Diabetes induces selective alterations in the expression of protein kinase C isoforms in hepatocytes (Q57910668)

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29 October 2019

title

Diabetes induces selective alterations in the expression of protein kinase C isoforms in hepatocytes (English)

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29 October 2019

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Peter Joseph Jacques Parker

series ordinal

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29 October 2019

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29 October 2019

E Y Tang

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29 October 2019

J Beattie

series ordinal

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29 October 2019

language of work or name

English

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publication date

1 July 1993

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29 October 2019

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29 October 2019

volume

326

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29 October 2019

issue

1-3

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29 October 2019

page(s)

117-123

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The molecular heterogeneity of protein kinase C and its implications for cellular regulation

29 October 2019

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Gi-2 is at the centre of an active phosphorylation/dephosphorylation cycle in hepatocytes: the fine-tuning of stimulatory and inhibitory inputs into adenylate cyclase in normal and diabetic states

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The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism

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Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon

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Activation of membrane protein kinase C by glucagon and Ca2+-mobilizing hormones in cultured rat hepatocytes. Role of phosphatidylinositol and phosphatidylcholine hydrolysis

21 January 2018

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Glucagon, vasopressin and angiotensin all elicit a rapid, transient increase in hepatocyte protein kinase C activity

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Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

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Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes

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Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation

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21 January 2018

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21 January 2018

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29 October 2019

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