Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance (Q58115582)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30367042%20AND%20SRC:MED&resulttype=core&format=json

30 April 2020

title

Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance (English)

1 reference

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30 April 2020

0 references

1 reference

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30 April 2020

1 reference

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30 April 2020

1 reference

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30 April 2020

Gaofeng Xiong

1 reference

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30 April 2020

Jie Chen

1 reference

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30 April 2020

Tianyan Gao

1 reference

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30 April 2020

Timothy L Scott

1 reference

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30 April 2020

Luis M Samayoa

1 reference

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30 April 2020

Andrew N Lane

1 reference

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30 April 2020

language of work or name

English

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publication date

26 October 2018

1 reference

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30 April 2020

published in

Nature Communications

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30 April 2020

volume

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30 April 2020

issue

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30 April 2020

page(s)

4456

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JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance

30 April 2020

cites work

1 reference

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Applications of NMR spectroscopy to systems biochemistry

30 November 2018

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Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids

30 November 2018

1 reference

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Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

30 November 2018

1 reference

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Stem cells and the impact of ROS signaling

30 November 2018

1 reference

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HIF-1 signaling in drug resistance to chemotherapy

30 November 2018

1 reference

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XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

30 November 2018

1 reference

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Metabolic requirements for the maintenance of self-renewing stem cells

30 November 2018

1 reference

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Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition

30 November 2018

1 reference

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HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

30 November 2018

1 reference

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Patient-derived tumor xenografts: transforming clinical samples into mouse models

30 November 2018

1 reference

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Collagen prolyl hydroxylases are essential for breast cancer metastasis

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts

30 November 2018

1 reference

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Mechanisms of chemoresistance in cancer stem cells

30 November 2018

1 reference

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Comprehensive molecular portraits of human breast tumours

30 November 2018

1 reference

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Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production.

30 November 2018

1 reference

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Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

30 November 2018

1 reference

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SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors.

30 November 2018

1 reference

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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

30 November 2018

1 reference

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A gene signature for predicting outcome in patients with basal-like breast cancer

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

The extracellular matrix: a dynamic niche in cancer progression

30 November 2018

1 reference

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Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer

30 November 2018

1 reference

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HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

30 November 2018

1 reference

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30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

30 November 2018

1 reference

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An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

30 November 2018

1 reference

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Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

30 November 2018

1 reference

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Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

30 November 2018

1 reference

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An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.

30 November 2018

1 reference

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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

30 November 2018

1 reference

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The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies

30 November 2018

1 reference

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Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature

30 November 2018

1 reference

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Hypoxia, HIF1 and glucose metabolism in the solid tumour

30 November 2018

1 reference

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

30 November 2018

1 reference

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Triple-negative/basal-like breast cancer: review

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Basal-like breast cancer: a critical review

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

The epithelial-mesenchymal transition generates cells with properties of stem cells

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Collagen density promotes mammary tumor initiation and progression

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Isotopomer-based metabolomic analysis by NMR and mass spectrometry

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Hypoxia-Inducible Factor-1 Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Prospective identification of tumorigenic breast cancer cells

30 November 2018

1 reference

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Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

A conserved family of prolyl-4-hydroxylases that modify HIF

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6203834

Gly-X-Y tripeptide frequencies in collagen: a context for host-guest triple-helical peptides

30 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41467-018-06893-9

inferred from DOI database lookup

7 January 2021

based on heuristic

The novel type II prolyl 4-hydroxylase is the main enzyme form in chondrocytes and capillary endothelial cells, whereas the type I enzyme predominates in most cells

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41467-018-06893-9

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/S41467-018-06893-9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30367042%20AND%20SRC:MED&resulttype=core&format=json

30 April 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30367042%20AND%20SRC:MED&resulttype=core&format=json

30 April 2020

PubMed publication ID

30367042

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30367042%20AND%20SRC:MED&resulttype=core&format=json