Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells. (Q53278762)

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scientific article published on 31 December 2010

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English	Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells.	scientific article published on 31 December 2010

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19 January 2020

Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells (English)

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19 January 2020

3

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19 January 2020

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Su Hyun Park

1

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19 January 2020

Tae Jun Park

2

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19 January 2020

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31 December 2010

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19 January 2020

Experimental Cell Research

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19 January 2020

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19 January 2020

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19 January 2020

941-954

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19 January 2020

Intracellular determinants of cell aging.

1 reference

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Replicative senescence: the human fibroblast comes of age.

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The biochemistry of mammalian senescence

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Growth stimulation leads to cellular senescence when the cell cycle is blocked

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Cytoplasmic retention of p-Erk1/2 and nuclear accumulation of actin proteins during cellular senescence in human diploid fibroblasts

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Nuclear accumulation of globular actin as a cellular senescence marker

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Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein

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Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes

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The nuclear pore complex

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Nuclear envelope permeability

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Permeability of single nuclear pores

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Nuclear pore complex is able to transport macromolecules with diameters of about 39 nm

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Kinetic analysis of translocation through nuclear pore complexes

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Transport routes through the nuclear pore complex

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Transport into and out of the cell nucleus

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A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes

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In vitro mutagenesis of a putative DNA binding domain of SV40 large-T

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The role of Ran in nuclear function.

1 reference

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RanGAP1 induces GTPase activity of nuclear Ras-related Ran

1 reference

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Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide

1 reference

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Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

1 reference

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A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

1 reference

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7 January 2021

A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

1 reference

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7 January 2021

RanBP2 associates with Ubc9p and a modified form of RanGAP1

1 reference

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The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA

1 reference

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The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

1 reference

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Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence

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Phosphorylated extracellular signal-regulated protein kinases 1 and 2 phosphorylate Sp1 on serine 59 and regulate cellular senescence via transcription of p21Sdi1/Cip1/Waf1.

1 reference

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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Cofilin is a component of intranuclear and cytoplasmic actin rods induced in cultured cells

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Latrunculin B or ATP depletion induces cofilin-dependent translocation of actin into nuclei of mast cells

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Reactivation of phosphorylated actin depolymerizing factor and identification of the regulatory site

1 reference

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7 January 2021

Phosphorylation of Ser-3 of cofilin regulates its essential function on actin

1 reference

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Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

1 reference

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7 January 2021

Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.12.023

7 January 2021

Cofilin, a protein in porcine brain that binds to actin filaments and inhibits their interactions with myosin and tropomyosin

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7 January 2021

Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export

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Nucleocytoplasmic transport of proteins

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Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor

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7 January 2021

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1 reference

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The Kinetic Mechanism of Ran-Nucleotide Exchange Catalyzed by RCC1

1 reference

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Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast

1 reference

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Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1

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Mechanism of the stress-induced collapse of the Ran distribution

1 reference

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Complex II Defect via Down-regulation of Iron-Sulfur Subunit Induces Mitochondrial Dysfunction and Cell Cycle Delay in Iron Chelation-induced Senescence-associated Growth Arrest

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Nucleotide-specific interaction of Ran/TC4 with nuclear transport factors NTF2 and p97.

1 reference

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7 January 2021

Nuclear import of Ran is mediated by the transport factor NTF2.

1 reference

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7 January 2021

NTF2 mediates nuclear import of Ran.

1 reference

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7 January 2021

An ATP-dependent activity that releases RanGDP from NTF2.

1 reference

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7 January 2021

Nuclear transport factor p10/NTF2 functions as a Ran-GDP dissociation inhibitor (Ran-GDI).

1 reference

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The KKRKK sequence is involved in heat shock-induced nuclear translocation of the 18-kDa actin-binding protein, cofilin

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7 January 2021

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19 January 2020

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19 January 2020

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