Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on protease digestion. (Q52725083)

http://europepmc.org/abstract/PMC/5753150

6 May 2018

title

Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on protease digestion. (English)

1 reference

http://europepmc.org/abstract/PMC/5753150

6 May 2018

author name string

Anne-Katrin Stegemann

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29564015%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Kristin Folmert

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29564015%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Damian Klemczak

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29564015%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Johann Moschner

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29564015%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Michelle Kube

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29564015%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

publication date

22 December 2017

1 reference

http://europepmc.org/abstract/PMC/5753150

6 May 2018

published in

Beilstein Journal of Organic Chemistry

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7 June 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29564015%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

2869-2882

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29564015%20AND%20SRC:MED&resulttype=core&format=json

Oral Administration of Peptide-Based Drugs: Beyond Lipinski's Rule.

7 June 2020

cites work

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Peptide therapeutics: current status and future directions

22 May 2018

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Synthesis of enantiomerically pure (2S,3S)-5,5,5-trifluoroisoleucine and (2R,3S)-5,5,5-trifluoro-allo-isoleucine

22 May 2018

1 reference

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Peptide modification by incorporation ofα-trifluoromethyl substituted amino acids.

22 May 2018

1 reference

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Specificity of proteinase K at P2 to P3' sub-sites and its comparison to other serine proteases.

22 May 2018

1 reference

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Comparison of the structures and stabilities of coiled-coil proteins containing hexafluoroleucine andt-butylalanine provides insight into the stabilizing effects of highly fluorinated amino acid side-chains

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Structural basis for the enhanced stability of highly fluorinated proteins

22 May 2018

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Fluorinated amino acids: compatibility with native protein structures and effects on protein-protein interactions.

22 May 2018

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Residue-specific global fluorination of Candida antarctica lipase B in Pichia pastoris

22 May 2018

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A New Paradigm for Protein Design and Biological Self-Assembly

22 May 2018

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Synthetic therapeutic peptides: science and market

22 May 2018

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Proteolytic enzymes for peptide production

22 May 2018

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Therapeutic peptides: technological advances driving peptides into development

22 May 2018

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How C(alpha)-Fluoroalkyl amino acids and peptides interact with enzymes: studies concerning the influence on proteolytic stability, enzymatic resolution and peptide coupling

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

The catalytic triad of serine peptidases

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Purification and specificity of pancreatic elastase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Protease-catalyzed peptide synthesis for the site-specific incorporation of alpha-fluoroalkyl amino acids into peptides

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Fluorinated amino acids in protein design and engineering

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Serine protease mechanism and specificity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Structure and mechanism of the pepsin-like family of aspartic peptidases

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development

22 May 2018

1 reference

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Biosynthesis of a highly stable coiled-coil protein containing hexafluoroleucine in an engineered bacterial host

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability This work was supported by a grant from the U.S. Army Research Office. Y. Tang is supported by a Whitaker Graduate Research Fellowship. We thank Dr. Ga

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Stabilization of coiled-coil peptide domains by introduction of trifluoroleucine

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Specificity assay of serine proteinases by reverse-phase high-performance liquid chromatography analysis of competing oligopeptide substrate library.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

The two sides of enzyme-substrate specificity: lessons from the aspartic proteinases

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Therapeutic peptides revisited

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Structural and energetic determinants of the S1-site specificity in serine proteases

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Structure of the complex of proteinase K with a substrate analogue hexapeptide inhibitor at 2.2-A resolution

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Role of the S' subsites in serine protease catalysis. Active-site mapping of rat chymotrypsin, rat trypsin, alpha-lytic protease, and cercarial protease from Schistosoma mansoni.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Crystal structure of human pepsin and its complex with pepstatin

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

On the size of the active site in proteases. I. Papain

22 May 2018

1 reference

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22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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22 May 2018

1 reference

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22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

The structure and function of the aspartic proteinases

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

The specificity of proteinase K against oxidized insulin B chain

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Purification and characterization of two human pancreatic elastases

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

New Data on Pepsin Mechanism and Specificity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Fluorine teams up with water to restore inhibitor activity to mutant BPTI.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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13 August 2018

1 reference

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13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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13 August 2018

1 reference

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13 August 2018

1 reference

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13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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1 reference

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13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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13 August 2018

1 reference

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13 August 2018

1 reference

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13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

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13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5753150

Proteinase K from the mold Tritirachium album Limber. Specificity and mode of action

30 November 2018

1 reference

12 December 2020

The active site of porcine elastase

1 reference

12 December 2020

Inhibition of chymotrypsin by peptidyl trifluoromethyl ketones: determinants of slow-binding kinetics

1 reference

12 December 2020

X-ray and model-building studies on the specificity of the active site of proteinase K

1 reference

12 December 2020

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1 reference

12 December 2020

Mapping of the S' subsites of porcine pancreatic and human leucocyte elastases

1 reference

12 December 2020

Both Subcutaneously and Intravenously Administered Glucagon-Like Peptide I Are Rapidly Degraded From the NH2-Terminus in Type II Diabetic Patients and in Healthy Subjects

1 reference

12 December 2020

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1 reference

12 December 2020

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1 reference

12 December 2020

Proteolytically stable peptides by incorporation of α-Tfm amino acids

1 reference

12 December 2020

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1 reference

12 December 2020

Catalytic efficiencies of alkaline proteinases from microorganisms

1 reference

12 December 2020

Fluorine in protein environments: a QM and MD study

1 reference

12 December 2020

Peptide modification by introduction of?-trifluoromethyl substituted amino acids

1 reference

12 December 2020

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1 reference

12 December 2020

Identifiers

DOI

10.3762/BJOC.13.279

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29564015%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29564015%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

29564015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29564015%20AND%20SRC:MED&resulttype=core&format=json