Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney. (Q52659737)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29530879%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29530879%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29530879%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29530879%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Uyen Tran

1 reference

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20 March 2020

language of work or name

English

0 references

publication date

22 March 2018

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20 March 2020

1 reference

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20 March 2020

volume

145

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20 March 2020

issue

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Primary Cilium-Dependent Signaling Mechanisms.

20 March 2020

cites work

1 reference

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Primary Cilia in Cystic Kidney Disease

7 September 2018

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Ciliary Mechanisms of Cyst Formation in Polycystic Kidney Disease

7 September 2018

1 reference

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The Role of G-protein Coupled Receptor Proteolytic Site (GPS) Cleavage in Polycystin-1 Biogenesis, Trafficking and Function

7 September 2018

1 reference

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The polycystin complex mediates Wnt/Ca(2+) signalling.

7 September 2018

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Heterotrimeric G protein signaling in polycystic kidney disease

7 September 2018

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From Bench to Bedside: New Approaches to Therapeutic Discovery for Heart Failure

7 September 2018

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7 September 2018

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The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

7 September 2018

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The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease

7 September 2018

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7 September 2018

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Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS site

7 September 2018

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Nephron Patterning: Lessons from Xenopus, Zebrafish, and Mouse Studies

7 September 2018

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The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking.

7 September 2018

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Ins and outs of GPCR signaling in primary cilia

7 September 2018

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Altered trafficking and stability of polycystins underlie polycystic kidney disease

7 September 2018

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Translational research in ADPKD: lessons from animal models

7 September 2018

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G-protein βγ subunit dimers modulate kidney repair after ischemia-reperfusion injury in rats

7 September 2018

1 reference

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Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease

7 September 2018

1 reference

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Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

7 September 2018

1 reference

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MicroRNAs are critical regulators of tuberous sclerosis complex and mTORC1 activity in the size control of the Xenopus kidney

7 September 2018

1 reference

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Why and how we determine nephron number.

7 September 2018

1 reference

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The bigger the better: determining nephron size in kidney

7 September 2018

1 reference

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Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Matching structure with function: the GAIN domain of adhesion-GPCR and PKD1-like proteins

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Sticky signaling--adhesion class G protein-coupled receptors take the stage

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Wtip and Vangl2 are required for mitotic spindle orientation and cloaca morphogenesis

7 September 2018

1 reference

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Cell polarity and cystic kidney disease

7 September 2018

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Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension

7 September 2018

1 reference

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Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

7 September 2018

1 reference

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Signaling property study of adhesion G-protein-coupled receptors

7 September 2018

1 reference

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The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism

7 September 2018

1 reference

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Why kidneys fail in autosomal dominant polycystic kidney disease

7 September 2018

1 reference

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Understanding Molecular Recognition by G protein βγ Subunits on the Path to Pharmacological Targeting

7 September 2018

1 reference

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Xenopus pronephros development—past, present, and future

7 September 2018

1 reference

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Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Identification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Activator of G protein signaling 3 promotes epithelial cell proliferation in PKD.

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Notch signaling, wt1 and foxc2 are key regulators of the podocyte gene regulatory network in Xenopus.

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Polycystin-1 protein level determines activity of the Galpha12/JNK apoptosis pathway

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Loss of oriented cell division does not initiate cyst formation

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Polycystic kidney disease

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

G protein βγ subunits: central mediators of G protein-coupled receptor signaling

7 September 2018

1 reference

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Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Fish and frogs: models for vertebrate cilia signaling

7 September 2018

1 reference

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Xenopus Bicaudal-C is required for the differentiation of the amphibian pronephros.

7 September 2018

1 reference

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G-protein-coupled receptors and cancer.

7 September 2018

1 reference

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Polycystic kidney disease: genes, proteins, animal models, disease mechanisms and therapeutic opportunities

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.

7 September 2018

1 reference

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Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Defective planar cell polarity in polycystic kidney disease

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Proximo-distal specialization of epithelial transport processes within the Xenopus pronephric kidney tubules

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Polycystin-1L2 is a novel G-protein-binding protein

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Removal of G(ialpha1) constraints on adenylyl cyclase in the hippocampus enhances LTP and impairs memory formation

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

7 September 2018

1 reference

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Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Interaction between RGS7 and polycystin

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene

7 September 2018

1 reference

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Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula

7 September 2018

1 reference

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G protein beta gamma subunits.

7 September 2018

1 reference

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PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

7 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5897598

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

7 September 2018

1 reference

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Polycystic kidney disease: The complete structure of the PKD1 gene and its protein

7 September 2018

1 reference

12 December 2020

Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2

1 reference

12 December 2020

Gating of the polycystin ion channel signaling complex in neurons and kidney cells

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12 December 2020

Surface plasmon resonance study of g protein/receptor coupling in a lipid bilayer-free system

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12 December 2020

Autosomal dominant polycystic kidney disease

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12 December 2020

Identifiers

DOI

10.1242/DEV.158931

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29530879%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29530879%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

29530879

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29530879%20AND%20SRC:MED&resulttype=core&format=json