Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling (Q58800770)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

title

Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

0 references

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

Katherine R Balka

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

Yamel Cardona Gloria

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

Vikram R Rao

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

Eicke Latz

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

language of work or name

English

0 references

publication date

3 August 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

16 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

volume

293

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

page(s)

15195-15207

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub.

16 April 2020

cites work

1 reference

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Crystal structure of human IRAK1.

30 November 2018

1 reference

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Examining Myddosome Formation by Luminescence-Based Mammalian Interactome Mapping (LUMIER).

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Generation of Innate Immune Reporter Cells Using Retroviral Transduction.

30 November 2018

1 reference

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IRAK4 kinase activity controls Toll-like receptor-induced inflammation through the transcription factor IRF5 in primary human monocytes.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Activation of the Innate Immune Receptors: Guardians of the Micro Galaxy : Activation and Functions of the Innate Immune Receptors.

30 November 2018

1 reference

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The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists.

30 November 2018

1 reference

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Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based D

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Toll-like receptors: Activation, signalling and transcriptional modulation.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assembly

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Oncogenically active MYD88 mutations in human lymphoma

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Origin and physiological roles of inflammation

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

IRAK-4-dependent degradation of IRAK-1 is a negative feedback signal for TLR-mediated NF-kappaB activation

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Structure and function of Toll receptors and their ligands

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Cutting Edge: IL-1 receptor-associated kinase 4 structures reveal novel features and multiple conformations

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Pyogenic bacterial infections in humans with IRAK-4 deficiency

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Distinct molecular mechanism for initiating TRAF6 signalling

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Regulation of IL-1 receptor-associated kinases by lipopolysaccharide

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6166714

The Interleukin-1 Receptor-associated Kinase Is Degraded by Proteasomes following Its Phosphorylation

30 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30076215

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Down-regulation of IRAK-4 is a component of LPS- and CpG DNA-induced tolerance in macrophages

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30076215

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Immortalization of Murine Bone Marrow-Derived Macrophages

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30076215

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.RA118.003314

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

PubMed publication ID

30076215

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30076215%20AND%20SRC:MED&resulttype=core&format=json