Dkk-1-Mediated Inhibition of Wnt Signaling in Bone Ameliorates Osteoarthritis in Mice (Q57714132)

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11 March 2020

title

Dkk-1-mediated inhibition of Wnt signaling in bone ameliorates osteoarthritis in mice (English)

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11 March 2020

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Thomas Funck-brentano

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11 March 2020

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11 March 2020

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11 March 2020

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11 March 2020

Wafa Bouaziz

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11 March 2020

Caroline Marty

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11 March 2020

publication date

1 November 2014

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11 March 2020

published in

Arthritis & Rheumatology

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volume

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issue

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page(s)

3028-3039

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Osteoarthritis: epidemiology

11 March 2020

cites work

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Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

21 January 2018

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Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism

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Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study

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Pharmacologic therapy for osteoarthritis—the era of disease modification

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To Wnt or not to Wnt: the bone and joint health dilemma

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Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton

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Regulation of bone mass by Wnt signaling

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Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

21 January 2018

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Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction

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Wnt regulation of chondrocyte differentiation.

21 January 2018

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Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development

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Wnt/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration

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Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women

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1 reference

Gremlin 1, Frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis

21 January 2018

1 reference

Dkk-1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints.

21 January 2018

1 reference

Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees.

21 January 2018

1 reference

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

21 January 2018

1 reference

Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury

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The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse.

21 January 2018

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1 reference

N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation

21 January 2018

1 reference

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21 January 2018

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21 January 2018

The amazing osteocyte

1 reference

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

21 January 2018

1 reference

Synovial perlecan is required for osteophyte formation in knee osteoarthritis

21 January 2018

1 reference

Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study).

21 January 2018

1 reference

Identification of a stem cell niche in the zone of Ranvier within the knee joint.

21 January 2018

1 reference

Molecular differentiation between osteophytic and articular cartilage--clues for a transient and permanent chondrocyte phenotype

21 January 2018

1 reference

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1.

21 January 2018

1 reference

WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways

21 January 2018

1 reference

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors.

21 January 2018

1 reference

Bone parameters across different types of hip osteoarthritis and their relationship to osteoporotic fracture risk

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1 reference

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21 January 2018

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Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/ART.38799

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11 March 2020

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