FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4 (Q64053257)

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scientific article published on 11 April 2019

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English	FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4	scientific article published on 11 April 2019

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30975104%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4 (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30975104%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Breast Cancer Stem Cells

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Endocrine Therapy

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Triple negative breast cancer

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neoplastic stem cells

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based on heuristic

inferred from title

cancer metastasis

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based on heuristic

inferred from title

Lana McClements

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30975104%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Robert B. Clarke

13

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3 May 2020

14

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3 May 2020

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Stephanie Annett

2

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3 May 2020

Anita Yakkundi

3

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3 May 2020

Martin O'Rourke

4

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3 May 2020

Andrea Valentine

5

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3 May 2020

Nermeen Moustafa

6

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3 May 2020

Abdelrahim Alqudah

7

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3 May 2020

Bruno M Simões

8

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3 May 2020

Fiona Furlong

9

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3 May 2020

Amy Short

10

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3 May 2020

Stuart A McIntosh

11

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3 May 2020

Helen O McCarthy

12

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3 May 2020

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publication date

11 April 2019

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3 May 2020

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30975104%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

19

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30975104%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

1

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3 May 2020

351

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Europe PubMed Central

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3 May 2020

copyright license

Creative Commons Attribution 4.0 International

11 April 2019

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April 2022 Public Data File from Crossref

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1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6460676/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Stem cells, cancer, and cancer stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of beta-catenin phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia requires notch signaling to maintain the undifferentiated cell state

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breast cancer stem cells: something out of notching?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breast cancer stem cells and their role in resistance to endocrine therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The therapeutic and diagnostic potential of FKBPL; a novel anticancer protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-α status

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting treatment-resistant breast cancer stem cells with FKBPL and its peptide derivative, AD-01, via the CD44 pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sox2 promotes tamoxifen resistance in breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delta-like ligand 4 (DLL4) in the plasma and neoplastic tissues from breast cancer patients: correlation with metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breast cancer stem cells: Multiple capacities in tumor metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant expression of δ-like ligand 4 contributes significantly to axillary lymph node metastasis and predicts postoperative outcome in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD44 increases the efficiency of distant metastasis of breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FKBPL: a marker of good prognosis in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Role of Peptidyl Prolyl Isomerases in Aging and Vascular Diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breast cancer intrinsic subtype classification, clinical use and future trends

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MMGZ01, an anti-DLL4 monoclonal antibody, promotes nonfunctional vessels and inhibits breast tumor growth.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Review of Systemic Treatment in Metastatic Triple-Negative Breast Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of delta-like ligand-4 in chemoresistance against docetaxel in MCF-7 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DLL4 overexpression increases gastric cancer stem/progenitor cell self-renewal ability and correlates with poor clinical outcome via Notch-1 signaling pathway activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of Notch4/STAT3 signaling in epithelial-mesenchymal transition of tamoxifen-resistant human breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneous Cell Types in Single-cell-derived Clones of MCF7 and MDA-MB-231 Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flubendazole elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/30975104

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S12885-019-5500-0

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30975104%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

Dimensions Publication ID

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9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12885-019-5500-0

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30975104%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30975104%20AND%20SRC:MED&resulttype=core&format=json

3 May 2020

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