Physiological modeling of altered pharmacokinetics of a novel anticancer drug, UCN-01 (7-hydroxystaurosporine), caused by slow dissociation of UCN-01 from human alpha1-acid glycoprotein. (Q52076650)

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scientific article published in May 2000

Language	Label	Description	Also known as
English	Physiological modeling of altered pharmacokinetics of a novel anticancer drug, UCN-01 (7-hydroxystaurosporine), caused by slow dissociation of UCN-01 from human alpha1-acid glycoprotein.	scientific article published in May 2000

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

Physiological modeling of altered pharmacokinetics of a novel anticancer drug, UCN-01 (7-hydroxystaurosporine), caused by slow dissociation of UCN-01 from human alpha1-acid glycoprotein. (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

pharmacokinetics

1 reference

based on heuristic

inferred from title

author name string

E Fuse

1

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

A Hashimoto

2

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

N Sato

3

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

H Tanii

4

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

T Kuwabara

5

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

S Kobayashi

6

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

Y Sugiyama

7

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

publication date

1 May 2000

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

Pharmaceutical Research

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Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

17

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Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

5

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

553-564

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered pharmacokinetics of a novel anticancer drug, UCN-01, caused by specific high affinity binding to alpha1-acid glycoprotein in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug binding to human alpha-1-acid glycoprotein in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor, UCN-01

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A nonlinear least squares program based on differential equations, MULTI (RUNGE), for microcomputers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological parameters in laboratory animals and humans

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https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a highly sensitive high-performance liquid chromatographic method for measuring an anticancer drug, UCN-01, in human plasma or urine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of the convenient and direct numerical analytical method of the pharmacokinetics of phenytoin by an ordinary and/or the Bayesian weighted least-squares method using the program MULTI2(BAYES)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of the maximal tolerated dose (MTD) and therapeutic effect of anticancer drugs in humans: integration of pharmacokinetics with pharmacodynamics and toxicodynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma and Tissue Binding Considerations in Drug Disposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10888307

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1007512832006

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 April 2018

http://europepmc.org/abstract/MED/10888307

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