Stereoselective Block of hERG Channel by (S)-Methadone and QT Interval Prolongation in CYP2B6 Slow Metabolizers (Q57550254)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

title

Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

Jean-Sébastien Rougier

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

S Crettol

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

J Schläpfer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

L Sintra Grilo

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

J-J Déglon

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

J Besson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

M Croquette-Krokar

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

P-A Carrupt

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

language of work or name

English

0 references

publication date

28 February 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

Clinical Pharmacology & Therapeutics

26 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

page(s)

719-728

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

Torsade de pointes associated with very-high-dose methadone

26 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

High dose methadone and ventricular arrhythmias: a report of three cases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Torsades de Pointes Due to Methadone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Qt prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Torsade de pointes due to methadone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

QT interval prolongation in patients on methadone with concomitant drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

QT prolongation and torsades de pointes among methadone users: reports to the FDA spontaneous reporting system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

QTc interval prolongation associated with intravenous methadone.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

ABCB1 and cytochrome P450 genotypes and phenotypes: Influence on methadone plasma levels and response to treatment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Intragenic Suppression of Trafficking-Defective KCNH2 Channels Associated with Long QT Syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Urinary metabolites of DL-methadone in maintenance subjects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Pharmacokinetic drug interactions between opioid agonist therapy and antiretroviral medications: implications and management for clinical practice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

The d- and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Ketobemidone, methadone and pethidine are non-competitive N-methyl-D-aspartate (NMDA) antagonists in the rat cortex and spinal cord

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Local anesthetic interaction with human ether-a-go-go-related gene (HERG) channels: role of aromatic amino acids Y652 and F656.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: stereoselective bupivacaine block

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Do single enantiomers have something special to offer?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Effect of trazodone on hERG channel current and QT-interval.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-time PCR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CLPT.6100120

7 January 2021

Identifiers

DOI

10.1038/SJ.CLPT.6100120

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17329992%20AND%20SRC:MED&resulttype=core&format=json