C-X-C motif chemokine ligand 13 (Q5014877)

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mammalian protein found in Homo sapiens

• small-inducible cytokine B13
• Angie
• chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
• B-lymphocyte chemoattractant
• C-X-C motif chemokine 13
• CXCL13
• small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)
• B-cell chemoattractant
• CXC chemokine BLC
• b lymphocyte chemoattractant
• B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)
• b cell-attracting chemokine 1
• BCA-1
• B-cell-attracting chemokine 1

edit

Language	Label	Description	Also known as
English	C-X-C motif chemokine ligand 13	mammalian protein found in Homo sapiens	small-inducible cytokine B13 Angie chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) B-lymphocyte chemoattractant C-X-C motif chemokine 13 CXCL13 small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant) B-cell chemoattractant CXC chemokine BLC b lymphocyte chemoattractant B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1) b cell-attracting chemokine 1 BCA-1 B-cell-attracting chemokine 1

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O43927

part of

Chemokine interleukin-8-like superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O43927

CXC chemokine

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O43927

Chemokine interleukin-8-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CXC Chemokine domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CXC chemokine, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O43927

encoded by

CXCL13

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O43927

molecular function

receptor ligand activity

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

CCR10 chemokine receptor binding

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

cytokine activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O43927

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IEA

heparin binding

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endothelial cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

CXCR3 chemokine receptor binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IPI

chemokine activity

determination method or standard

IDA

IEA

2 references

retrieved

16 July 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43927&geneProductId=UniProtKB:O43927

determination method or standard

IEA

retrieved

16 July 2018

stated in

Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43927&geneProductId=UniProtKB:O43927

determination method or standard

IDA

protein heterodimerization activity

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endothelial cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

fibroblast growth factor binding

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endothelial cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

CXCR5 chemokine receptor binding

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

chemokine activity

determination method or standard

IBA

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IEA

retrieved

8 April 2019

stated in

Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IBA

cell component

extracellular region

determination method or standard

IDA

IEA

TAS

5 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O43927

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IEA

retrieved

8 April 2019

stated in

Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

retrieved

8 April 2019

stated in

Borrelia garinii induces CXCL13 production in human monocytes through Toll-like receptor 2

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

extracellular space

determination method or standard

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O43927

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IBA

biological process

chemokine-mediated signaling pathway

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IBA

positive regulation of cytosolic calcium ion concentration

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

cell-cell signaling

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

germinal center formation

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

NAS

regulation of angiogenesis

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endothelial cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

NAS

chemotaxis

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O43927

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IEA

endothelial cell chemotaxis to fibroblast growth factor

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endothelial cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

regulation of humoral immune response

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Modulation of lymphocyte migration to the murine spleen after marginal zone macrophage phagocytosis of blood-borne particulate material

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

NAS

cell surface receptor signaling pathway

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

response to lipopolysaccharide

determination method or standard

IBA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43927&geneProductId=UniProtKB:O43927

determination method or standard

IBA

regulation of cell population proliferation

determination method or standard

IBA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43927&geneProductId=UniProtKB:O43927

determination method or standard

IBA

defense response to bacterium

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Borrelia garinii induces CXCL13 production in human monocytes through Toll-like receptor 2

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

negative regulation of endothelial cell chemotaxis to fibroblast growth factor

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endothelial cells

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

positive regulation of T cell chemotaxis

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

immune response

determination method or standard

IC

IBA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IEA

retrieved

8 April 2019

stated in

Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IC

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IBA

inflammatory response

determination method or standard

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O43927

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IBA

chronic inflammatory response

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

NAS

defense response

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IEA

antimicrobial humoral immune response mediated by antimicrobial peptide

determination method or standard

IDA

1 reference

retrieved

1 January 2018

stated in

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.

GOA

curator

UniProt

UniProt protein ID

O43927

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43927&geneProductId=UniProtKB:O43927

determination method or standard

IDA

regulation of signaling receptor activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IEA

G protein-coupled receptor signaling pathway

determination method or standard

IBA

TAS

2 references

retrieved

16 July 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43927&geneProductId=UniProtKB:O43927

determination method or standard

TAS

retrieved

16 July 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43927&geneProductId=UniProtKB:O43927

determination method or standard

IBA

lymphocyte chemotaxis across high endothelial venule

determination method or standard

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

ISS

positive regulation of integrin activation

determination method or standard

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

ISS

positive regulation of cell-cell adhesion mediated by integrin

determination method or standard

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

ISS

B cell chemotaxis

determination method or standard

IDA

1 reference

retrieved

16 July 2018

stated in

B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43927&geneProductId=UniProtKB:O43927

determination method or standard

IDA

activation of GTPase activity

determination method or standard

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

ISS

G protein-coupled receptor signaling pathway

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

TAS

neutrophil chemotaxis

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IBA

leukocyte chemotaxis

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IBA

B cell chemotaxis

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IBA

antimicrobial humoral immune response mediated by antimicrobial peptide

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IBA

cellular response to lipopolysaccharide

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43927

determination method or standard

IBA

exact match

http://purl.uniprot.org/uniprot/O43927

1 reference

stated in

Identifiers.org

has part(s)

CXC chemokine, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O43927

Chemokine interleukin-8-like domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O43927

CXC Chemokine domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O43927

Identifiers

MeSH descriptor ID

D054382

subject named as

Chemokine CXCL13

0 references

MeSH tree code

D12.644.276.374.200.120.650

0 references

D12.776.467.374.200.120.650

0 references

D23.125.300.120.650

0 references

D23.469.200.120.650

0 references

D23.529.374.200.120.650

0 references

RefSeq protein ID

NP_006410

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

10563

NP_001358487

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

10563

UniProt protein ID

O43927

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O43927

Ensembl protein ID

ENSP00000286758

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000286758

Freebase ID

/m/027mxfd

0 references

Microsoft Academic ID

75877943

0 references

OpenAlex ID

C75877943

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

4ZAI

1 reference

stated in

UniProt

UniProt protein ID

O43927

retrieved

4 August 2016

language of work or name

English

5CBA

1 reference

stated in

UniProt

UniProt protein ID

O43927

retrieved

4 August 2016

language of work or name

English

5CBE

1 reference

stated in

UniProt

UniProt protein ID

O43927

retrieved

4 August 2016

language of work or name

English

UMLS CUI

C1955903

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

Wikipedia(8 entries)

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• arwiki CXCL13
• bswiki CXCL13
• dewiki CXCL13
• enwiki CXCL13
• frwiki CXCL13
• shwiki CXCL13
• srwiki CXCL13
• ukwiki CXCL13

Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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