Analysis of Clinical Drug-Drug Interaction Data To Predict Magnitudes of Uncharacterized Interactions between Antiretroviral Drugs and Comedications. (Q52312048)

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scientific article published on 23 April 2018

Language	Label	Description	Also known as
English	Analysis of Clinical Drug-Drug Interaction Data To Predict Magnitudes of Uncharacterized Interactions between Antiretroviral Drugs and Comedications.	scientific article published on 23 April 2018

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

Analysis of Clinical Drug-Drug Interaction Data To Predict Magnitudes of Uncharacterized Interactions between Antiretroviral Drugs and Comedications. (English)

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

drug interaction

0 references

Manuel Battegay

3

object named as

Manuel Battegay

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

author name string

Felix Stader

1

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

Hannah Kinvig

2

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

Saye Khoo

4

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

Andrew Owen

5

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

Marco Siccardi

6

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

Catia Marzolini

7

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

language of work or name

0 references

publication date

26 June 2018

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

62

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

7

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

A strategy for early-risk predictions of clinical drug-drug interactions involving the GastroPlusTM DDI module for time-dependent CYP inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Recent Advances in Development and Application of Physiologically-Based Pharmacokinetic (PBPK) Models: a Transition from Academic Curiosity to Regulatory Acceptance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Quantitative Prediction of Cytochrome P450 (CYP) 2D6-Mediated Drug Interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Clinical pharmacokinetics and pharmacodynamics of etravirine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Effects of oral posaconazole on the pharmacokinetic properties of oral and intravenous midazolam: a phase I, randomized, open-label, crossover study in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Pharmacokinetics of darunavir/ritonavir and ketoconazole following co-administration in HIV-healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Antiretroviral drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Prevalence and risk factors for clinically significant drug interactions with antiretroviral therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Cytochrome P450 3A: ontogeny and drug disposition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Effect of itraconazole and terbinafine on the pharmacokinetics and pharmacodynamics of midazolam in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Dose of midazolam should be reduced during diltiazem and verapamil treatments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Absence of interaction of cimetidine and ranitidine with intravenous and oral midazolam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Effect of single doses of cimetidine and ranitidine on the steady-state plasma levels of midazolam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

27 July 2018

Predicting the effect of cytochrome P450 inhibitors on substrate drugs: analysis of physiologically based pharmacokinetic modeling submissions to the US Food and Drug Administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Metabolism-related pharmacokinetic drug-drug interactions with tyrosine kinase inhibitors: current understanding, challenges and recommendations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1-Related Variability in Pharmacodynamics of Rosuvastatin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Polypharmacy, drug-drug interactions, and potentially inappropriate medications in older adults with human immunodeficiency virus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Clinical perspective on drug-drug interactions with the non-nucleoside reverse transcriptase inhibitor rilpivirine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Investigation of the effects of ketoconazole on the pharmacokinetics of macitentan, a novel dual endothelin receptor antagonist, in healthy subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Drug interactions in elderly individuals with the human immunodeficiency virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Effect of posaconazole on the pharmacokinetics of simvastatin and midazolam in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Critique of the two-fold measure of prediction success for ratios: application for the assessment of drug-drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Prevalence of comedications and effect of potential drug-drug interactions in the Swiss HIV Cohort Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Physiologically based mechanistic modelling to predict complex drug-drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut - the effect of diltiazem on th

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Effect of saquinavir-ritonavir on cytochrome P450 3A4 activity in healthy volunteers using midazolam as a probe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Ritonavir greatly impairs CYP3A activity in HIV infection with chronic viral hepatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Effect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Comparison of midazolam and simvastatin as cytochrome P450 3A probes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Pharmacokinetic interactions between indinavir plus ritonavir and calcium channel blockers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: results of AIDS Clinical Trials Group 5108 Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Oral administration of a low dose of midazolam (75 microg) as an in vivo probe for CYP3A activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Pharmacokinetic and Pharmacodynamic Interactions of Oral Midazolam with Ketoconazole, Fluoxetine, Fluvoxamine, and Nefazodone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

The interaction of saquinavir (soft gelatin capsule) with ketoconazole, erythromycin and rifampicin: comparison of the effect in healthy volunteers and in HIV-infected patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

The effects of the systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Cimetidine and ranitidine increase midazolam bioavailability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6021627

13 August 2018

Effect of itraconazole on the pharmacokinetics and pharmacodynamics of zolpidem

1 reference

https://pubmed.ncbi.nlm.nih.gov/29686151

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/29686151

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic and dynamic interaction study of zolpidem with ketoconazole, itraconazole, and fluconazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/29686151

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of oral posaconazole on the pharmacokinetics of cyclosporine and tacrolimus

1 reference

https://pubmed.ncbi.nlm.nih.gov/29686151

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of Risk for Clinically Significant Drug Interactions among HIV‐Infected Patients Receiving Antiretroviral Therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29686151

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

'In silico' simulations to assess the 'in vivo' consequences of 'in vitro' metabolic drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/29686151

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.00717-18

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

8 July 2018

http://europepmc.org/abstract/PMC/6021627

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