Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism. (Q52592593)

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scientific article published on 11 April 2018

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English	Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism.	scientific article published on 11 April 2018

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 May 2018

http://europepmc.org/abstract/MED/29644527

Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism. (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 May 2018

http://europepmc.org/abstract/MED/29644527

author name string

Rai Ajit K Srivastava

1

1 reference

Europe PubMed Central

PubMed publication ID

4 May 2018

http://europepmc.org/abstract/MED/29644527

Joseph A Cornicelli

2

1 reference

Europe PubMed Central

PubMed publication ID

4 May 2018

http://europepmc.org/abstract/MED/29644527

Bruce Markham

3

1 reference

Europe PubMed Central

PubMed publication ID

4 May 2018

http://europepmc.org/abstract/MED/29644527

Charles L Bisgaier

4

1 reference

Europe PubMed Central

PubMed publication ID

4 May 2018

http://europepmc.org/abstract/MED/29644527

publication date

11 April 2018

1 reference

Europe PubMed Central

PubMed publication ID

4 May 2018

http://europepmc.org/abstract/MED/29644527

Molecular and Cellular Biochemistry

1 reference

Europe PubMed Central

PubMed publication ID

4 May 2018

http://europepmc.org/abstract/MED/29644527

copyright license

Creative Commons Attribution 4.0 International

11 April 2018

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April 2022 Public Data File from Crossref

copyright status

0 references

cis-acting elements responsible for interleukin-6 inducible C-reactive protein gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of sequences responsible for acute-phase induction of human C-reactive protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inducible expression of vascular cell adhesion molecule-1 by vascular smooth muscle cells in vitro and within rabbit atheroma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atherosclerosis: current understanding of mechanisms and future strategies in therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

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Comparative evaluation of the safety and efficacy of HMG-CoA reductase inhibitor monotherapy in the treatment of primary hypercholesterolemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of human C-reactive protein gene expression by two synergistic IL-6 responsive elements

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low Density Lipoprotein Oxidation and Its Pathobiological Significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

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A novel compound that elevates high density lipoprotein and activates the peroxisome proliferator activated receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

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Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

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Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atherosclerosis is an inflammatory disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transactivation of C-reactive protein by IL-6 requires synergistic interaction of CCAAT/enhancer binding protein beta (C/EBP beta) and Rel p50.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A major role for VCAM-1, but not ICAM-1, in early atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

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Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HMG-CoA reductase inhibitors reduce interleukin-6 synthesis in human vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation in atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relations of plasma high-sensitivity C-reactive protein to traditional cardiovascular risk factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6, TNF-alpha and atherosclerosis risk indicators in a healthy family population: the STANISLAS cohort.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and atherosclerosis: role of C-reactive protein in risk assessment

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational rearrangement in C-reactive protein is required for proinflammatory actions on human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of fenofibrate on the levels of high sensitivity C-reactive protein in dyslipidaemic hypertensive patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

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Pravastatin inhibits expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in Watanabe heritable hyperlipidemic rabbits: a new pleiotropic effect of statins

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and cardiovascular disease mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation, statin therapy, and risk of stroke after an acute coronary syndrome in the MIRACL study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1beta stimulates acute phase response and C-reactive protein synthesis by inducing an NFkappaB- and C/EBPbeta-dependent autocrine interleukin-6 loop

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translating molecular discoveries into new therapies for atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation, C-reactive protein, and atherothrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atorvastatin and fenofibrate increase apolipoprotein AV and decrease triglycerides by up-regulating peroxisome proliferator-activated receptor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation, autoimmunity, and atherosclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical implications of inflammation for cardiovascular primary prevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease &ndash; a perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of statin and fibrate treatment on inflammation in type 2 diabetes. A randomized, cross-over study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of adiponectin in TNF-α, IL-6, and IL-10 cytokine production from coronary artery disease macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein is released in the coronary circulation and causes endothelial dysfunction in patients with acute coronary syndromes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pro-atherogenic effects of macrophages are reduced upon formation of a complex between C-reactive protein and lysophosphatidylcholine

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of interleukin-1β inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: a phase IIb randomized, placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electronegative low-density lipoprotein increases C-reactive protein expression in vascular endothelial cells through the LOX-1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein is independently associated with coronary atherosclerosis burden among octogenarians

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein, but not low-density lipoprotein cholesterol levels, associate with coronary atheroma regression and cardiovascular events after maximally intensive statin therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of fenofibrate on lipid profile, endothelial dysfunction, and inflammatory markers in type 2 diabetes mellitus patients with typical and mixed dyslipidemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein levels in patients at cardiovascular risk: EURIKA study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation: in vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lowering C-reactive protein with statins after an ischemic stroke avoids mortality and readmissions. A prospective cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel anti-inflammatory natural product from Sphaeranthus indicus inhibits expression of VCAM1 and ICAM1, and slows atherosclerosis progression independent of lipid changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interplay between CRP, Atherogenic LDL, and LOX-1 and Its Potential Role in the Pathogenesis of Atherosclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of gemcabene as add-on to stable statin therapy in hypercholesterolemic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11010-018-3353-5

1 reference

Europe PubMed Central

PubMed publication ID

4 May 2018

http://europepmc.org/abstract/MED/29644527

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 May 2018

http://europepmc.org/abstract/MED/29644527

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