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miR-22 suppresses DNA ligase III addiction in multiple myeloma

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12 December 2020

10.1186/S13045-019-0714-9

Identifiers

DOI

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Dimensions Publication ID

30 April 2020

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9 September 2019

https://scigraph.springernature.com/pub.10.1186/s13045-019-0714-9

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30 April 2020

PubMed publication ID

30898137

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