A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy. (Q52562248)

3 May 2018

http://europepmc.org/abstract/MED/29696628

title

A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy. (English)

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3 May 2018

http://europepmc.org/abstract/MED/29696628

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Mohammad Obaidul Hoque

series ordinal

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6540999&resulttype=core&format=json

14 May 2020

Masahiro Shibata

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6540999&resulttype=core&format=json

14 May 2020

Kendall Ham

series ordinal

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6540999&resulttype=core&format=json

14 May 2020

language of work or name

English

0 references

publication date

26 April 2018

1 reference

3 May 2018

http://europepmc.org/abstract/MED/29696628

published in

International Journal of Cancer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6540999&resulttype=core&format=json

14 May 2020

volume

143

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6540999&resulttype=core&format=json

14 May 2020

issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6540999&resulttype=core&format=json

14 May 2020

page(s)

2133-2144

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6540999&resulttype=core&format=json

Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1

14 May 2020

cites work

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12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

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12 December 2020

Drosophila warts--tumor suppressor and member of the myotonic dystrophy protein kinase family.

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12 December 2020

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

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12 December 2020

Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

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12 December 2020

The RUNX2 transcription factor cooperates with the YES-associated protein, YAP65, to promote cell transformation

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12 December 2020

The hippo pathway in human upper gastrointestinal dysplasia and carcinoma: a novel oncogenic pathway.

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12 December 2020

Yes-associated protein (YAP) functions as a tumor suppressor in breast.

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12 December 2020

The Hippo-YAP pathway: new connections between regulation of organ size and cancer

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12 December 2020

Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma

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12 December 2020

Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer

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12 December 2020

MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties.

1 reference

12 December 2020

Immunity, Inflammation, and Cancer

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12 December 2020

The Hippo pathway regulates Wnt/beta-catenin signaling

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12 December 2020

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

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12 December 2020

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

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12 December 2020

Pivotal Advance: Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE₂ catabolism in myeloid cells.

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12 December 2020

COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function

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12 December 2020

The Hippo Signaling Pathway in Development and Cancer

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12 December 2020

Genome-wide interrogation identifies YAP1 variants associated with survival of small-cell lung cancer patients

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12 December 2020

The prognostic value of RASSF1A promoter hypermethylation in non-small cell lung carcinoma: a systematic review and meta-analysis

1 reference

12 December 2020

COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells

1 reference

12 December 2020

Yes-associated protein 1 exhibits oncogenic property in gastric cancer and its nuclear accumulation associates with poor prognosis.

1 reference

12 December 2020

The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activation

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12 December 2020

Role of YAP/TAZ in mechanotransduction

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12 December 2020

miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer.

1 reference

12 December 2020

Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells.

1 reference

12 December 2020

PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment

1 reference

12 December 2020

Yes-associated protein promotes tumour development in luminal epithelial derived breast cancer

1 reference

12 December 2020

Hippo signaling in Drosophila: recent advances and insights

1 reference

12 December 2020

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

1 reference

12 December 2020

Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells

1 reference

12 December 2020

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

1 reference

12 December 2020

YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14.

1 reference

12 December 2020

Key role of the positive feedback between PGE(2) and COX2 in the biology of myeloid-derived suppressor cells

1 reference

12 December 2020

Nuclear expression of Yes-associated protein 1 correlates with poor prognosis in intestinal type gastric cancer

1 reference

12 December 2020

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

1 reference

12 December 2020

Expression of Yes-associated protein in non-small cell lung cancer and its relationship with clinical pathological factors

1 reference

12 December 2020

YES-associated protein 1 promotes adenocarcinoma growth and metastasis through activation of the receptor tyrosine kinase Axl.

1 reference

12 December 2020

Generation of myeloid-derived suppressor cells using prostaglandin E2.

1 reference

12 December 2020

Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma

1 reference

12 December 2020

M1 and M2 Macrophages: Oracles of Health and Disease

1 reference

12 December 2020

Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2-dependent mechanisms

1 reference

12 December 2020

Differential expression of Yes-associated protein and phosphorylated Yes-associated protein is correlated with expression of Ki-67 and phospho-ERK in colorectal adenocarcinoma

1 reference

12 December 2020

Cellular composition of the tumor microenvironment

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12 December 2020

Overexpression of YAP 1 contributes to progressive features and poor prognosis of human urothelial carcinoma of the bladder

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12 December 2020

History of myeloid-derived suppressor cells

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12 December 2020

Increased expression of Yes-associated protein 1 in hepatocellular carcinoma with stemness and combined hepatocellular-cholangiocarcinoma

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12 December 2020

MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer

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12 December 2020

Prognostic significance of microRNA-141 expression and its tumor suppressor function in human pancreatic ductal adenocarcinoma

1 reference

12 December 2020

Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis.

1 reference

12 December 2020

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

1 reference

12 December 2020

miR-375 inhibits proliferation of mouse pancreatic progenitor cells by targeting YAP1.

1 reference

12 December 2020

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

1 reference

12 December 2020

Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis.

1 reference

12 December 2020

Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response

1 reference

12 December 2020

Blockade of Fas signaling in breast cancer cells suppresses tumor growth and metastasis via disruption of Fas signaling-initiated cancer-related inflammation

1 reference

12 December 2020

Metabolic control of YAP and TAZ by the mevalonate pathway.

1 reference

12 December 2020

Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma

1 reference

12 December 2020

YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes.

1 reference

12 December 2020

The Hippo signaling pathway in stem cell biology and cancer

1 reference

12 December 2020

Expression and clinical significance of YAP, TAZ, and AREG in hepatocellular carcinoma

1 reference

12 December 2020

An integrative analysis of the tumorigenic role of TAZ in human non-small cell lung cancer.

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12 December 2020

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

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12 December 2020

KRAS and YAP1 converge to regulate EMT and tumor survival

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12 December 2020

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response

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12 December 2020

YAP1 is a potential biomarker for cetuximab resistance in head and neck cancer

1 reference

12 December 2020

YAP activation is an early event and a potential therapeutic target in liver cancer development.

1 reference

12 December 2020

Yes-associated protein (YAP) is differentially expressed in tumor and stroma according to the molecular subtype of breast cancer

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12 December 2020

YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression

1 reference

12 December 2020

Curcumin promotes KLF5 proteasome degradation through downregulating YAP/TAZ in bladder cancer cells.

1 reference

12 December 2020

Metaplastic carcinoma show different expression pattern of YAP compared to triple-negative breast cancer.

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12 December 2020

YAP/TEAD co-activator regulated pluripotency and chemoresistance in ovarian cancer initiated cells

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12 December 2020

Angiomotin decreases lung cancer progression by sequestering oncogenic YAP/TAZ and decreasing Cyr61 expression

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12 December 2020

Significant association of oncogene YAP1 with poor prognosis and cetuximab resistance in colorectal cancer patients

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12 December 2020

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

1 reference

12 December 2020

The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer

1 reference

12 December 2020

Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma.

1 reference

12 December 2020

YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells

1 reference

12 December 2020

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression

1 reference

12 December 2020

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

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12 December 2020

YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression

1 reference

12 December 2020

Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver

1 reference

12 December 2020

The Hippo pathway transcriptional co-activator, YAP, confers resistance to cisplatin in human oral squamous cell carcinoma

1 reference

12 December 2020

MicroRNA-506 inhibits gastric cancer proliferation and invasion by directly targeting Yap1.

1 reference

12 December 2020

R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability

1 reference

12 December 2020

Hsa-miR-132 inhibits proliferation of hepatic carcinoma cells by targeting YAP.

1 reference

12 December 2020

YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage

1 reference

12 December 2020

The Hippo transducers TAZ and YAP in breast cancer: oncogenic activities and clinical implications.

1 reference

12 December 2020

Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers

1 reference

12 December 2020

A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis.

1 reference

12 December 2020

MiR-497 Suppresses YAP1 and Inhibits Tumor Growth in Non-Small Cell Lung Cancer

1 reference

12 December 2020

Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors

1 reference

12 December 2020

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.

1 reference

12 December 2020

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

1 reference

12 December 2020

Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance

1 reference

12 December 2020

RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer

1 reference

12 December 2020

COX-2 promotes metastasis in nasopharyngeal carcinoma by mediating interactions between cancer cells and myeloid-derived suppressor cells

1 reference

12 December 2020

YAP and TAZ Take Center Stage in Cancer

1 reference

12 December 2020

Predictive biomarkers in PD-1/PD-L1 checkpoint blockade immunotherapy

1 reference

12 December 2020

Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation

1 reference

12 December 2020

YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins

1 reference

12 December 2020

Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

1 reference

12 December 2020

Functional genomics screen identifies YAP1 as a key determinant to enhance treatment sensitivity in lung cancer cells

1 reference

12 December 2020

Hippo pathway and breast cancer stem cells

1 reference

12 December 2020

RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

1 reference

12 December 2020

Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells

1 reference

12 December 2020

Lung cancer stem cells: The root of resistance

1 reference

12 December 2020

Expression of tumoral FOXP3 in gastric adenocarcinoma is associated with favorable clinicopathological variables and related with Hippo pathway

1 reference

12 December 2020

Yes associated protein is a poor prognostic factor in well-differentiated lung adenocarcinoma

1 reference

12 December 2020

Nuclear accumulation of Yes-Associated Protein (YAP) maintains the survival of doxorubicin-induced senescent cells by promoting survivin expression

1 reference

12 December 2020

Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling.

1 reference

12 December 2020

Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity

1 reference

12 December 2020

YAP induces cisplatin resistance through activation of autophagy in human ovarian carcinoma cells

1 reference

12 December 2020

Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

1 reference

12 December 2020

Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance.

1 reference

12 December 2020

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling

1 reference

12 December 2020

YAP Mediates Tumorigenesis in Neurofibromatosis Type 2 by Promoting Cell Survival and Proliferation through a COX-2-EGFR Signaling Axis

1 reference

12 December 2020

MicroRNA-138 acts as a tumor suppressor in non small cell lung cancer via targeting YAP1

1 reference

12 December 2020

YAP promotes erlotinib resistance in human non-small cell lung cancer cells

1 reference

12 December 2020

Loss of MiR-424-3p, not miR-424-5p, confers chemoresistance through targeting YAP1 in non-small cell lung cancer

1 reference

12 December 2020

Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma.

1 reference

12 December 2020

AKT-STAT3 Pathway as a Downstream Target of EGFR Signaling to Regulate PD-L1 Expression on NSCLC cells.

1 reference

12 December 2020

Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies

1 reference

12 December 2020

Immunomodulatory Function of the Tumor Suppressor p53 in Host Immune Response and the Tumor Microenvironment

1 reference

12 December 2020

Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell

1 reference

12 December 2020

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells.

1 reference

12 December 2020

YAP1 regulates ABCG2 and cancer cell side population in human lung cancer cells

1 reference

12 December 2020

PD-1 and its ligands are important immune checkpoints in cancer

1 reference

12 December 2020

Regulatory T cells in cancer immunotherapy

1 reference

12 December 2020

Hippo vs. Crab: tissue-specific functions of the mammalian Hippo pathway

1 reference

12 December 2020

Single tumor-initiating cells evade immune clearance by recruiting type II macrophages

1 reference

12 December 2020

The expanding role of immunotherapy.

1 reference

12 December 2020

Molecular Features of the YAP Inhibitor Verteporfin: Synthesis of Hexasubstituted Dipyrrins as Potential Inhibitors of YAP/TAZ, the Downstream Effectors of the Hippo Pathway

1 reference

12 December 2020

YAP-1 Promotes Tregs Differentiation in Hepatocellular Carcinoma by Enhancing TGFBR2 Transcription

1 reference

12 December 2020

YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKɛ-mediated phosphorylation.

1 reference

12 December 2020

SPIN90 Depletion and Microtubule Acetylation Mediate Stromal Fibroblast Activation in Breast Cancer Progression

1 reference

12 December 2020

Hippo effector YAP directly regulates the expression of PD-L1 transcripts in EGFR-TKI-resistant lung adenocarcinoma

1 reference

12 December 2020

PRKCI promotes immune suppression in ovarian cancer

1 reference

12 December 2020

Myeloid suppressor cells in cancer and autoimmunity

1 reference

12 December 2020

Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance.

1 reference

12 December 2020

Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma

1 reference

12 December 2020

YAP1 and COX2 Coordinately Regulate Urothelial Cancer Stem-like Cells

1 reference

12 December 2020

YAP regulates PD-L1 expression in human NSCLC cells

1 reference

12 December 2020

Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts.

1 reference

12 December 2020

Identifiers

DOI

10.1002/IJC.31561

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6540999&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6540999&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6540999&resulttype=core&format=json