Genome-scale metabolic model of Pichia pastoris with native and humanized glycosylation of recombinant proteins (Q51680535)

9 April 2018

title

Genome-scale metabolic model of Pichia pastoris with native and humanized glycosylation of recombinant proteins (English)

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9 April 2018

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Pichia pastoris

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based on heuristic

inferred from title

author

Seyed Abbas Shojaosadati

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Jens Nielsen

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Eduard J Kerkhoven

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Zahra Azimzadeh Irani

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9 April 2018

publication date

19 October 2015

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9 April 2018

Biotechnology and Bioengineering

published in

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volume

113

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issue

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page(s)

961-969

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The RAVEN toolbox and its use for generating a genome-scale metabolic model for Penicillium chrysogenum

cites work

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A macrokinetic model-based comparative meta-analysis of recombinant protein production by Pichia pastoris under AOX1 promoter.

21 January 2018

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Albumin Redhill (-1 Arg, 320 Ala----Thr): a glycoprotein variant of human serum albumin whose precursor has an aberrant signal peptidase cleavage site

21 January 2018

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Genetic engineering of Pichia pastoris to humanize N-glycosylation of proteins

21 January 2018

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Macromolecular and elemental composition analysis and extracellular metabolite balances of Pichia pastoris growing at different oxygen levels.

21 January 2018

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Genome-scale metabolic reconstructions of Pichia stipitis and Pichia pastoris and in silico evaluation of their potentials

21 January 2018

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Heterologous protein expression in the methylotrophic yeast Pichia pastoris

21 January 2018

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Comprehensive analysis of protein N-glycosylation sites by combining chemical deglycosylation with LC-MS.

21 January 2018

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Glycan engineering and production of 'humanized' glycoprotein in yeast cells

21 January 2018

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In silico identification of gene amplification targets for improvement of lycopene production

21 January 2018

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Genome-scale metabolic reconstruction and in silico analysis of methylotrophic yeast Pichia pastoris for strain improvement

21 January 2018

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Recombinant protein expression in Pichia pastoris

21 January 2018

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The secretory pathway: exploring yeast diversity

21 January 2018

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The effect of temperature on the proteome of recombinant Pichia pastoris.

21 January 2018

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Genome-scale modeling of the protein secretory machinery in yeast

21 January 2018

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Humanization of yeast to produce complex terminally sialylated glycoproteins

21 January 2018

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Glycosylation engineering in yeast: the advent of fully humanized yeast

21 January 2018

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Intracellular functions of N-linked glycans

21 January 2018

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Effects of gene dosage, promoters, and substrates on unfolded protein stress of recombinant Pichia pastoris

21 January 2018

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Metabolic flux analysis of recombinant Pichia pastoris growing on different glycerol/methanol mixtures by iterative fitting of NMR-derived (13)C-labelling data from proteinogenic amino acids

21 January 2018

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Mixed feeds of glycerol and methanol can improve the performance of Pichia pastoris cultures: A quantitative study based on concentration gradients in transient continuous cultures

21 January 2018

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A quantitative analysis of the benefits of mixed feeds of sorbitol and methanol for the production of recombinant avidin with Pichia pastoris

21 January 2018

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Optimisation of culture conditions with respect to biotin requirement for the production of recombinant avidin in Pichia pastoris

21 January 2018

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The highly conserved Stt3 protein is a subunit of the yeast oligosaccharyltransferase and forms a subcomplex with Ost3p and Ost4p

21 January 2018

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Applications of genome-scale metabolic network model in metabolic engineering

21 January 2018

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The development of recombinant human serum albumin

21 January 2018

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Pichia pastoris secretes recombinant proteins less efficiently than Chinese hamster ovary cells but allows higher space-time yields for less complex proteins

21 January 2018

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Directed gene copy number amplification in Pichia pastoris by vector integration into the ribosomal DNA locus.

21 January 2018

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Model based engineering of Pichia pastoris central metabolism enhances recombinant protein production

21 January 2018

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Quo vadis? The challenges of recombinant protein folding and secretion in Pichia pastoris

21 January 2018

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The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferases

21 January 2018

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Differential gene expression in recombinant Pichia pastoris analysed by heterologous DNA microarray hybridisation

21 January 2018

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Genome-scale metabolic model of methylotrophic yeast Pichia pastoris and its use for in silico analysis of heterologous protein production.

21 January 2018

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Amino acid biosynthesis and metabolic flux profiling of Pichia pastoris

21 January 2018

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Metabolic flux profiling of Pichia pastoris grown on glycerol/methanol mixtures in chemostat cultures at low and high dilution rates

21 January 2018

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Optimization of cell density and dilution rate in Pichia pastoris continuous fermentations for production of recombinant proteins

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.25863

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9 April 2018

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9 April 2018