Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity. (Q52680647)

5 May 2018

title

Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity. (English)

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5 May 2018

author name string

Jeremiah W Hanes

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5 May 2018

Yali Zhu

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5 May 2018

Deborah S Parris

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5 May 2018

Kenneth A Johnson

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5 May 2018

language of work or name

English

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publication date

14 June 2007

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5 May 2018

Journal of Biological Chemistry

published in

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5 May 2018

volume

282

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issue

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5 May 2018

page(s)

25159-25167

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5 May 2018

The selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Reproduced from Proc. Natl. Acad. Sci. USA 74, 5716-5720 (1977)

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Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine

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Liver failure caused by herpes simplex virus thymidine kinase plus ganciclovir therapy is associated with mitochondrial dysfunction and mitochondrial DNA depletion

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Ganciclovir nucleotides accumulate in mitochondria of rat liver cells expressing the herpes simplex virus thymidine kinase gene

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Slow rate of phosphodiester bond formation accounts for the strong bias that Taq DNA polymerase shows against 2',3'-dideoxynucleotide terminators

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Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondri

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Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors

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Solution structure of a DNA decamer containing the antiviral drug ganciclovir: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement

21 January 2018

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Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1

21 January 2018

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Nucleoside reverse transcriptase inhibitor usage and the incidence of peripheral neuropathy in HIV/AIDS patients.

21 January 2018

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Fidelity of nucleotide incorporation by human mitochondrial DNA polymerase

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M703972200

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5 May 2018

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5 May 2018